Biochemistry and Molecular Biology Descriptions

BIOCHEMISTRY AND MOLECULAR BIOLOGY

Biochemistry and Molecular Biology major

A major in Biochemistry and Molecular Biology requires 48 credit points from this table including:
(i) 12 credit points of 1000-level core units
(ii) 6 credit points of 2000-level core units
(iii) 6 credit points of 2000-level units according to the following rules:
(a) 6 credit points of 2000-level biochemistry units or
(b) 6 credit points of 2000-level MEDS coded units for students in the Medical Science stream
(iv) 12 credit points of 3000-level core units
(v) 6 credit points of 3000-level selective units
(vi) 6 credit points of 3000-level interdisciplinary project units

Biochemistry and Molecular Biology minor

A minor in Biochemistry and Molecular Biology requires 36 credit points from this table including:
(i) 12 credit points of 1000-level core units
(ii) 6 credit points of 2000-level core units
(iii) 6 credit points of 2000-level units according to the following rules:
(a) 6 credit points of 2000-level biochemistry units or
(b) 6 credit points of MEDS coded units for student in the Medical Science stream
(iv) 6 credit points of 3000-level minor selective units from depth units
(v) 6 credit points of 3000-level minor selective units from breadth units

Units of study

The units of study are listed below.

1000-level units of study

Core
CHEM1011 Fundamentals of Chemistry 1A

Credit points: 6 Teacher/Coordinator: Dr Toby Hudson Session: Semester 1 Classes: 3x1-hr lectures; 1x1-hr tutorial per week; 1x3-hr practical per week for 9 weeks Prohibitions: CHEM1001 or CHEM1101 or CHEM1901 or CHEM1903 or CHEM1109 or CHEM1111 or CHEM1911 or CHEM1991 Assumed knowledge: There is no assumed knowledge of chemistry for this unit of study but students who have not completed HSC Chemistry (or equivalent) are strongly advised to take the Chemistry Bridging Course (offered in February). Assessment: quizzes, attendance, laboratory log book, exam Mode of delivery: Normal (lecture/lab/tutorial) day
Note: Students who have not completed HSC Chemistry (or equivalent) are strongly advised to take the Chemistry Bridging Course (offered in February, and online year-round, see https://sydney.edu.au/students/bridging-courses.html).
Chemistry describes how and why things happen from a molecular perspective. Chemistry underpins all aspects of the natural and physical world, and provides the basis for new technologies and advances in the life, medical and physical sciences, engineering, and industrial processes. This unit of study will equip you with the fundamental knowledge and skills in chemistry for broad application. You will learn about atomic theory, structure and bonding, equilibrium, processes occurring in solutions, and the functional groups of molecules. You will develop experimental design, conduct and analysis skills in chemistry through experiments that ask and answer questions about the chemical nature and processes occurring around you. Through inquiry, observation and measurement, you will better understand natural and physical world and will be able to apply this understanding to real-world problems and solutions. This unit of study is directed toward students whose chemical background is weak (or non-existent). Compared to the mainstream Chemistry 1A, the theory component of this unit begins with more fundamental concepts, and does not cover, or goes into less detail about some topics. Progression to intermediate chemistry from this unit and Fundamentals of Chemistry 1B requires completion of an online supplementary course.
Textbooks
Recommended textbook: Blackman, Bottle, Schmid, Mocerino and Wille,Chemistry, 3rd Edition, 2015 (John Wiley) ISBN: 978-0-7303-1105-8 (paperback) or 978-0-7303-2492-8 (e-text)
CHEM1111 Chemistry 1A

Credit points: 6 Teacher/Coordinator: Dr Toby Hudson Session: Intensive January,Semester 1,Semester 2 Classes: 3x1-hr lectures; 1x1-hr tutorial per week; 1x3-hr practical per week for 9 weeks Prohibitions: CHEM1001 or CHEM1101 or CHEM1901 or CHEM1903 or CHEM1109 or CHEM1011 or CHEM1911 or CHEM1991 Assumed knowledge: Students who have not completed HSC Chemistry (or equivalent) and HSC Mathematics (or equivalent) are strongly advised to take the Chemistry and Mathematics Bridging Courses (offered in February) Assessment: quizzes, attendance, laboratory log book, exam Mode of delivery: Normal (lecture/lab/tutorial) day
Note: Students who have not completed secondary school chemistry are strongly advised to instead complete Fundamentals of Chemistry 1A in the first semester of the calendar year (unless you require 12 credit points of Chemistry and are commencing in semester 2). You should also take the Chemistry Bridging Course in advance (offered in February, and online year-round https://sydney.edu.au/students/bridging-courses.html).
Chemistry describes how and why things happen from a molecular perspective. Chemistry underpins all aspects of the natural and physical world, and provides the basis for new technologies and advances in the life, medical and physical sciences, engineering, and industrial processes. This unit of study will further develop your knowledge and skills in chemistry for application to life and medical sciences, engineering, and further study in chemistry. You will learn about nuclear and radiation chemistry, wave theory, atomic orbitals, spectroscopy, bonding, enthalpy and entropy, equilibrium, processes occurring in solutions, and the functional groups in carbon chemistry. You will develop experimental design, conduct and analysis skills in chemistry through experiments that ask and answer questions like how do dyes work, how do we desalinate water, how do we measure the acid content in foods, how do we get the blue in a blueprint, and how do we extract natural products from plants? Through inquiry, observation and measurement, you will understand the 'why' and the 'how' of the natural and physical world and will be able to apply this understanding to real-world problems and solutions. This unit of study is directed toward students with a satisfactory prior knowledge of the HSC chemistry course.
Textbooks
Recommended textbook: Blackman, Bottle, Schmid, Mocerino and Wille,Chemistry, 3rd Edition, 2015 (John Wiley) ISBN: 978-0-7303-1105-8 (paperback) or 978-0-7303-2492-8 (e-text)
CHEM1911 Chemistry 1A (Advanced)

Credit points: 6 Teacher/Coordinator: Dr Toby Hudson Session: Semester 1 Classes: 3x1-hr lectures and 1x1-hr tutorial per week; 1x3-hr practical per week for 9 weeks Prohibitions: CHEM1001 or CHEM1101 or CHEM1901 or CHEM1903 or CHEM1109 or CHEM1011 or CHEM1111 or CHEM1991 Assumed knowledge: 80 or above in HSC Chemistry or equivalent Assessment: quizzes, attendance, laboratory log book, exam Mode of delivery: Normal (lecture/lab/tutorial) day
Note: Department permission required for enrolment
Chemistry describes how and why things happen from a molecular perspective. Chemistry underpins all aspects of the natural and physical world, and provides the basis for new technologies and advances in sciences, engineering, and industrial processes. This unit of study will further develop your knowledge and skills in chemistry for broad application, including further study in chemistry. You will learn about nuclear and radiation chemistry, wave theory, atomic orbitals, spectroscopy, bonding, enthalpy and entropy, equilibrium, processes occurring in solutions, and the functional groups of molecules. You will develop experimental design, conduct and analysis skills in chemistry through experiments that ask and answer questions about the chemical nature and processes occurring around you. Through inquiry, observation and measurement, you will better understand natural and physical world and will be able to apply this understanding to real-world problems and solutions. This unit of study is directed toward students with a good secondary performance both overall and in chemistry or science. Students in this category are expected to do this unit rather than Chemistry 1A. Compared to the mainstream Chemistry 1A, the theory component of this unit provides a higher level of academic rigour and makes broader connections between topics.
Textbooks
Recommended textbook: Blackman, Bottle, Schmid, Mocerino and Wille,Chemistry, 3rd Edition, 2015 (John Wiley) ISBN: 978-0-7303-1105-8 (paperback) or 978-0-7303-2492-8 (e-text)
CHEM1991 Chemistry 1A (Special Studies Program)

Credit points: 6 Teacher/Coordinator: Dr Toby Hudson Session: Semester 1 Classes: 3x1-hr lectures; 1x1-hr tutorial per week; 1x3hr practical per week for 12 weeks Prohibitions: CHEM1001 or CHEM1101 or CHEM1901 or CHEM1903 or CHEM1109 or CHEM1011 or CHEM1111 or CHEM1911 Assumed knowledge: 90 or above in HSC Chemistry or equivalent Assessment: quizzes, attendance, presentations, exam Mode of delivery: Normal (lecture/lab/tutorial) day
Note: Department permission required for enrolment
Chemistry describes how and why things happen from a molecular perspective. Chemistry underpins all aspects of the natural and physical world, and provides the basis for new technologies and advances in the life, medical and physical sciences, engineering, and industrial processes. This unit of study will further develop your knowledge and skills in chemistry for application to life and medical sciences, engineering, and further study in chemistry. You will learn about nuclear and radiation chemistry, wave theory, atomic orbitals, spectroscopy, bonding, enthalpy and entropy, equilibrium, processes occurring in solutions, and the functional groups in carbon chemistry. You will develop experimental design, conduct and analysis skills in chemistry in small group projects. The laboratory program is designed to extend students who already have chemistry laboratory experience, and particularly caters for students who already show a passion and enthusiasm for research chemistry, as well as aptitude as demonstrated by high school chemistry results. Entry to Chemistry 1A (Special Studies Program) is restricted to a small number of students with an excellent school record in Chemistry, and applications must be made to the School of Chemistry. The practical work syllabus for Chemistry 1A (Special Studies Program) is very different from that for Chemistry 1A and Chemistry 1A (Advanced) and consists of special project-based laboratory exercises. All other unit of study details are the same as those for Chemistry 1A (Advanced).
Textbooks
Recommended textbook: Blackman, Bottle, Schmid, Mocerino and Wille,Chemistry, 3rd Edition, 2015 (John Wiley) ISBN: 978-0-7303-1105-8 (paperback) or 978-0-7303-2492-8 (e-text)
BIOL1007 From Molecules to Ecosystems

