Dr Yogambha Ramaswamy

Lecturer
School of Aerospace, Mechanical and Mechatronic Engineering

J07 - Mechanical Engineering Building
The University of Sydney

Biographical details

Dr.Ramaswamy is a chemical engineer with a Master’s degree in Biotechnology from University of Queensland, and was awarded a PhD. in Biomedical Engineering from the University of Sydney in 2009. She then commenced her postdoctoral academic career as a Vice-Chancellor’s Post-Doctoral Research Fellow in the Graduate School of Biomedical Engineering at the University of New South Wales. She was then awarded the Peter Doherty Early Career Fellowship in 2013 and moved to University of Sydney in 2015. Since then, she has been involved in research, teaching and student supervision in the School of AMME.

Dr. Ramaswamy has developed a keen interest in the field of biomaterials and tissue engineering and has worked in this research area for over 10 years. She applies the principles of engineering and life sciences towards developing and characterising biomaterials such as bioceramics and biopolymers for hard and soft tissue applications. Her most significant contributions have been in developing and establishing the biological responses of bone cells (osteoblasts and osteoclasts) on calcium silicate based ceramics, rendered as a potential material for orthopedic applications. She has now extended her research interests in the emerging field of mechanobiology, where she is utilising biopolymer platforms to understand the role of physical cues in modulating the activity of stem cells and cancer cells. Understanding the fundamental mechanisms by which biological cells sense and respond to physical cues can lead to the development of novel treatments and therapies for a variety of diseases. Her overall goal is to be enthusiastic and committed to resolving some of the unanswered questions in mechanobiology and biomaterials using innovative ideas that can eventually lead to the betterment of society and improve the quality of life.

Teaching and supervision

AMME1961 – Introduction to Biomedical Engineering B
AMME5962 – Introduction to Mechanobiology

Current research students

Project title Research student
Development and Characterisation of Sr-HT-Gahnite Cervical Fusion Cage for Commercial Use Ellen NEWSOM
Developing innovative technologies to study cell microenvironments in the context of mechanobiology Christina VIRAY

International collaboration


    Domestic collaboration


      Selected grants

      2019

      • Multifunctional Chiral Plasmonic Nanoparticles For Photodynamic Therapy; Zreiqat H, Bisht B, Singh G, Ramaswamy Y; Office of Global Engagement/Research Alliances.

      2015

      • Smart hybrid material for cartilage tissue engineering; Ramaswamy Y; National Health and Medical Research Council (NHMRC)/Early Career Fellowships.

