This unit of study is designed to introduce students with a basic understanding of pharmacology to the discipline of toxicology. The study of toxicology is central to the assessment of drug safety in drug development and in the explanation of toxicology associated with registered drugs (adverse drug reactions) and drug-drug interactions. These issues as well as the pharmacogenetic basis of adverse reactions will be considered. Environmental toxicology, particularly toxic reactions to environmental agents such as asbestos and pesticides, and target organ toxicology (lung, liver, CNS) are also covered. The diverse world of plants and animal toxins will also be explored. As a final consequence of exposure to many toxicants, the biology and causes of cancer are discussed. As part of the unit students are introduced to basic ideas about the collection and analysis of data from human and animal populations, both in the structured situation of clinical trials, forensic problems and in analysis of epidemiological data.
Two 1 hour lectures per week and one 3 hour tutorial/practical every 2 weeks and two practical sessions each 3 hours in length.
One 2 hour exam, tutorial presentations, assignments (100%)
Klaasen, Curtis D. Casarett and Doull's Essentials of Toxicology 2 ed. McGraw Hill. 2010, or, by the same authors: Toxicology: The Basic Science of Poisons. 7 ed. McGraw Hill. 2008.
(PCOL2011 or PCOL2021 or MEDS2002) or (BMED2401 and BMED2405)Prohibitions