student profile: Ms Jasleen Kaur Daljit Singh


Map

Thesis work

Thesis title: Targeted delivery of siRNAs using DNA nanorobots

Supervisors: Shelley WICKHAM , Ali ABBAS

Thesis abstract:

The aim of my project is to design and develop DNA origami barrels (nanorobot) for targeted delivery of small-interfering RNA (siRNAs) to cancer cells. DNA is a programable material that can be self-assembled from the bottom-up to form biocompatible nanostructures such as DNA barrels. The interior of each barrel is designed such that it can be loaded with multiple siRNAs while the outer surface of the barrel is functionalized with DNA aptamers that bind to prostate cell surface marker (PSMA). The barrels will only be internalized by cells expressing PSMA and the siRNAs will be released in the cells, resulting in gene silencing.

Selected grants

2018

  • Biomolecular Design Competition (BIOMOD) 2018; Daljit Singh J, Wickham S, Williamson A; NSW Department of Industry/Science and Engineering Student Competition Sponsorship Program.

Selected publications

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Journals

  • Daljit Singh, J., Luu, M., Abbas, A., Wickham, S. (2018). Switchable DNA-origami nanostructures that respond to their environment and their applications. Biophysical Reviews, 10(5), 1283-1293. [More Information]

2018

  • Daljit Singh, J., Luu, M., Abbas, A., Wickham, S. (2018). Switchable DNA-origami nanostructures that respond to their environment and their applications. Biophysical Reviews, 10(5), 1283-1293. [More Information]

Note: This profile is for a student at the University of Sydney. Views presented here are not necessarily those of the University.