This unit will explore the early phases of the drug discovery process from identification of a biological target molecule (enzyme or receptor) to identification of lead molecules and how chemical synthesis and biological screening is applied to develop lead molecules into drugs with desired molecular properties. Topics include drug discovery, protein structure and function, protein structure determination, drug synthesis, spectroscopic analysis, functional groups, molecular properties, molecular modelling, structure based drug design, drug screening. Students will also gain experience in a variety of experimental techniques related to drug design. In addition, students will develop skills including critical thinking, the use of information technology and report writing.
Final exam (60%); Laboratory report and presentation (20%); Molecular Modeling Reports (5% + 15%)
Patrick GL. An Introduction to Medicinal Chemistry (5th ed). Oxford University Press, 2013
6 credit points of Biochemistry, 12 credit points of Chemistry, 12 credit points of Pharmacology, 12 credit points of Physiology. Students who have not completed up to 12 credit points of pre-requisite subjects are strongly advised to take the corresponding Bridging Course offered in February or July and as a distance course at other times of the year.