Credit points: 6 Teacher/Coordinator: Dr Osu Lilje Session: Semester 2 Classes: 2-3 lectures per week and online material and 12 x 3-hour practicals Prohibitions: BIOL1907 or BIOL1997 Assumed knowledge: HSC Biology. Students who have not completed HSC Biology (or equivalent) are strongly advised to take the Biology Bridging Course (offered in February). Assessment: quizzes (15%), communication assessments (35%), proficiency assessment (10%), final exam (40%) Mode of delivery: Normal (lecture/lab/tutorial) day
Paradigm shifts in biology have changed the emphasis from single biomolecule studies to complex systems of biomolecules, cells and their interrelationships in ecosystems of life. Such an integrated understanding of cells, biomolecules and ecosystems is key to innovations in biology. Life relies on organisation, communication, responsiveness and regulation at every level. Understanding biological mechanisms, improving human health and addressing the impact of human activity are the great challenges of the 21st century. This unit will investigate life at levels ranging from cells, and biomolecule ecosystems, through to complex natural and human ecosystems. You will explore the importance of homeostasis in health and the triggers that lead to disease and death. You will learn the methods of cellular, biomolecular, microbial and ecological investigation that allow us to understand life and discover how expanding tools have improved our capacity to manage and intervene in ecosystems for our own health and organisms in the environment that surround and support us . You will participate in inquiry-led practicals that reinforce the concepts in the unit. By doing this unit you will develop knowledge and skills that will enable you to play a role in finding global solutions that will impact our lives.
Textbooks
Please see unit outline on LMS
BIOL1907 From Molecules to Ecosystems (Advanced)

Credit points: 6 Teacher/Coordinator: Dr Claudia Keitel Session: Semester 2 Classes: 2-3 lectures per week and online material and 12 x 3-hour practicals Prohibitions: BIOL1007 or BIOL1997 Assumed knowledge: 85 or above in HSC Biology or equivalent Assessment: quizzes (14%), communication assessments (36%), proficiency assessment (10%), final exam (40%) Mode of delivery: Normal (lecture/lab/tutorial) day
Note: Department permission required for enrolment
Paradigm shifts in biology have changed the emphasis from single biomolecule studies to complex systems of biomolecules, cells and their interrelationships in ecosystems of life. Such an integrated understanding of cells, biomolecules and ecosystems is key to innovations in biology. Life relies on organisation, communication, responsiveness and regulation at every level. Understanding biological mechanisms, improving human health and addressing the impact of human activity are the great challenges of the 21st century. This unit will investigate life at levels ranging from cells, and biomolecule ecosystems, through to complex natural and human ecosystems. You will explore the importance of homeostasis in health and the triggers that lead to disease and death. You will learn the methods of cellular, biomolecular, microbial and ecological investigation that allow us to understand life and discover how expanding tools have improved our capacity to manage and intervene in ecosystems for our own health and organisms in the environment that surround and support us . This unit of study has the same overall structure as BIOL1007 but material is discussed in greater detail and at a more advanced level. The content and nature of these components may vary from year to year.
Textbooks
Please see unit outline on LMS
BIOL1997 From Molecules to Ecosystems (SSP)

Credit points: 6 Teacher/Coordinator: Dr Emma Thompson Session: Semester 2 Classes: 2-3 lectures per week; online material; and 12 x 3-hour practicals Prohibitions: BIOL1007 or BIOL1907 Assumed knowledge: 90 or above in HSC Biology or equivalent Assessment: One 2-hour exam (40%), project report which includes written report and presentation (60%) Mode of delivery: Normal (lecture/lab/tutorial) day
Note: Department permission required for enrolment
Paradigm shifts in biology have changed the emphasis from single biomolecule studies to complex systems of biomolecules, cells and their interrelationships in ecosystems of life. Such an integrated understanding of cells, biomolecules and ecosystems is key to innovations in biology. Life relies on organisation, communication, responsiveness and regulation at every level. Understanding biological mechanisms, improving human health and addressing the impact of human activity are the great challenges of the 21st century. This unit will investigate life at levels ranging from cells, and biomolecule ecosystems, through to complex natural and human ecosystems. You will explore the importance of homeostasis in health and the triggers that lead to disease and death. You will learn the methods of cellular, biomolecular, microbial and ecological investigation that allow us to understand life and intervene in ecosystems to improve health. The same theory will be covered as in the advanced stream but in this Special Studies Unit, the practical component is a research project. The research will be a synthetic biology project investigating genetically engineered organisms. Students will have the opportunity to develop higher level generic skills in computing, communication, critical analysis, problem solving, data analysis and experimental design.
Textbooks
Please see unit outline on LMS

2000-level units of study

Core
BCMB2002 Proteins in Cells

Credit points: 6 Teacher/Coordinator: Dr Sandro Ataide Session: Semester 2 Classes: Two 1-hour lectures per week; one 4-hour practical/tutorial session per week Prerequisites: 6cp of (BIOL1XX7 or MBLG1XXX) and 6cp of (CHEM1XX1 or CHEM1903) Prohibitions: BCHM2071 or BCHM2971 or BCMB2902 Assessment: Assignments, skills-based assessment, quiz, final exam Mode of delivery: Normal (lecture/lab/tutorial) day
A single human cell contains billions of protein molecules that are constantly in motion. Why so many? What are they doing? And, how are they doing it? In simple terms, proteins define the function of and drive almost every process within cells. In this unit of study you will learn about the biochemistry of proteins in their natural environment - within cells - with a focus on eukaryotes including plant and other cell types. You will discover the dynamic interplay within and between proteins and other cellular components and how the physical properties of proteins dictate function. You will discover how proteins are compartmentalized, modified, folded, transported in and between cells, the mechanisms by which proteins regulate biological activities, interact and transport molecules across membranes, and how mutations in proteins can lead to pathological consequences. Our practicals, other guided and online learning sessions will introduce you to a wide range of currently utilised techniques for protein biochemistry ranging from protein visualization, quantification, purification and enzymatic activity, to in silico studies and cellular targeting experiments. By the end of this unit you will be equipped with foundational skills and knowledge to support your studies in the cellular and molecular biosciences.
Textbooks
Lehninger Principles of Biochemistry 7th edition (2016) David L. Nelson Michael M. Cox Macmillan (ISBN-10: 1-4641-2611-9; ISBN-13: 978-1-4641-2611-6)
BCMB2902 Proteins in Cells (Advanced)

Credit points: 6 Teacher/Coordinator: Dr Sandro Ataide Session: Semester 2 Classes: Two 1-hour lectures per week; one 4-hour practical/tutorial session per week Prerequisites: A mark of at least 70 from (BIOL1XX7 or MBLG1XX1) and (CHEM1XX1 or CHEM1903) Prohibitions: BCHM2071 or BCHM2971 or BCMB2002 Assessment: Assignment, skills-based assessment, quiz, exam Mode of delivery: Normal (lecture/lab/tutorial) day
A single human cell contains billions of protein molecules that are constantly in motion. Why so many? What are they doing? And, how are they doing it? In simple terms, proteins define the function of and drive almost every process within cells. In this unit of study you will learn about the biochemistry of proteins in their natural environment - within cells - with a focus on eukaryotes including plant and other cell types. You will discover the dynamic interplay within and between proteins and other cellular components and how the physical properties of proteins dictate function. You will discover how proteins are compartmentalized, modified, folded, transported in and between cells, the mechanisms by which proteins regulate biological activities, interact and transport molecules across membranes, and how mutations in proteins can lead to pathological consequences. There will be a research-focused approach to the advanced practical component, including real and virtual extensions to key experiments. This approach will continue in the lecture series with several unique advanced lectures covering current research topics. You will further investigate a selected area of interest from these topics using original source material and present your findings through an oral presentation in dedicated advanced tutorials.
Textbooks
Lehninger Principles of Biochemistry 7th edition (2016) David L. Nelson Michael M. Cox Macmillan (ISBN-10: 1-4641-2611-9; ISBN-13: 978-1-4641-2611-6)
Biochemistry
BCMB2001 Biochemistry and Molecular Biology