      Selected publications

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      Journals

      • No, Y., Xin, X., Ramaswamy, Y., Li, Y., Roohaniesfahani, S., Mustaffa, S., Shi, J., Jiang, X., Zreiqat, H. (2019). Novel injectable strontium-hardystonite phosphate cement for cancellous bone filling applications. Materials Science and Engineering C, 97, 103-115. [More Information]
      • Wu, C., Ramaswamy, Y., Zreiqat, H. (2010). Porous diopside (CaMgSi2O6) scaffold: A promising bioactive material for bone tissue engineering. Acta Biomaterialia, 6(6), 2237-2245. [More Information]
      • Zreiqat, H., Belluoccio, D., Smith, M., Wilson, R., Rowley, L., Jones, K., Ramaswamy, Y., Vogl, T., Roth, J., Bateman, J., Little, C. (2010). S100A8 and S100A9 in experimental osteoarthritis. Arthritis Research and Therapy, 12(1), 1-13. [More Information]
      • Zreiqat, H., Ramaswamy, Y., Wu, C., Paschalidis, A., Lu, Z., James, B., Birke, O., McDonald, M., Little, D., Dunstan, C. (2010). The incorporation of strontium and zinc into a calcium-silicon ceramic for bone tissue engineering. Biomaterials, 31(12), 3175-3184. [More Information]
      • Ramaswamy, Y., Wu, C., Zreiqat, H. (2009). Orthopedic coating materials: Considerations and applications. Expert Review of Medical Devices, 6(4), 423-430. [More Information]
      • Wu, C., Ramaswamy, Y., Liu, X., Wang, G., Zreiqat, H. (2009). Plasma-sprayed CaTiSiO5 ceramic coating on Ti-6AI-4V with excellent bonding strength, stability and cellular bioactivity. Journal of the Royal Society Interface, 6(1), 159-168. [More Information]
      • Ramaswamy, Y., Wu, C., Dunstan, C., Hewson, B., Eindorf, T., Anderson, G., Zreiqat, H. (2009). Sphene ceramics for orthopedic coating applications: An in vitro and in vivo study. Acta Biomaterialia, 5(8), 3192-3204. [More Information]
      • Wu, C., Ramaswamy, Y., Zhu, Y., Zheng, R., Appleyard, R., Howard, A., Zreiqat, H. (2009). The effect of mesoporous bioactive glass on the physiochemical, biological and drug-release properties of poly(DL-lactide-co-glycolide) films. Biomaterials, 30(12), 2199-2208. [More Information]
      • Ramaswamy, Y., Wu, C., Zhou, H., Zreiqat, H. (2008). Biological response of human bone cells to zinc-modified Ca-Si-based ceramics. Acta Biomaterialia, 4(5), 1487-1497. [More Information]
      • Wu, C., Ramaswamy, Y., Boughton, P., Zreiqat, H. (2008). Improvement of mechanical and biological properties of porous CaSiO3 scaffolds by poly(D,L-lactic acid) modification. Acta Biomaterialia, 4(2), 343-353. [More Information]
      • Wu, C., Ramaswamy, Y., Gail, D., Yang, W., Xiao, K., Zhang, L., Yin, Y., Zreiqat, H. (2008). Novel sphene coatings on Ti-6Al-4V for orthopaedic implants using sol-gel method. Acta Biomaterialia, 4, 569-576. [More Information]
      • Zhu, Y., Wu, C., Ramaswamy, Y., Kockrick, E., Simon, P., Kaskel, S., Zreiqat, H. (2008). Preparation, characterization and in vitro bioactivity of mesoporous bioactive glasses (MBGs) scaffolds for bone tissue engineering. Microporous and Mesoporous Materials, 112, 494-503.
      • Wu, C., Ramaswamy, Y., Chang, J., Woods, J., Chen, Y., Zreiqat, H. (2008). The Effect of Zn Contents on Phase Composition, Chemical Stability and Cellular Bioactivity in Zn-Ca-Si System Ceramics. Journal of Biomedical Materials Research - Part B Applied Biomaterials, 87(2), 346-353. [More Information]
      • Ramaswamy, Y., Wu, C., Van Hummel, A., Combes, V., Grau, G., Zreiqat, H. (2008). The responses of osteoblasts, osteoclasts and endothelial cells to zirconium modified calcium-silicate-based ceramic. Biomaterials, 29(33), 4392-4402. [More Information]
      • Wu, C., Ramaswamy, Y., Soeparto, A., Zreiqat, H. (2007). Incorporation of titanium into calcium silicate improved their chemical stability and biological properties. Journal of Biomedical Materials Research A, 86(2 (Online article 29 Oct 2007)), 402-410. [More Information]
      • Wu, C., Ramaswamy, Y., Kwik, D., Zreiqat, H. (2007). The effect of strontium incorporation into CaSiO3 ceramics on their physical and biological properties. Biomaterials, 28(21), 3171-3181. [More Information]

      Patents

      • Zreiqat, H., Wu, C., Ramaswamy, Y. (2015). Preparation and application of novel Baghdadite Scaffolds and coatings for skeletal tissue regen'n. Patent No. 9005647.
      • Zreiqat, H., Wu, C., Ramaswamy, Y. (2009). Preparation and application of novel Baghdadite (Ca3ZrSi2O9) Scaffolds and coatings for skeletal tissue regeneration. Patent No. WO/2009/052583. Worldwide.

      2019

      • No, Y., Xin, X., Ramaswamy, Y., Li, Y., Roohaniesfahani, S., Mustaffa, S., Shi, J., Jiang, X., Zreiqat, H. (2019). Novel injectable strontium-hardystonite phosphate cement for cancellous bone filling applications. Materials Science and Engineering C, 97, 103-115. [More Information]

      2015

      • Zreiqat, H., Wu, C., Ramaswamy, Y. (2015). Preparation and application of novel Baghdadite Scaffolds and coatings for skeletal tissue regen'n. Patent No. 9005647.

