This unit of study will explore the biochemical processes involved in the operation of cells and how they are integrated in tissues and in the whole human body in normal and diseased states. These concepts will be illustrated by considering whole-body aspects of energy utilisation, fat and glycogen storage and their regulation under normal conditions compared to obesity and diabetes. Key concepts that will be discussed include energy balance, regulation of metabolic rate, control of food intake, tissue interactions in fuel selection, the role of adipose tissue and transport of fuel molecules from storage organs and into cells. Particular emphasis will be placed on how the modern concepts of metabolomics, coupled with molecular biology methods and studies of the structure and function of enzymes, have led to our current understanding of how metabolic processes are normally integrated and how they become deranged in disease states. The practical component is designed to complement the lecture course and will provide students with experience in a wide range of techniques used in modern medical and metabolic biochemistry.
Two 1-hour lectures per week; two 3-hours practicals per fortnight
One 2.5-hour exam (theory and theory of prac 65%), in-semester (practical work and assignments 35%)
BMedSc degree students: You must have successfully completed BMED2401 and an additional 12cp from BMED240X before enrolling in this unit.
[12cp from (BCHM2X71 or BCHM2X72 or BCMB2X01 or BCMB2X02 or MBLG2X71 or MEDS2003)] OR [BMED2401 and BMED2405 and 6cp from (BCHM2X71 or BCMB2X02 or MBLG2X71)]Prohibitions