Credit points: 6 Teacher/Coordinator: Dr Dale Hancock Session: Semester 1 Classes: Three lectures per week; one 4-hour practical and one 1-hour tutorial session per fortnight Prerequisites: 6cp of (BIOL1XX7 or MBLG1XXX) and 6cp of (CHEM1XX1 or CHEM1903) Prohibitions: BCHM2072 or BCHM2972 or MBLG2071 or MBLG2971 or BMED2405 or BCMB2901 or MEDS2003 Assessment: Assignments, skills-based assessment, quizzes, exam Mode of delivery: Normal (lecture/lab/tutorial) day
Without cells, life as we know it would not exist. These dynamic assemblies, packed with biological molecules are constantly in action. But how do cells work? Why is the food that you eat so important for cellular function? How is information transmitted from generation to generation? And, what happens as a result of disease or genetic mutation? In this unit of study you will learn how cells work at the molecular level, with an emphasis on human biochemistry and molecular biology. We will focus initially on cellular metabolism and how cells extract and store energy from fuels like fats and carbohydrates, how the use of fuels is modulated in response to exercise, starvation and disease, and how other key metabolites are processed. Then we will explore how genetic information is regulated in eukaryotes, including replication, transcription and translation, and molecular aspects of the cell cycle, mitosis and meiosis. Our practicals, along with other guided and online learning sessions will introduce you to widely applied and cutting edge tools that are essential for modern biochemistry and molecular biology. By the end of this unit you will be equipped with foundational skills and knowledge to support your studies in the life and medical sciences.
Textbooks
Stryer Biochemistry 8th Edition ISBN-13:978-1-4641-2610-9
BCMB2901 Biochemistry and Molecular Biology (Advanced)

Credit points: 6 Teacher/Coordinator: Dr Dale Hancock Session: Semester 1 Classes: Three lectures per week; one 4-hour practical and one 1-hour tutorial session per fortnight Prerequisites: A mark of at least 70 from (BIOL1XX7 or MBLG1XX1) and (CHEM1XX1 or CHEM1903) Prohibitions: BCHM2072 or BCHM2972 or MBLG2071 or MBLG2971 or BMED2405 or BCMB2001 or MEDS2003 Assessment: Assignments, quiz, skills-based assessment, exam Mode of delivery: Normal (lecture/lab/tutorial) day
Without cells, life as we know it would not exist. These dynamic assemblies, packed with biological molecules are constantly in action. But how do cells work? Why is the food that you eat so important for cellular function? How is information transmitted from generation to generation? And, what happens as a result of disease or genetic mutation? In this unit of study you will learn how cells work at the molecular level, with an emphasis on human biochemistry and molecular biology. We will focus initially on cellular metabolism and how cells extract and store energy from fuels like fats and carbohydrates, how the use of fuels is modulated in response to exercise, starvation and disease, and how other key metabolites are processed. Then we will explore how genetic information is regulated in eukaryotes, including replication, transcription and translation, and molecular aspects of the cell cycle, mitosis and meiosis. The advanced laboratory component will provide students with an authentic research laboratory experience while in the theory component, current research topics will be presented in a problem-based format through dedicated advanced tutorial sessions. This material will be assessed by creative student-centered activities supported by eLearning platforms.
Textbooks
Stryer Biochemistry 8th Edition ISBN-13:978-1-4641-2610-9
MEDS coded
MEDS2003 Biochemistry and Molecular Biology

Credit points: 6 Teacher/Coordinator: Dr Dale Hancock Session: Semester 1 Classes: Three lectures per week; one 4-hour practical session and 1 h tutorial per fortnight Prerequisites: 6p from (BIOL1XX7 or MBLG1XX1) and 6cp of (CHEM1XX1 or CHEM1903) Prohibitions: BCHM2072 or BCHM2972 or MBLG2071 or MBLG2971 or BMED2405 or BCMB2001 or BCMB2901 or BMED2804 Assessment: Group presentation (5%), In-class continuous assessment (25%), PeerWise MCQ design (10%), ELMA design essay and interpretation (10%), final exam (50%) Mode of delivery: Normal (lecture/lab/tutorial) day
Without cells, life as we know it would not exist. These dynamic assemblies, packed with biological molecules are constantly in action. But how do cells work? Why is the food that you eat so important for cellular function? How is information transmitted from generation to generation? What happens as a result of disease or genetic mutation? In this unit of study you will learn how cells work at the molecular level, with an emphasis on human biochemistry and molecular biology. We will focus initially on cellular metabolism and how cells extract and store energy from fuels like fats and carbohydrates, how fuel use is modulated in response to exercise, starvation and disease, and how other key metabolites are processed. Then we will explore how genetic information is regulated in eukaryotes, including replication, transcription and translation, and molecular aspects of the cell cycle, mitosis and meiosis. Our practicals, along with other guided and online learning sessions will introduce you to widely applied and cutting-edge tools that are essential for modern biochemistry and molecular biology. By the end of this unit you will be equipped with foundational skills and knowledge to support your studies in the medical and life sciences.
Textbooks
Canvas, ELN Peerwise Site, Blackboard LMS Textbook: Biochemistry - Berg, Tymoczko, Gatto, Stryer 8th Ed or higher Wikipedia

3000-level units of study

Major core
BCMB3001 Gene and Genome Regulation

Credit points: 6 Teacher/Coordinator: Dr Tara Christie Session: Semester 1 Classes: lecture 2h/week, lab 6h/fortnight for 12 weeks Prerequisites: 6 credit points from (BCMB2X01 or BMED2802 or MBLG2X01 or MEDS2003) and 6 credit points from (BCHM2X71 or BCHM2X72 or BCHM3XXX or BCMB2X02 or BCMB3XXX or BIOL2X29 or BMED2401 or BMED2405 or GEGE2X01 or MBLG2XXX or MEDS2002 or PCOL2X21 or QBIO2001) Prohibitions: BCHM3X71 or BCMB3901 Assumed knowledge: Intermediate biochemistry and molecular biology Assessment: 3 x laboratory reports (6% each), online quiz (2%), 1000-wd formal report (10%), presentation (5%), 6 x in-semester quizzes (2% each), final exam (53%) Mode of delivery: Normal (lecture/lab/tutorial) day
Virtually every cell in your body contains the same DNA, but each one of your cell types uses a distinct subset of genes to define its function throughout its lifetime at every step along its developmental pathway. This unit of study will lead you to appreciate the mechanisms by which cells switch on or switch off genes at different times, in different places and in response to different signals. You will discover how our cells walk the fine line between repairing genetic damage and generating genetic diversity. You will also explore how manipulation of the genome through natural or targeted mutation can contribute to, prevent or treat disease. Our practicals, together with other guided and online learning sessions will introduce you to a wide range of currently utilised techniques for modern molecular biology, ranging from laboratory-based experiments to bioinformatics, in silico and virtual reality studies. By the end of this unit you will be equipped with senior level skills and knowledge to support your studies and careers in the cellular and molecular biosciences.
BCMB3901 Gene and Genome Regulation (Advanced)

Credit points: 6 Teacher/Coordinator: Dr Tara Christie Session: Semester 1 Classes: lecture 2h/week, lab 6h/fortnight for 12 weeks Prerequisites: An average mark of 75 or above in [6 credit points from (BCMB2X01 or BMED2802 or MBLG2X01 or MEDS2003) and 6 credit points from (BCHM2X71 or BCHM2X72 or BCHM3XXX or BCMB2X02 or BCMB3XXX or BIOL2X29 or BMED2401 or BMED2405 or GEGE2X01 or MBLG2XXX or MEDS2002 or PCOL2X21 or QBIO2001)] Prohibitions: BCHM3X71 or BCMB3001 Assumed knowledge: Intermediate Biochemistry (2000 level). Assessment: 3 x laboratory reports (6% each), online quiz (2%), 1000-wd formal report (10%), presentation (5%), 6 x in-semester quizzes (2% each), final exam (53%) Mode of delivery: Normal (lecture/lab/tutorial) day
Virtually every cell in your body contains the same DNA, but each one of your cell types uses a distinct subset of genes to define its function throughout its lifetime at every step along its developmental pathway. This unit of study will lead you to appreciate the mechanisms by which cells switch on or switch off genes at different times, in different places and in response to different signals. You will discover how our cells walk the fine line between repairing genetic damage and generating genetic diversity. You will also explore how manipulation of the genome through natural or targeted mutation can contribute to, prevent or treat disease. Our practicals, together with other guided and online learning sessions will introduce you to a wide range of currently utilised techniques for modern molecular biology, ranging from laboratory-based experiments to bioinformatics, in silico and virtual reality studies. By the end of this unit you will be equipped with senior level skills and knowledge to support your studies and careers in the cellular and molecular biosciences. Gene and Genome Regulation (Advanced) has the same overall structure and lecture content as BCMB3001 but the material is discussed in greater detail and at a more advanced level. Students enrolled in BCMB3901 participate in a partially varied practical and tutorial program that focuses on developing skills in experimental design, critical thinking, data analysis and communication.
BCMB3002 Protein Function and Engineering

