This unit of study examines in detail the anatomy of the gastrointestinal tract, from the oral cavity to anal canal, and includes the liver, gallbladder and pancreas. This is complemented by description of the specialised cells in the gastrointestinal tract, followed by discussion of the transport mechanisms employed to absorb nutrients, and consideration of control systems used to regulate activity of the digestive process. The role of intestinal microflora in the gastrointestinal tract, contributing to both beneficial digestion and absorption of nutrients, as well as to pathogenic disruption, is also discussed. The fate of the macronutrients (carbohydrate, fat and protein) is then considered in terms of their uptake, disposal and reassembly into storage fuels and cellular structures. The biochemical pathways involved in the extraction of energy from the macronutrient fuels are then covered. Examples of these metabolic processes are provided by considering fuel selection during starvation and in diabetes. Finally, pharmacokinetics and pharmacogenomics are explored, with discussion of the metabolism and absorption of drugs including detoxification and excretion of xenobiotic compounds. Practical classes give students extensive experience with inspection of the gastrointestinal system at both the cellular and gross anatomical levels, and in theassay of biochemicals such as glucose. These sessions are designed to nurture observation, data analysis, record keeping and report writing skills.
Two lectures and one tutorial or one practical session per week
One 2-hour theory exam (60%), five in-semester assignments/assessments (40%)
Human Physiology: An integrated approach Silverthorn D Pearson/Benjamin Cummings, 6th Edition, 2013 Prescott's Microbiology Willey JM, Sherwood LM and Woolverton CJ McGraw-Hill, 10th Edition, 2016 The Anatomy Coloring Book Kapit W and Elson LM Benjamin Cummings, 4th Edition, 2014 Histology: A text and Atlas Ross MH and Pawlina W Lippincott, Williams and Wilkins, 7th Edition, 2015 Medical Pharmacology at a Glance Neal MJ Blackwell Science, 7th Edition, 2012 Textbook of Biochemistry with Clinical Correlations Devlin TM John Wiley and Sons Inc., 7th Edition, 2011
30 credit points from [12cp from CHEM1XXX and 12cp from MATH1XXX and 12cp from (BIOL1XXX, MBLG1XXX)]Prohibitions
ANAT2008 or ANAT2010 or ANAT2011 or ANAT2910 or BCHM2072 or BCHM2972 or BIOL2006 or BIOL2016 or BIOL2906 or BIOL2916 or BMED2807 or BMED2904 or IMMU2101 or MICR2021 or MICR2022 or MICR2921 or MICR2922 or NUTR2911 or NUTR2912 or PCOL2011