      2010

      • Wu, C., Ramaswamy, Y., Zreiqat, H. (2010). Porous diopside (CaMgSi2O6) scaffold: A promising bioactive material for bone tissue engineering. Acta Biomaterialia, 6(6), 2237-2245. [More Information]
      • Zreiqat, H., Belluoccio, D., Smith, M., Wilson, R., Rowley, L., Jones, K., Ramaswamy, Y., Vogl, T., Roth, J., Bateman, J., Little, C. (2010). S100A8 and S100A9 in experimental osteoarthritis. Arthritis Research and Therapy, 12(1), 1-13. [More Information]
      • Zreiqat, H., Ramaswamy, Y., Wu, C., Paschalidis, A., Lu, Z., James, B., Birke, O., McDonald, M., Little, D., Dunstan, C. (2010). The incorporation of strontium and zinc into a calcium-silicon ceramic for bone tissue engineering. Biomaterials, 31(12), 3175-3184. [More Information]

      2009

      • Zreiqat, H., Wu, C., Ramaswamy, Y. (2009). Preparation and application of novel Baghdadite (Ca3ZrSi2O9) Scaffolds and coatings for skeletal tissue regeneration. Patent No. WO/2009/052583. Worldwide.
      • Ramaswamy, Y., Wu, C., Zreiqat, H. (2009). Orthopedic coating materials: Considerations and applications. Expert Review of Medical Devices, 6(4), 423-430. [More Information]
      • Wu, C., Ramaswamy, Y., Liu, X., Wang, G., Zreiqat, H. (2009). Plasma-sprayed CaTiSiO5 ceramic coating on Ti-6AI-4V with excellent bonding strength, stability and cellular bioactivity. Journal of the Royal Society Interface, 6(1), 159-168. [More Information]
      • Ramaswamy, Y., Wu, C., Dunstan, C., Hewson, B., Eindorf, T., Anderson, G., Zreiqat, H. (2009). Sphene ceramics for orthopedic coating applications: An in vitro and in vivo study. Acta Biomaterialia, 5(8), 3192-3204. [More Information]
      • Wu, C., Ramaswamy, Y., Zhu, Y., Zheng, R., Appleyard, R., Howard, A., Zreiqat, H. (2009). The effect of mesoporous bioactive glass on the physiochemical, biological and drug-release properties of poly(DL-lactide-co-glycolide) films. Biomaterials, 30(12), 2199-2208. [More Information]

      2008

      • Ramaswamy, Y., Wu, C., Zhou, H., Zreiqat, H. (2008). Biological response of human bone cells to zinc-modified Ca-Si-based ceramics. Acta Biomaterialia, 4(5), 1487-1497. [More Information]
      • Wu, C., Ramaswamy, Y., Boughton, P., Zreiqat, H. (2008). Improvement of mechanical and biological properties of porous CaSiO3 scaffolds by poly(D,L-lactic acid) modification. Acta Biomaterialia, 4(2), 343-353. [More Information]
      • Wu, C., Ramaswamy, Y., Gail, D., Yang, W., Xiao, K., Zhang, L., Yin, Y., Zreiqat, H. (2008). Novel sphene coatings on Ti-6Al-4V for orthopaedic implants using sol-gel method. Acta Biomaterialia, 4, 569-576. [More Information]
      • Zhu, Y., Wu, C., Ramaswamy, Y., Kockrick, E., Simon, P., Kaskel, S., Zreiqat, H. (2008). Preparation, characterization and in vitro bioactivity of mesoporous bioactive glasses (MBGs) scaffolds for bone tissue engineering. Microporous and Mesoporous Materials, 112, 494-503.
      • Wu, C., Ramaswamy, Y., Chang, J., Woods, J., Chen, Y., Zreiqat, H. (2008). The Effect of Zn Contents on Phase Composition, Chemical Stability and Cellular Bioactivity in Zn-Ca-Si System Ceramics. Journal of Biomedical Materials Research - Part B Applied Biomaterials, 87(2), 346-353. [More Information]
      • Ramaswamy, Y., Wu, C., Van Hummel, A., Combes, V., Grau, G., Zreiqat, H. (2008). The responses of osteoblasts, osteoclasts and endothelial cells to zirconium modified calcium-silicate-based ceramic. Biomaterials, 29(33), 4392-4402. [More Information]

      2007

      • Wu, C., Ramaswamy, Y., Soeparto, A., Zreiqat, H. (2007). Incorporation of titanium into calcium silicate improved their chemical stability and biological properties. Journal of Biomedical Materials Research A, 86(2 (Online article 29 Oct 2007)), 402-410. [More Information]
      • Wu, C., Ramaswamy, Y., Kwik, D., Zreiqat, H. (2007). The effect of strontium incorporation into CaSiO3 ceramics on their physical and biological properties. Biomaterials, 28(21), 3171-3181. [More Information]

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