Credit points: 6 Teacher/Coordinator: Prof Jacqui Matthews Session: Semester 1 Classes: lecture 2 h/week, lab 6 h/fortnight for 12 weeks Prerequisites: 6 credit points from (BCMB2X02 or BCHM2X71) and 6 credit points from (BCHM2X72 or BCHM3XXX or BCMB3XXX or BIOL2X29 or BMED2401 or BMED2405 or GEGE2X01 or MBLG2X01 or MEDS2002 or PCOL2X21 or QBIO2001) Prohibitions: BCHM3X81 or BCMB3902 Assumed knowledge: Intermediate biochemistry and molecular biology Assessment: 1000-wd lab report (10%), 2 x in-semester quizzes (theory; 5% each), skills-based task (theory of practical component; 10%), 4 x 400-wd short lab report (10%), group presentation and individual report (10%), final exam (50%) Mode of delivery: Normal (lecture/lab/tutorial) day
Proteins are the major doing molecules in biology. Their molecular make-up gives them a much more diverse set of properties than any other biological or synthetic polymer, leading to a vast array of different structures and functions. In this unit of study, you will learn about the structure, dynamics and interactions of proteins, and how those properties influence their myriad roles in nature. You will discover how these complex molecules are thought to have evolved, how they are made and dismantled, how they fold, and drive key processes inside and outside cells. You will also explore how the properties of proteins can be modulated by other molecules, or engineered to develop proteins with new functions or properties for use in biotechnology, medicine, bioremediation and industry. Our practicals, other guided and online learning sessions will introduce you to a wide range of currently utilised techniques for protein biochemistry ranging from protein visualization, quantification, purification and enzymatic activity, to in silico and virtual reality studies. By the end of this unit you will be equipped with senior level skills and knowledge to support your studies and careers in the cellular and molecular biosciences.
BCMB3902 Protein Function and Engineering (Advanced)

Credit points: 6 Teacher/Coordinator: Prof Jacqui Matthews Session: Semester 1 Classes: lecture 2 h/week, lab 6 h/fortnight for 12 weeks, 2-4 additional tutorial/online discussion groups throughout the semester Prerequisites: An average mark of 75 or above in [6 credit points from (BCMB2X02 or BCHM2X71) and 6 credit points from (BCHM2X71 or BCHM2X72 or BCHM3XXX or BCMB3XXX or BIOL2X29 or BMED2401 or BMED2405 or GEGE2X01 or MBLG2X01 or MEDS2002 or PCOL2X21 or QBIO2001)] Prohibitions: BCHM3X81 or BCMB3002 Assumed knowledge: Intermediate Biochemistry (2000 level). Assessment: 1000-wd lab report (10%), 2 x in-semester quizzes (theory; 5% each), skills-based task (theory of practical component; 10%), 4 x 400-wd short lab report (10%), group presentation and individual report (10%), final exam (50%) Mode of delivery: Normal (lecture/lab/tutorial) day
Proteins are the major doing molecules in biology. Their molecular make-up gives them a much more diverse set of properties than any other biological or synthetic polymer, leading to a vast array of different structures and functions. In this unit of study, you will learn about the structure, dynamics and interactions of proteins, and how those properties influence their myriad roles in nature. You will discover how these complex molecules are thought to have evolved, how they are made and dismantled, how they fold, and drive key processes inside and outside cells. You will also explore how the properties of proteins can be modulated by other molecules, or engineered to develop proteins with new functions or properties for use in biotechnology, medicine, bioremediation and industry. Our practicals, other guided and online learning sessions will introduce you to a wide range of currently utilised techniques for protein biochemistry ranging from protein visualization, quantification, purification and enzymatic activity, to in silico and virtual reality studies. By the end of this unit you will be equipped with senior level skills and knowledge to support your studies and careers in the cellular and molecular biosciences. Protein Function and Engineering (Advanced) has the same overall structure as BCMB3002 but the material is discussed in greater detail and at a more advanced level. Students enrolled in BCMB3902 participate in a partially varied practical and tutorial program that focuses on developing skills in experimental design, critical thinking, data analysis and communication.
Major selective
BCMB3003 Biochemistry of Human Disease

Credit points: 6 Teacher/Coordinator: Dr Markus Hofer Session: Semester 2 Classes: lectures 2 hrs/week, practical 3 hrs/fortnight (up to 7 practicals in total per student) Prerequisites: 12 credit points from (BCHM2X71 or BCHM2X72 or BCMB2X01 or BCMB2X02 or MEDS2003 or MBLG2X01) or [6 cp (BCHM2X71 or BCHM2X72 or BCMB2X01 or BCMB2X02 or MEDS2003 or MBLG2X01) and 6 credit points from (AMED3001 or BCHM3XXX or BCMB3XXX or BIOL2X29 or BMED2401 and BMED2405 or GEGE2X01 or MEDS2002 or PCOL2X21 or QBIO2001)] or 12 credit points from (BMED2401 and BMED2405) Prohibitions: BCMB3903 or (BCHM3X72 and BCHM3X82) Assumed knowledge: Intermediate protein chemistry and biochemistry concepts Assessment: 2 x 200-wd lab book report (5% each), scientific paper (15%), in-class quiz (20%), final exam (55%) Mode of delivery: Normal (lecture/lab/tutorial) day
Diseases are ultimately the result of an imbalance of cellular function. Causes for such dysfunction are diverse and include mutations of our DNA, altered gene expression and external stimuli such as infection. This unit will investigate how defects in key cell functions including gene expression, signalling, biomolecular interactions and metabolic processes lead to diseases. The molecular causes and biochemical processes that underlie cancer, aging and neurodegeneration will be used to illustrate the relationships between these processes and how our understanding of these commonalities is allowing us to solve complex health problems. Associations to other diseases will be integrated into the course to give a broader understanding of how key biochemical processes are linked to a wide range of disorders. In the practicals you will use experimental approaches to study cell proliferation and death, protein misfolding, the hallmarks of cancer and some neurodegenerative diseases. By the end of this unit you will have gained foundational skills and knowledge that will support further studies and careers in the life and medical sciences.
BCMB3903 Biochemistry of Human Disease (Advanced)

Credit points: 6 Teacher/Coordinator: Dr Markus Hofer Session: Semester 2 Classes: lectures 2 hrs/week, practical 3 hours per fortnight (up to 7 practicals in total per student) , four one-hour seminars, one poster session to present poster Prerequisites: An average mark of 75 or above in [12 credit points from (BCHM2X71 or BCHM2X72 or BCMB2X01 or BCMB2X02 or MEDS2003 or MBLG2X01) or [6 credit points from (BCHM2X71 or BCHM2X72 or BCMB2X01 or BCMB2X02 or MEDS2003 or MBLG2X01) and 6 credit points from (AMED3001 or BCHM3XXX or BCMB3XXX or BIOL2X29 or BMED2401 and BMED2405 or GEGE2X01 or MEDS2002 or PCOL2X21 or QBIO2001)] or 12 credit points from (BMED2401 and BMED2405)] Prohibitions: BCMB3003 or (BCHM3X72 and BCHM3X82) Assumed knowledge: Students should understand basic concepts in human, mammalian, plant and/or prokaryotic biology. Students should have a basic understanding of the 'genome' and of the central dogma of molecular biology (gene transcription and protein translation). Additional knowledge of basic chemistry and protein biochemistry will be helpful. Assessment: 2 x 200-wd lab book report (3% each), poster design and presentation (7%), 400-wd written report (6%), 400-wd short essay (6%), in class quiz (20%), final exam (55%) Mode of delivery: Normal (lecture/lab/tutorial) day
Diseases are ultimately the result of an imbalance of cellular function. Causes for such dysfunction are diverse and include mutations of our DNA, altered gene expression and external stimuli such as infection. This unit will investigate how defects in key cell functions including gene expression, signalling, biomolecular interactions and metabolic processes lead to diseases. The molecular causes and biochemical processes that underlie cancer, aging and neurodegeneration will be used to illustrate the relationships between these processes and how our understanding of these commonalities is allowing us to solve complex health problems. Associations to other diseases will be integrated into the course to give a broader understanding of how key biochemical processes are linked to a wide range of disorders. In the practicals you will use experimental approaches to study cell proliferation and death, protein misfolding, the hallmarks of cancer and some neurodegenerative diseases. By the end of this unit you will have gained foundational skills and knowledge that will support further studies and careers in the life and medical sciences. The lecture component of this advanced unit will be the same as for the mainstream unit BCMB3003. In the practicals you will investigate similar concepts, however, the experiments are designed to cover a wider range of techniques, and you will analyse the results in more depth. You will present scientific findings in a poster session to academics from the School of Life and Environmental Sciences (SOLES). In addition, to relate the course content to current research and application, you will attend a series of four research seminars relating to the lecture content that will be given by experts in their field.
BCMB3004 Beyond The Genome

