Over 15,000 Australians have or will develop end-stage organ failure this year, and this number is expected to grow exponentially with the rise in underlying conditions such as diabetes and hepatitis C. Organ transplantation is thus becoming increasingly important as a therapeutic modality. This unit of study will introduce students to the fundamental principles of transplantation immunobiology, which are essential to the understanding of clinical solid organ transplantation. This unit is a prerequisite or co-requisite for students wishing to undertake SURG5022, Principles and Practice of Transplantation, and for students completing a transplantation project for their dissertation. The unit contains an introductory module and 5 learning modules, which students work through at their own pace. These modules are: 2. Overview of the Immune System, 3. MHC Biology, Antigen Presentation and Allorecognition, 4. Effector mechanisms in Transplant Rejection, 5. Brain Death, Ischaemia-Reperfusion Injury and Innate Immune Responses in Transplantation, and 6. Transplantation Tolerance. Each module contains online lectures and links to recommended reading, followed by a series of short-answer questions.
The unit is delivered online and will require approximately 10 hours study per week.
Formative multiple choice question assessment of pre-existing knowledge in Immunobiology allows students to identify strengths and weaknesses before starting the leaning modules. Short-answer questions cover the knowledge acquired in each module. Students may access reference materials and other resources whilst completing the questions. Each set of questions must be completed and submitted by the due date (listed on the website in the document 'Schedule and Important dates for SURG_5021'), and before students proceed to the next module. Answers to each module contribute 12% to the final score for the Unit (total 60% for the 5 modules), and a multiple choice quiz to be completed in the final week of the UOS contributes 40% to the final score.
Abbas, Lichtman and Pillai, Cellular and Molecular Immunology, 7th edition, Saunders; Current transplantation literature - linked to online teaching materials. These are listed in the 'Recommended Reading' document for each module.