A single human cell contains billions of protein molecules that are constantly in motion. Why so many? What are they doing? And, how are they doing it? In simple terms, proteins define the function of and drive almost every process within cells. In this unit of study you will learn about the biochemistry of proteins in their natural environment - within cells - with a focus on eukaryotes including plant and other cell types. You will discover the dynamic interplay within and between proteins and other cellular components and how the physical properties of proteins dictate function. You will discover how proteins are compartmentalized, modified, folded, transported in and between cells, the mechanisms by which proteins regulate biological activities, interact and transport molecules across membranes, and how mutations in proteins can lead to pathological consequences. Our practicals, other guided and online learning sessions will introduce you to a wide range of currently utilised techniques for protein biochemistry ranging from protein visualization, quantification, purification and enzymatic activity, to in silico studies and cellular targeting experiments. By the end of this unit you will be equipped with foundational skills and knowledge to support your studies in the cellular and molecular biosciences.
Two 1-hour lectures per week; one 4-hour practical/tutorial session per week
Assignments, skills-based assessment, quiz, final exam
Lehninger Principles of Biochemistry 7th edition (2016) David L. Nelson Michael M. Cox Macmillan (ISBN-10: 1-4641-2611-9; ISBN-13: 978-1-4641-2611-6)
6cp of (BIOL1XX7 or MBLG1XXX) and 6cp of (CHEM1XX1 or CHEM1903)Prohibitions
BCHM2071 or BCHM2971 or BCMB2902