Credit points: 6 Teacher/Coordinator: Prof Stuart Cordwell Session: Semester 2 Classes: lectures 2 hrs/week, practicals 3 hrs/week Prerequisites: 12 credit points from (AMED3001 or BCHM2X71 or BCHM2X72 or BCHM3XXX or BCMB2X01 or BCMB2X02 or BCMB3XXX or BIOL2X29 or BMED2401 or BMED2405 or GEGE2X01 or MBLG2X01 or MEDS2002 or MEDS2003 or PCOL2X21 or QBIO2001) Prohibitions: BCHM3X92 or BCMB3904 Assumed knowledge: Intermediate protein chemistry and biochemistry concepts Assessment: 4 x in-practical reports (10%), take-home computational practical (5%), 1000-1500wd scientific report (10%), mid-semester quiz (10%), 1500-2000wd data analysis and interpretation scientific report (15%) final exam (50%) Mode of delivery: Normal (lecture/lab/tutorial) day
The sequencing of the human genome was a landmark achievement in science and medicine, marking the 'Age of Genomics'. Now we can access the blueprints for life, but need to uncover how those blueprints work, allowing organisms to respond to internal and external environmental changes, and how we can utilise this plethora of DNA sequence information to improve human and planetary health. This unit will investigate the function of the genome by examining the proteome, metabolome and beyond. You will investigate links between the central dogma of molecular biology and the complexities of living genomes - from modifications that massively increase diversity to the dynamic metabolome. You will explore fundamental cellular processes and discover how they are shaped by the proteome via gene expression, post-translational modification and protein complex formation. These processes will be examined in the context of human health and cardiovascular and metabolic disorders (e. g. type 2 diabetes) to demonstrate how global approaches can define, diagnose and help develop treatments for disease. You will practice methods employed in the post-genome era, including the 'Multi-omics' approaches that provide a global view of living systems, and discover how they are applied to solve problems in biology, biomedicine and agriculture. By the end of the unit students will understand why global 'omics approaches are needed in the post-genome era and know how best to apply such tools to given biological and biomedical problems.
BCMB3904 Beyond The Genome (Advanced)

Credit points: 6 Teacher/Coordinator: Prof Stuart Cordwell Session: Semester 2 Classes: lectures 2 hrs/week, practicals 3 hrs/week, 4 x 1 hr advanced tutorials, 8 x 1 hr advanced practicals Prerequisites: An average mark of 75 or above in 12 credit points from (AMED3001 or BCHM2X71 or BCHM2X72 or BCHM3XXX or BCMB2X01 or BCMB2X02 or BCMB3XXX or BIOL2X29 or BMED2401 or BMED2405 or GEGE2X01 or MBLG2X01 or MEDS2002 or MEDS2003 or PCOL2X21 or QBIO2001) Prohibitions: BCHM3X92 or BCMB3004 Assumed knowledge: Students should understand basic concepts in human, mammalian, plant and/or prokaryotic biology. Students should have a basic understanding of the 'genome' and of the central dogma of molecular biology (gene transcription and protein translation). Additional knowledge of basic chemistry and protein biochemistry will be helpful. Assessment: 4 x in-practical reports (10%), take-home computational practical (5%), 1000-1500wd scientific report (10%), mid-semester quiz (10%), 1500-2000wd data analysis and interpretation scientific report (15%), final exam (50%) Mode of delivery: Normal (lecture/lab/tutorial) day
The sequencing of the human genome was a landmark achievement in science and medicine, marking the 'Age of Genomics'. Now we can access the blueprints for life, but need to uncover how those blueprints work, allowing organisms to respond to internal and external environmental changes, and how we can utilise this plethora of DNA sequence information to improve human and planetary health. This unit will investigate the function of the genome by examining the proteome, metabolome and beyond. You will investigate links between the central dogma of molecular biology and the complexities of living genomes - from modifications that massively increase diversity to the dynamic metabolome. You will explore fundamental cellular processes and discover how they are shaped by the proteome via gene expression, post-translational modification and protein complex formation. These processes will be examined in the context of human health and cardiovascular and metabolic disorders (e. g. type 2 diabetes) to demonstrate how global approaches can define, diagnose and help develop treatments for disease. You will practice methods employed in the post-genome era, including the 'Multi-omics' approaches that provide a global view of living systems, and discover how they are applied to solve problems in biology, biomedicine and agriculture. Beyond the Genome (Advanced) has the same overall structure as BCMB3004 but focuses on a more advanced level of practical work, data analysis and interpretation, using cutting-edge technologies. By the end of the unit students will understand why global 'omics approaches are needed in the post-genome era and know how best to apply such tools to given biological and biomedical problems.
PCOL3012 Drug Design and Development

Credit points: 6 Teacher/Coordinator: A/Prof. Rachel Codd Session: Semester 1 Classes: Two 1 hour lectures and one 3 hour tutorial/practical per week. Prerequisites: (PCOL2011 or PCOL2021 or MEDS2002) or [BMED2401 and 6cp from (BMED2402 or BMED2405)] or 12cp from BCMB2XXX Prohibitions: PCOL3912 Assessment: One 2 hour exam, class and online quizzes, assignments (100%) Mode of delivery: Normal (lecture/lab/tutorial) day
This unit of study is designed to introduce students with a basic understanding of pharmacology to the field of medicinal chemistry associated with drug design and development. The course covers the fundamental aspects of drug discovery and development with reference to the essentials of chemistry and illustrates drug development with examples that include neuraminidase inhibitors and angiotensin converting enzyme inhibitors. The role of computers in drug design is emphasised by classwork and assignments on molecular modelling and structure-activity relationships. The course also extends to a section on the design of diverse pharmacological agents which include compounds for imaging by positron emission tomography (PET), and kinase inhibitors.
Textbooks
Patrick, Graham L. An Introduction to Medicinal Chemistry. 5th edition. Oxford University Press. 2013.
PCOL3912 Drug Design and Development (Advanced)

Credit points: 6 Teacher/Coordinator: A/Prof. Rachel Codd Session: Semester 1 Classes: Two 1 hour lectures and one 3 hour tutorial/practical per week. Prerequisites: a mark of 70 or above in {(PCOL2011 or PCOL2021 or MEDS2002) or [BMED2401 and 6cp from (BMED2402 or BMED2405)] or 12cp from BCMB2XXX} Prohibitions: PCOL3012 Assessment: One 2 hour exam, in class and online quizzes, assignments (100%) Mode of delivery: Normal (lecture/lab/tutorial) day
This unit will consist of the lecture and practical components of PCOL3012. Students will be set special advanced assignments related to the material covered in core areas. These may also involve advanced practical work or detailed investigation of a theoretical problem.
Textbooks
Patrick, Graham L. An Introduction to Medicinal Chemistry. 5th edition. Oxford University Press. 2013.
Interdisciplinary project
BCMB3888 Biochemistry and Molecular Biology Project

Credit points: 6 Session: Semester 2 Classes: 2hrs lectures and 3hrs workshop/group work per week Prerequisites: BCMB2XX1/MEDS2003 and BCMB2XX2 Assumed knowledge: 2000 level biochemistry and molecular biology Assessment: assignment/quiz (10%), group project report (20%), group project oral presentation (10%), team work participation and evaluation (20%), written exam (40%) Mode of delivery: Normal (lecture/lab/tutorial) day
Our ever-changing world requires knowledge that extends across multiple disciplines. This unit presents the opportunity to bring together the concepts and skills you have learnt in your discipline and apply them to a real-world problem; you will work on an authentic project involving biochemistry and molecular biology. In this unit, you will continue to understand and explore disciplinary knowledge, while also meeting and collaborating with students from across the University through project-based learning; identifying and solving problems, collecting and analysing data and communicating your findings to a diverse audience. All of these skills are highly valued by employers. This unit will foster the ability to work in interdisciplinary teams, and this is essential for both professional and research pathways in future.
SCPU3001 Science Interdisciplinary Project

Credit points: 6 Teacher/Coordinator: Prof Pauline Ross Session: Intensive February,Intensive July,Semester 1,Semester 2 Classes: The unit consists of one seminar/workshop per week with accompanying online materials and a project to be determined in consultation with the partner organisation and completed as part of a team with academic supervision. Prerequisites: Completion of 2000-level units required for at least one Science major. Assessment: group plan, group presentation, reflective journal, group project Mode of delivery: Normal (lecture/lab/tutorial) day
This unit is designed for students who are concurrently enrolled in at least one 3000-level Science Table A unit of study to undertake a project that allows them to work with one of the University's industry and community partners. Students will work in teams on a real-world problem provided by the partner. This experience will allow students to apply their academic skills and disciplinary knowledge to a real-world issue in an authentic and meaningful way. Participation in this unit will require students to submit an application to the Faculty of Science.
Minor selective depth
BCMB3001 Gene and Genome Regulation

