student profile: Mr Murray Hinder


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Thesis work

Thesis title: Examination of technological changes, regulatory standards, and efficacy of devices used to assist ventilation and resuscitation in newborns and infan

Supervisors: Craig JIN , Alistair MCEWAN

Thesis abstract:

Dramatic survival rate improvements have occurred in extremely preterm infants over the last 4 decades.  Medical evidence changing practise is centred on well conducted randomised clinical trials. Maternal antenatal steroids and tracheal animal derived surfactant administration are two examples of well evidenced treatments that have significantly contributed to improved outcomes for these patients.  Mortality in this group has largely been due to respiratory failure secondary to iatrogenic cascading lung injury induced by lifesaving mechanical breathing support.  Trial data has examined ways of mitigating lung injury by differing methods and technologies of breathing support from delivery to several weeks of age. There are inherent assumptions that manual and mechanical systems delivering time cycled positive pressure ventilation behave in predictable and similar ways to allow safe generalisation of trial evidence to benefit infants.�br /� This proposed research program by publication will specifically examine if there are systematic differences between brands and types of manually operated breathing support systems, the interface devices used to attach these systems to deliver effective tidal ventilation, and how ISO standards relate to these systems. These will include:�br /� 1.       The Self Inflating Bag (SIB) resuscitator.�br /�  �br /� 2.       T-piece infant resuscitators (Neopuff NP).�br /�  �br /� 3.       Laryngeal Mask Airway (LMA).�br /�  �br /� 4.        Mechanical ventilation systems.�br /�  �br /� Do the Infant breathing systems perform as expected and do they provide safe, consistent delivery of respiratory assistance within clinical guidelines?�br /� Are current ISO standards and clinical guidelines (ILCOR) for  infant breathing systems adequate to safeguard infants across such a wide operating weight range (≈ 450gms to 10kgs) and possible lung states?

Selected publications

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Journals

  • Huvanandana, J., Thamrin, C., Tracy, M., Hinder, M., Nguyen, C., McEwan, A. (2017). Advanced analyses of physiological signals in the neonatal intensive care unit. Physiological Measurement, 38(10), R253-R279. [More Information]
  • Tracy, M., Maheshwari, R., Shah, D., Hinder, M. (2017). Can Ambu self-inflating bag and Neopuff infant resuscitator provide adequate and safe manual inflations for infants up to 10 kg weight? Archives of Disease in Childhood: Fetal and Neonatal Edition, 102(4), F333-F338. [More Information]
  • Hinder, M., Jani, P., Priyadarshi, A., McEwan, A., Tracy, M. (2017). Neopuff T-piece resuscitator: Does device design affect delivered ventilation? Archives of Disease in Childhood: Fetal and Neonatal Edition, 102(3), F220-F224. [More Information]
  • Huvanandana, J., Nguyen, C., Thamrin, C., Tracy, M., Hinder, M., McEwan, A. (2017). Prediction of intraventricular haemorrhage in preterm infants using time series analysis of blood pressure and respiratory signals. Scientific Reports, 7, 1-9. [More Information]
  • Hinder, M., Perdomo, A., Tracy, M. (2016). Dangerous Pressurization and Inappropriate Alarms during Water Occlusion of the Expiratory Circuit of Commonly Used Infant Ventilators. PloS One, 11(4), 1-10. [More Information]
  • Tracy, M., Shah, D., Priyadarshi, A., Hinder, M. (2016). The effectiveness of Ambu neonatal self-inflating bag to provide consistent positive end-expiratory pressure. Archives of Disease in Childhood: Fetal and Neonatal Edition, 101(5), F439-F443. [More Information]

2017

  • Huvanandana, J., Thamrin, C., Tracy, M., Hinder, M., Nguyen, C., McEwan, A. (2017). Advanced analyses of physiological signals in the neonatal intensive care unit. Physiological Measurement, 38(10), R253-R279. [More Information]
  • Tracy, M., Maheshwari, R., Shah, D., Hinder, M. (2017). Can Ambu self-inflating bag and Neopuff infant resuscitator provide adequate and safe manual inflations for infants up to 10 kg weight? Archives of Disease in Childhood: Fetal and Neonatal Edition, 102(4), F333-F338. [More Information]
  • Hinder, M., Jani, P., Priyadarshi, A., McEwan, A., Tracy, M. (2017). Neopuff T-piece resuscitator: Does device design affect delivered ventilation? Archives of Disease in Childhood: Fetal and Neonatal Edition, 102(3), F220-F224. [More Information]
  • Huvanandana, J., Nguyen, C., Thamrin, C., Tracy, M., Hinder, M., McEwan, A. (2017). Prediction of intraventricular haemorrhage in preterm infants using time series analysis of blood pressure and respiratory signals. Scientific Reports, 7, 1-9. [More Information]

2016

  • Hinder, M., Perdomo, A., Tracy, M. (2016). Dangerous Pressurization and Inappropriate Alarms during Water Occlusion of the Expiratory Circuit of Commonly Used Infant Ventilators. PloS One, 11(4), 1-10. [More Information]
  • Tracy, M., Shah, D., Priyadarshi, A., Hinder, M. (2016). The effectiveness of Ambu neonatal self-inflating bag to provide consistent positive end-expiratory pressure. Archives of Disease in Childhood: Fetal and Neonatal Edition, 101(5), F439-F443. [More Information]

Note: This profile is for a student at the University of Sydney. Views presented here are not necessarily those of the University.