The special skills of translational research will be highlighted in this unit. Candidates will understand the potential uses for biomarkers in clinical practice; how to use study designs relevant for biomarker evaluation and how to incorporate biomarker studies and biospecimen (tissue and blood) collection into clinical research projects. Candidates will learn the difference between prognostic, predictive and surrogate biomarkers and biostatistical considerations in their analysis. The complexities of international regulations regarding patient consent, biospecimen collection and shipment will be highlighted.
discussion groups and problem based learning
2x quizzes (2x10%), 2x assessments (2x40%)
Recommended reading: Altman DG, McShane LM, Sauerbrei W, Taube SE (2012)Reporting Recommendations for Tumor Marker Prognostic Studies (REMARK): Explanation and Elaboration.PLoS Med (5): e1001216. doi:10.1371/journal.pmed.1001216