Cryptococcal Antigen in Serum and Cerebrospinal Fluid for Detecting Cryptococcal Meningitis in Adults Living With Human Immunodeficiency Virus: Systematic Review and Meta-Analysis of Diagnostic Test Accuracy Studies
Cryptococcal meningitis (CM), a life-threatening systemic, opportunistic fungal infection, occurs mainly in patients with defective cellular immunity. Cryptococcal antigen (CrAg) detection could direct the timely initiation of antifungal therapy.