A single human cell contains billions of protein molecules that are constantly in motion. Why so many? What are they doing? And, how are they doing it? In simple terms, proteins define the function of and drive almost every process within cells. In this unit of study you will learn about the biochemistry of proteins in their natural environment - within cells - with a focus on eukaryotes including plant and other cell types. You will discover the dynamic interplay within and between proteins and other cellular components and how the physical properties of proteins dictate function. You will discover how proteins are compartmentalized, modified, folded, transported in and between cells, the mechanisms by which proteins regulate biological activities, interact and transport molecules across membranes, and how mutations in proteins can lead to pathological consequences. There will be a research-focused approach to the advanced practical component, including real and virtual extensions to key experiments. This approach will continue in the lecture series with several unique advanced lectures covering current research topics. You will further investigate a selected area of interest from these topics using original source material and present your findings through an oral presentation in dedicated advanced tutorials.
Two 1-hour lectures per week; one 4-hour practical/tutorial session per week
Assignment, skills-based assessment, quiz, exam
Lehninger Principles of Biochemistry 7th edition (2016) David L. Nelson Michael M. Cox Macmillan (ISBN-10: 1-4641-2611-9; ISBN-13: 978-1-4641-2611-6)
A mark of at least 70 from (BIOL1XX7 or MBLG1XX1) and (CHEM1XX1 or CHEM1903)Prohibitions
BCHM2071 or BCHM2971 or BCMB2002