In this unit of study students learn to evaluate the physicochemical principles, design, formulation, and manufacture of pharmaceutical dose forms. The formulation of liquid dose forms including parenteral, nasal, ophthalmic and aural products is discussed. Related topics such as diffusion and dissolution of drugs, drug solubilisation, surface and interfacial tension, surface active materials, micelle formation, pharmaceutical complexes and drug-packaging interactions are covered. Other topics covered in this unit include biomaterials; solid dose forms and particle science that comprise tableting and capsule technology; rheology, freezing point depression, osmosis, dispersion dose forms including suspensions, colloidal dispersions, and emulsions; topical dose forms and semisolids; inhalation pharmaceutical aerosols; biopharmaceuticals including protein and peptide drugs, vaccines and their formulations; rectal products; novel drug delivery technologies. Aspects pertaining to the stability of dose forms are also presented in this unit.
3 x lecs/week, 1 x tutorial/week
Final exam (55%), minor exam (10%), laboratory practicals (35%)
Aulton M.E. Pharmaceutics: The Science of Dosage Form Design (7th edn) Churchill Livingston and A.T. Florence and D Attwood Physicochemical Principles of Pharmacy, Pharmaceutical Press 6th Edition, 2015.
6 credit points of Biochemistry, 12 credit points of Chemistry, 12 credit points of Pharmacology, 12 credit points of Physiology. Students who have not completed up to 12 credit points of pre-requisite subjects are strongly advised to take the corresponding Bridging Course offered in February or July and as a distance course at other times of the year.