Credit points: 6 Teacher/Coordinator: Dr Tara Christie Session: Semester 1 Classes: lecture 2h/week, lab 6h/fortnight for 12 weeks Prerequisites: 6 credit points from (BCMB2X01 or BMED2802 or MBLG2X01 or MEDS2003) and 6 credit points from (BCHM2X71 or BCHM2X72 or BCHM3XXX or BCMB2X02 or BCMB3XXX or BIOL2X29 or BMED2401 or BMED2405 or GEGE2X01 or MBLG2XXX or MEDS2002 or PCOL2X21 or QBIO2001) Prohibitions: BCHM3X71 or BCMB3901 Assumed knowledge: Intermediate biochemistry and molecular biology Assessment: 3 x laboratory reports (6% each), online quiz (2%), 1000-wd formal report (10%), presentation (5%), 6 x in-semester quizzes (2% each), final exam (53%) Mode of delivery: Normal (lecture/lab/tutorial) day
Virtually every cell in your body contains the same DNA, but each one of your cell types uses a distinct subset of genes to define its function throughout its lifetime at every step along its developmental pathway. This unit of study will lead you to appreciate the mechanisms by which cells switch on or switch off genes at different times, in different places and in response to different signals. You will discover how our cells walk the fine line between repairing genetic damage and generating genetic diversity. You will also explore how manipulation of the genome through natural or targeted mutation can contribute to, prevent or treat disease. Our practicals, together with other guided and online learning sessions will introduce you to a wide range of currently utilised techniques for modern molecular biology, ranging from laboratory-based experiments to bioinformatics, in silico and virtual reality studies. By the end of this unit you will be equipped with senior level skills and knowledge to support your studies and careers in the cellular and molecular biosciences.
BCMB3901 Gene and Genome Regulation (Advanced)

Credit points: 6 Teacher/Coordinator: Dr Tara Christie Session: Semester 1 Classes: lecture 2h/week, lab 6h/fortnight for 12 weeks Prerequisites: An average mark of 75 or above in [6 credit points from (BCMB2X01 or BMED2802 or MBLG2X01 or MEDS2003) and 6 credit points from (BCHM2X71 or BCHM2X72 or BCHM3XXX or BCMB2X02 or BCMB3XXX or BIOL2X29 or BMED2401 or BMED2405 or GEGE2X01 or MBLG2XXX or MEDS2002 or PCOL2X21 or QBIO2001)] Prohibitions: BCHM3X71 or BCMB3001 Assumed knowledge: Intermediate Biochemistry (2000 level). Assessment: 3 x laboratory reports (6% each), online quiz (2%), 1000-wd formal report (10%), presentation (5%), 6 x in-semester quizzes (2% each), final exam (53%) Mode of delivery: Normal (lecture/lab/tutorial) day
Virtually every cell in your body contains the same DNA, but each one of your cell types uses a distinct subset of genes to define its function throughout its lifetime at every step along its developmental pathway. This unit of study will lead you to appreciate the mechanisms by which cells switch on or switch off genes at different times, in different places and in response to different signals. You will discover how our cells walk the fine line between repairing genetic damage and generating genetic diversity. You will also explore how manipulation of the genome through natural or targeted mutation can contribute to, prevent or treat disease. Our practicals, together with other guided and online learning sessions will introduce you to a wide range of currently utilised techniques for modern molecular biology, ranging from laboratory-based experiments to bioinformatics, in silico and virtual reality studies. By the end of this unit you will be equipped with senior level skills and knowledge to support your studies and careers in the cellular and molecular biosciences. Gene and Genome Regulation (Advanced) has the same overall structure and lecture content as BCMB3001 but the material is discussed in greater detail and at a more advanced level. Students enrolled in BCMB3901 participate in a partially varied practical and tutorial program that focuses on developing skills in experimental design, critical thinking, data analysis and communication.
BCMB3002 Protein Function and Engineering

Credit points: 6 Teacher/Coordinator: Prof Jacqui Matthews Session: Semester 1 Classes: lecture 2 h/week, lab 6 h/fortnight for 12 weeks Prerequisites: 6 credit points from (BCMB2X02 or BCHM2X71) and 6 credit points from (BCHM2X72 or BCHM3XXX or BCMB3XXX or BIOL2X29 or BMED2401 or BMED2405 or GEGE2X01 or MBLG2X01 or MEDS2002 or PCOL2X21 or QBIO2001) Prohibitions: BCHM3X81 or BCMB3902 Assumed knowledge: Intermediate biochemistry and molecular biology Assessment: 1000-wd lab report (10%), 2 x in-semester quizzes (theory; 5% each), skills-based task (theory of practical component; 10%), 4 x 400-wd short lab report (10%), group presentation and individual report (10%), final exam (50%) Mode of delivery: Normal (lecture/lab/tutorial) day
Proteins are the major doing molecules in biology. Their molecular make-up gives them a much more diverse set of properties than any other biological or synthetic polymer, leading to a vast array of different structures and functions. In this unit of study, you will learn about the structure, dynamics and interactions of proteins, and how those properties influence their myriad roles in nature. You will discover how these complex molecules are thought to have evolved, how they are made and dismantled, how they fold, and drive key processes inside and outside cells. You will also explore how the properties of proteins can be modulated by other molecules, or engineered to develop proteins with new functions or properties for use in biotechnology, medicine, bioremediation and industry. Our practicals, other guided and online learning sessions will introduce you to a wide range of currently utilised techniques for protein biochemistry ranging from protein visualization, quantification, purification and enzymatic activity, to in silico and virtual reality studies. By the end of this unit you will be equipped with senior level skills and knowledge to support your studies and careers in the cellular and molecular biosciences.
BCMB3902 Protein Function and Engineering (Advanced)

Credit points: 6 Teacher/Coordinator: Prof Jacqui Matthews Session: Semester 1 Classes: lecture 2 h/week, lab 6 h/fortnight for 12 weeks, 2-4 additional tutorial/online discussion groups throughout the semester Prerequisites: An average mark of 75 or above in [6 credit points from (BCMB2X02 or BCHM2X71) and 6 credit points from (BCHM2X71 or BCHM2X72 or BCHM3XXX or BCMB3XXX or BIOL2X29 or BMED2401 or BMED2405 or GEGE2X01 or MBLG2X01 or MEDS2002 or PCOL2X21 or QBIO2001)] Prohibitions: BCHM3X81 or BCMB3002 Assumed knowledge: Intermediate Biochemistry (2000 level). Assessment: 1000-wd lab report (10%), 2 x in-semester quizzes (theory; 5% each), skills-based task (theory of practical component; 10%), 4 x 400-wd short lab report (10%), group presentation and individual report (10%), final exam (50%) Mode of delivery: Normal (lecture/lab/tutorial) day
Proteins are the major doing molecules in biology. Their molecular make-up gives them a much more diverse set of properties than any other biological or synthetic polymer, leading to a vast array of different structures and functions. In this unit of study, you will learn about the structure, dynamics and interactions of proteins, and how those properties influence their myriad roles in nature. You will discover how these complex molecules are thought to have evolved, how they are made and dismantled, how they fold, and drive key processes inside and outside cells. You will also explore how the properties of proteins can be modulated by other molecules, or engineered to develop proteins with new functions or properties for use in biotechnology, medicine, bioremediation and industry. Our practicals, other guided and online learning sessions will introduce you to a wide range of currently utilised techniques for protein biochemistry ranging from protein visualization, quantification, purification and enzymatic activity, to in silico and virtual reality studies. By the end of this unit you will be equipped with senior level skills and knowledge to support your studies and careers in the cellular and molecular biosciences. Protein Function and Engineering (Advanced) has the same overall structure as BCMB3002 but the material is discussed in greater detail and at a more advanced level. Students enrolled in BCMB3902 participate in a partially varied practical and tutorial program that focuses on developing skills in experimental design, critical thinking, data analysis and communication.
Minor selective breadth
BCMB3001 Gene and Genome Regulation

Credit points: 6 Teacher/Coordinator: Dr Tara Christie Session: Semester 1 Classes: lecture 2h/week, lab 6h/fortnight for 12 weeks Prerequisites: 6 credit points from (BCMB2X01 or BMED2802 or MBLG2X01 or MEDS2003) and 6 credit points from (BCHM2X71 or BCHM2X72 or BCHM3XXX or BCMB2X02 or BCMB3XXX or BIOL2X29 or BMED2401 or BMED2405 or GEGE2X01 or MBLG2XXX or MEDS2002 or PCOL2X21 or QBIO2001) Prohibitions: BCHM3X71 or BCMB3901 Assumed knowledge: Intermediate biochemistry and molecular biology Assessment: 3 x laboratory reports (6% each), online quiz (2%), 1000-wd formal report (10%), presentation (5%), 6 x in-semester quizzes (2% each), final exam (53%) Mode of delivery: Normal (lecture/lab/tutorial) day
Virtually every cell in your body contains the same DNA, but each one of your cell types uses a distinct subset of genes to define its function throughout its lifetime at every step along its developmental pathway. This unit of study will lead you to appreciate the mechanisms by which cells switch on or switch off genes at different times, in different places and in response to different signals. You will discover how our cells walk the fine line between repairing genetic damage and generating genetic diversity. You will also explore how manipulation of the genome through natural or targeted mutation can contribute to, prevent or treat disease. Our practicals, together with other guided and online learning sessions will introduce you to a wide range of currently utilised techniques for modern molecular biology, ranging from laboratory-based experiments to bioinformatics, in silico and virtual reality studies. By the end of this unit you will be equipped with senior level skills and knowledge to support your studies and careers in the cellular and molecular biosciences.
BCMB3901 Gene and Genome Regulation (Advanced)

Credit points: 6 Teacher/Coordinator: Dr Tara Christie Session: Semester 1 Classes: lecture 2h/week, lab 6h/fortnight for 12 weeks Prerequisites: An average mark of 75 or above in [6 credit points from (BCMB2X01 or BMED2802 or MBLG2X01 or MEDS2003) and 6 credit points from (BCHM2X71 or BCHM2X72 or BCHM3XXX or BCMB2X02 or BCMB3XXX or BIOL2X29 or BMED2401 or BMED2405 or GEGE2X01 or MBLG2XXX or MEDS2002 or PCOL2X21 or QBIO2001)] Prohibitions: BCHM3X71 or BCMB3001 Assumed knowledge: Intermediate Biochemistry (2000 level). Assessment: 3 x laboratory reports (6% each), online quiz (2%), 1000-wd formal report (10%), presentation (5%), 6 x in-semester quizzes (2% each), final exam (53%) Mode of delivery: Normal (lecture/lab/tutorial) day
Virtually every cell in your body contains the same DNA, but each one of your cell types uses a distinct subset of genes to define its function throughout its lifetime at every step along its developmental pathway. This unit of study will lead you to appreciate the mechanisms by which cells switch on or switch off genes at different times, in different places and in response to different signals. You will discover how our cells walk the fine line between repairing genetic damage and generating genetic diversity. You will also explore how manipulation of the genome through natural or targeted mutation can contribute to, prevent or treat disease. Our practicals, together with other guided and online learning sessions will introduce you to a wide range of currently utilised techniques for modern molecular biology, ranging from laboratory-based experiments to bioinformatics, in silico and virtual reality studies. By the end of this unit you will be equipped with senior level skills and knowledge to support your studies and careers in the cellular and molecular biosciences. Gene and Genome Regulation (Advanced) has the same overall structure and lecture content as BCMB3001 but the material is discussed in greater detail and at a more advanced level. Students enrolled in BCMB3901 participate in a partially varied practical and tutorial program that focuses on developing skills in experimental design, critical thinking, data analysis and communication.
BCMB3002 Protein Function and Engineering

Credit points: 6 Teacher/Coordinator: Prof Jacqui Matthews Session: Semester 1 Classes: lecture 2 h/week, lab 6 h/fortnight for 12 weeks Prerequisites: 6 credit points from (BCMB2X02 or BCHM2X71) and 6 credit points from (BCHM2X72 or BCHM3XXX or BCMB3XXX or BIOL2X29 or BMED2401 or BMED2405 or GEGE2X01 or MBLG2X01 or MEDS2002 or PCOL2X21 or QBIO2001) Prohibitions: BCHM3X81 or BCMB3902 Assumed knowledge: Intermediate biochemistry and molecular biology Assessment: 1000-wd lab report (10%), 2 x in-semester quizzes (theory; 5% each), skills-based task (theory of practical component; 10%), 4 x 400-wd short lab report (10%), group presentation and individual report (10%), final exam (50%) Mode of delivery: Normal (lecture/lab/tutorial) day
Proteins are the major doing molecules in biology. Their molecular make-up gives them a much more diverse set of properties than any other biological or synthetic polymer, leading to a vast array of different structures and functions. In this unit of study, you will learn about the structure, dynamics and interactions of proteins, and how those properties influence their myriad roles in nature. You will discover how these complex molecules are thought to have evolved, how they are made and dismantled, how they fold, and drive key processes inside and outside cells. You will also explore how the properties of proteins can be modulated by other molecules, or engineered to develop proteins with new functions or properties for use in biotechnology, medicine, bioremediation and industry. Our practicals, other guided and online learning sessions will introduce you to a wide range of currently utilised techniques for protein biochemistry ranging from protein visualization, quantification, purification and enzymatic activity, to in silico and virtual reality studies. By the end of this unit you will be equipped with senior level skills and knowledge to support your studies and careers in the cellular and molecular biosciences.
BCMB3902 Protein Function and Engineering (Advanced)

Credit points: 6 Teacher/Coordinator: Prof Jacqui Matthews Session: Semester 1 Classes: lecture 2 h/week, lab 6 h/fortnight for 12 weeks, 2-4 additional tutorial/online discussion groups throughout the semester Prerequisites: An average mark of 75 or above in [6 credit points from (BCMB2X02 or BCHM2X71) and 6 credit points from (BCHM2X71 or BCHM2X72 or BCHM3XXX or BCMB3XXX or BIOL2X29 or BMED2401 or BMED2405 or GEGE2X01 or MBLG2X01 or MEDS2002 or PCOL2X21 or QBIO2001)] Prohibitions: BCHM3X81 or BCMB3002 Assumed knowledge: Intermediate Biochemistry (2000 level). Assessment: 1000-wd lab report (10%), 2 x in-semester quizzes (theory; 5% each), skills-based task (theory of practical component; 10%), 4 x 400-wd short lab report (10%), group presentation and individual report (10%), final exam (50%) Mode of delivery: Normal (lecture/lab/tutorial) day
Proteins are the major doing molecules in biology. Their molecular make-up gives them a much more diverse set of properties than any other biological or synthetic polymer, leading to a vast array of different structures and functions. In this unit of study, you will learn about the structure, dynamics and interactions of proteins, and how those properties influence their myriad roles in nature. You will discover how these complex molecules are thought to have evolved, how they are made and dismantled, how they fold, and drive key processes inside and outside cells. You will also explore how the properties of proteins can be modulated by other molecules, or engineered to develop proteins with new functions or properties for use in biotechnology, medicine, bioremediation and industry. Our practicals, other guided and online learning sessions will introduce you to a wide range of currently utilised techniques for protein biochemistry ranging from protein visualization, quantification, purification and enzymatic activity, to in silico and virtual reality studies. By the end of this unit you will be equipped with senior level skills and knowledge to support your studies and careers in the cellular and molecular biosciences. Protein Function and Engineering (Advanced) has the same overall structure as BCMB3002 but the material is discussed in greater detail and at a more advanced level. Students enrolled in BCMB3902 participate in a partially varied practical and tutorial program that focuses on developing skills in experimental design, critical thinking, data analysis and communication.
BCMB3003 Biochemistry of Human Disease

Credit points: 6 Teacher/Coordinator: Dr Markus Hofer Session: Semester 2 Classes: lectures 2 hrs/week, practical 3 hrs/fortnight (up to 7 practicals in total per student) Prerequisites: 12 credit points from (BCHM2X71 or BCHM2X72 or BCMB2X01 or BCMB2X02 or MEDS2003 or MBLG2X01) or [6 cp (BCHM2X71 or BCHM2X72 or BCMB2X01 or BCMB2X02 or MEDS2003 or MBLG2X01) and 6 credit points from (AMED3001 or BCHM3XXX or BCMB3XXX or BIOL2X29 or BMED2401 and BMED2405 or GEGE2X01 or MEDS2002 or PCOL2X21 or QBIO2001)] or 12 credit points from (BMED2401 and BMED2405) Prohibitions: BCMB3903 or (BCHM3X72 and BCHM3X82) Assumed knowledge: Intermediate protein chemistry and biochemistry concepts Assessment: 2 x 200-wd lab book report (5% each), scientific paper (15%), in-class quiz (20%), final exam (55%) Mode of delivery: Normal (lecture/lab/tutorial) day
Diseases are ultimately the result of an imbalance of cellular function. Causes for such dysfunction are diverse and include mutations of our DNA, altered gene expression and external stimuli such as infection. This unit will investigate how defects in key cell functions including gene expression, signalling, biomolecular interactions and metabolic processes lead to diseases. The molecular causes and biochemical processes that underlie cancer, aging and neurodegeneration will be used to illustrate the relationships between these processes and how our understanding of these commonalities is allowing us to solve complex health problems. Associations to other diseases will be integrated into the course to give a broader understanding of how key biochemical processes are linked to a wide range of disorders. In the practicals you will use experimental approaches to study cell proliferation and death, protein misfolding, the hallmarks of cancer and some neurodegenerative diseases. By the end of this unit you will have gained foundational skills and knowledge that will support further studies and careers in the life and medical sciences.
BCMB3903 Biochemistry of Human Disease (Advanced)

Credit points: 6 Teacher/Coordinator: Dr Markus Hofer Session: Semester 2 Classes: lectures 2 hrs/week, practical 3 hours per fortnight (up to 7 practicals in total per student) , four one-hour seminars, one poster session to present poster Prerequisites: An average mark of 75 or above in [12 credit points from (BCHM2X71 or BCHM2X72 or BCMB2X01 or BCMB2X02 or MEDS2003 or MBLG2X01) or [6 credit points from (BCHM2X71 or BCHM2X72 or BCMB2X01 or BCMB2X02 or MEDS2003 or MBLG2X01) and 6 credit points from (AMED3001 or BCHM3XXX or BCMB3XXX or BIOL2X29 or BMED2401 and BMED2405 or GEGE2X01 or MEDS2002 or PCOL2X21 or QBIO2001)] or 12 credit points from (BMED2401 and BMED2405)] Prohibitions: BCMB3003 or (BCHM3X72 and BCHM3X82) Assumed knowledge: Students should understand basic concepts in human, mammalian, plant and/or prokaryotic biology. Students should have a basic understanding of the 'genome' and of the central dogma of molecular biology (gene transcription and protein translation). Additional knowledge of basic chemistry and protein biochemistry will be helpful. Assessment: 2 x 200-wd lab book report (3% each), poster design and presentation (7%), 400-wd written report (6%), 400-wd short essay (6%), in class quiz (20%), final exam (55%) Mode of delivery: Normal (lecture/lab/tutorial) day
Diseases are ultimately the result of an imbalance of cellular function. Causes for such dysfunction are diverse and include mutations of our DNA, altered gene expression and external stimuli such as infection. This unit will investigate how defects in key cell functions including gene expression, signalling, biomolecular interactions and metabolic processes lead to diseases. The molecular causes and biochemical processes that underlie cancer, aging and neurodegeneration will be used to illustrate the relationships between these processes and how our understanding of these commonalities is allowing us to solve complex health problems. Associations to other diseases will be integrated into the course to give a broader understanding of how key biochemical processes are linked to a wide range of disorders. In the practicals you will use experimental approaches to study cell proliferation and death, protein misfolding, the hallmarks of cancer and some neurodegenerative diseases. By the end of this unit you will have gained foundational skills and knowledge that will support further studies and careers in the life and medical sciences. The lecture component of this advanced unit will be the same as for the mainstream unit BCMB3003. In the practicals you will investigate similar concepts, however, the experiments are designed to cover a wider range of techniques, and you will analyse the results in more depth. You will present scientific findings in a poster session to academics from the School of Life and Environmental Sciences (SOLES). In addition, to relate the course content to current research and application, you will attend a series of four research seminars relating to the lecture content that will be given by experts in their field.
BCMB3004 Beyond The Genome

Credit points: 6 Teacher/Coordinator: Prof Stuart Cordwell Session: Semester 2 Classes: lectures 2 hrs/week, practicals 3 hrs/week Prerequisites: 12 credit points from (AMED3001 or BCHM2X71 or BCHM2X72 or BCHM3XXX or BCMB2X01 or BCMB2X02 or BCMB3XXX or BIOL2X29 or BMED2401 or BMED2405 or GEGE2X01 or MBLG2X01 or MEDS2002 or MEDS2003 or PCOL2X21 or QBIO2001) Prohibitions: BCHM3X92 or BCMB3904 Assumed knowledge: Intermediate protein chemistry and biochemistry concepts Assessment: 4 x in-practical reports (10%), take-home computational practical (5%), 1000-1500wd scientific report (10%), mid-semester quiz (10%), 1500-2000wd data analysis and interpretation scientific report (15%) final exam (50%) Mode of delivery: Normal (lecture/lab/tutorial) day
The sequencing of the human genome was a landmark achievement in science and medicine, marking the 'Age of Genomics'. Now we can access the blueprints for life, but need to uncover how those blueprints work, allowing organisms to respond to internal and external environmental changes, and how we can utilise this plethora of DNA sequence information to improve human and planetary health. This unit will investigate the function of the genome by examining the proteome, metabolome and beyond. You will investigate links between the central dogma of molecular biology and the complexities of living genomes - from modifications that massively increase diversity to the dynamic metabolome. You will explore fundamental cellular processes and discover how they are shaped by the proteome via gene expression, post-translational modification and protein complex formation. These processes will be examined in the context of human health and cardiovascular and metabolic disorders (e. g. type 2 diabetes) to demonstrate how global approaches can define, diagnose and help develop treatments for disease. You will practice methods employed in the post-genome era, including the 'Multi-omics' approaches that provide a global view of living systems, and discover how they are applied to solve problems in biology, biomedicine and agriculture. By the end of the unit students will understand why global 'omics approaches are needed in the post-genome era and know how best to apply such tools to given biological and biomedical problems.
BCMB3904 Beyond The Genome (Advanced)

Credit points: 6 Teacher/Coordinator: Prof Stuart Cordwell Session: Semester 2 Classes: lectures 2 hrs/week, practicals 3 hrs/week, 4 x 1 hr advanced tutorials, 8 x 1 hr advanced practicals Prerequisites: An average mark of 75 or above in 12 credit points from (AMED3001 or BCHM2X71 or BCHM2X72 or BCHM3XXX or BCMB2X01 or BCMB2X02 or BCMB3XXX or BIOL2X29 or BMED2401 or BMED2405 or GEGE2X01 or MBLG2X01 or MEDS2002 or MEDS2003 or PCOL2X21 or QBIO2001) Prohibitions: BCHM3X92 or BCMB3004 Assumed knowledge: Students should understand basic concepts in human, mammalian, plant and/or prokaryotic biology. Students should have a basic understanding of the 'genome' and of the central dogma of molecular biology (gene transcription and protein translation). Additional knowledge of basic chemistry and protein biochemistry will be helpful. Assessment: 4 x in-practical reports (10%), take-home computational practical (5%), 1000-1500wd scientific report (10%), mid-semester quiz (10%), 1500-2000wd data analysis and interpretation scientific report (15%), final exam (50%) Mode of delivery: Normal (lecture/lab/tutorial) day
The sequencing of the human genome was a landmark achievement in science and medicine, marking the 'Age of Genomics'. Now we can access the blueprints for life, but need to uncover how those blueprints work, allowing organisms to respond to internal and external environmental changes, and how we can utilise this plethora of DNA sequence information to improve human and planetary health. This unit will investigate the function of the genome by examining the proteome, metabolome and beyond. You will investigate links between the central dogma of molecular biology and the complexities of living genomes - from modifications that massively increase diversity to the dynamic metabolome. You will explore fundamental cellular processes and discover how they are shaped by the proteome via gene expression, post-translational modification and protein complex formation. These processes will be examined in the context of human health and cardiovascular and metabolic disorders (e. g. type 2 diabetes) to demonstrate how global approaches can define, diagnose and help develop treatments for disease. You will practice methods employed in the post-genome era, including the 'Multi-omics' approaches that provide a global view of living systems, and discover how they are applied to solve problems in biology, biomedicine and agriculture. Beyond the Genome (Advanced) has the same overall structure as BCMB3004 but focuses on a more advanced level of practical work, data analysis and interpretation, using cutting-edge technologies. By the end of the unit students will understand why global 'omics approaches are needed in the post-genome era and know how best to apply such tools to given biological and biomedical problems.
PCOL3012 Drug Design and Development

Credit points: 6 Teacher/Coordinator: A/Prof. Rachel Codd Session: Semester 1 Classes: Two 1 hour lectures and one 3 hour tutorial/practical per week. Prerequisites: (PCOL2011 or PCOL2021 or MEDS2002) or [BMED2401 and 6cp from (BMED2402 or BMED2405)] or 12cp from BCMB2XXX Prohibitions: PCOL3912 Assessment: One 2 hour exam, class and online quizzes, assignments (100%) Mode of delivery: Normal (lecture/lab/tutorial) day
This unit of study is designed to introduce students with a basic understanding of pharmacology to the field of medicinal chemistry associated with drug design and development. The course covers the fundamental aspects of drug discovery and development with reference to the essentials of chemistry and illustrates drug development with examples that include neuraminidase inhibitors and angiotensin converting enzyme inhibitors. The role of computers in drug design is emphasised by classwork and assignments on molecular modelling and structure-activity relationships. The course also extends to a section on the design of diverse pharmacological agents which include compounds for imaging by positron emission tomography (PET), and kinase inhibitors.
Textbooks
Patrick, Graham L. An Introduction to Medicinal Chemistry. 5th edition. Oxford University Press. 2013.
PCOL3912 Drug Design and Development (Advanced)

Credit points: 6 Teacher/Coordinator: A/Prof. Rachel Codd Session: Semester 1 Classes: Two 1 hour lectures and one 3 hour tutorial/practical per week. Prerequisites: a mark of 70 or above in {(PCOL2011 or PCOL2021 or MEDS2002) or [BMED2401 and 6cp from (BMED2402 or BMED2405)] or 12cp from BCMB2XXX} Prohibitions: PCOL3012 Assessment: One 2 hour exam, in class and online quizzes, assignments (100%) Mode of delivery: Normal (lecture/lab/tutorial) day
This unit will consist of the lecture and practical components of PCOL3012. Students will be set special advanced assignments related to the material covered in core areas. These may also involve advanced practical work or detailed investigation of a theoretical problem.
Textbooks
Patrick, Graham L. An Introduction to Medicinal Chemistry. 5th edition. Oxford University Press. 2013.