Dr Jingjing You
Sydney Horizon Fellow
School of Medical Sciences and Save Sight Institute
Faculty of Medicine and Health
Jingjing You, PhD, GradCert RSCH MNGT&COMMERCIAL
3D bioprinting; biomaterial development; tissue engineering; advance manufacturing; machine learning; collagen; regenerative medicine, wound healing
Tissue engineering
Biomaterial
Matrix protein and cell interation
Eye Research
Machine learning
Light related clinical applications
Master/ PhD
1. Investigating the role of collagen in healthy and diseased tissues
2. Reconstruction of eye tissues using tissue engineering approach
3. Development of a sensitive platform for tear protein detction
4. Machine learning in diagnosing and monitoring diseases
5. Advance manufacturing on novel biomaterials
International Society of Eye Research
Tear Film and Ocular Surface Society
Digital Health and Informatics Network (DHIN)
ANZ Bioengineering Cornea Working Group - Founder
BIENCO (BioEngineeringCornea) - Founder
Major Funding awarded:
MRFF Frontier and Health 2023; $35Mil; CI-Project Lead for Collagen Production and bioengineering corneal endothelium
MRFF Frontier and Health 2021; near $1Mil- Stage 1CI-Project Lead for Collagen Production and bioengineering corneal endothelium
NHMRC Idea Grant 2020 - CIA; $470,000
NSW Medical Device Fund 2018 - Scientific Lead; $1.15Mil
(Fudan University; Shanghai EHT hospital) Serving as an international expert advisor for research projects | |
(Shanghai JiaoTong University) Collaboration on applying machine learning on health | |
(Saarland University Medical Center, Department of Ophthalmology) Machine learning, keratoconus research collaboration | |
(The University of Auckland) ANZ Corneal Bioengineering Working Group | |
(College of Applied Medical Sciences, Qassim University) Collaboration on using machine learning to monitor keratoconus progress | |
(Schepens Eye Research Institute of Mass Eye and Ear Department of Ophthalmology, Harvard Medical School) Research Collaboration Global Development Award 2022 |
Publications
Book Chapters
- You, J., Cozzi, P., Fitzgerald, A., Walsh, B., Russell, P., Willcox, M., Graham, P., Li, Y. (2012). Prostate cancer biomarkers and the emerging proteomic techniques used in biomarker research. In Hiroto S Watanabe (Eds.), Horizons in Cancer Research : Volume 47, (pp. 1-36). New York: Nova Science Publishers.
Journals
- Maher, C., Chen, Z., Zhou, Y., You, J., Sutton, G., Wallace, G. (2024). Innervation in corneal bioengineering. Acta Biomaterialia. [More Information]
- Song, Y., Hua, S., Sayyar, S., Chen, Z., Chung, J., Liu, X., Yue, Z., Angus, C., Filippi, B., Beirne, S., Sutton, G., You, J., et al (2022). Corneal bioprinting using a high concentration pure collagen I transparent bioink. Bioprinting, 28. [More Information]
- You, J., Frazer, H., Sayyar, S., Chen, Z., Liu, X., Taylor, A., Filippi, B., Beirne, S., Wise, I., Petsoglou, C., Hodge, C., Sutton, G., et al (2022). Development of an In Situ Printing System With Human Platelet Lysate-Based Bio-Adhesive to Treat Corneal Perforations. Translational Vision Science and Technology, 11(6). [More Information]
Conferences
- Hallett, N., Yi, K., Dick, J., Hodge, C., Sutton, G., Wang, Y., You, J. (2020). Deep Learning Based Unsupervised and Semi-supervised Classification for Keratoconus. 2020 International Joint Conference on Neural Networks (IJCNN), Piscataway: Institute of Electrical and Electronics Engineers (IEEE). [More Information]
2024
- Maher, C., Chen, Z., Zhou, Y., You, J., Sutton, G., Wallace, G. (2024). Innervation in corneal bioengineering. Acta Biomaterialia. [More Information]
2022
- Song, Y., Hua, S., Sayyar, S., Chen, Z., Chung, J., Liu, X., Yue, Z., Angus, C., Filippi, B., Beirne, S., Sutton, G., You, J., et al (2022). Corneal bioprinting using a high concentration pure collagen I transparent bioink. Bioprinting, 28. [More Information]
- You, J., Frazer, H., Sayyar, S., Chen, Z., Liu, X., Taylor, A., Filippi, B., Beirne, S., Wise, I., Petsoglou, C., Hodge, C., Sutton, G., et al (2022). Development of an In Situ Printing System With Human Platelet Lysate-Based Bio-Adhesive to Treat Corneal Perforations. Translational Vision Science and Technology, 11(6). [More Information]
- Meganathan, I., Pachaiyappan, M., Aarthy, M., Radhakrishnan, J., Mukherjee, S., Shanmugam, G., You, J., Ayyadurai, N. (2022). Recombinant and genetic code expanded collagen-like protein as a tailorable biomaterial. Materials Horizons, 9(11), 2698-2721. [More Information]
2021
- Song, Y., Overmass, M., Fan, J., Hodge, C., Sutton, G., Lovicu, F., You, J. (2021). Application of Collagen I and IV in Bioengineering Transparent Ocular Tissues. Frontiers in Surgery, 8, 639500. [More Information]
- Petsoglou, C., Wen, L., Hoque, M., Zhu, M., Valtink, M., Sutton, G., You, J. (2021). Effects of human platelet lysate on the growth of cultured human corneal endothelial cells. Experimental Eye Research, 208, 108613. [More Information]
2020
- Chen, Z., Liu, X., You, J., Song, Y., Tomaskovic-Crook, E., Sutton, G., Crook, J., Wallace, G. (2020). Biomimetic corneal stroma using electro-compacted collagen. Acta Biomaterialia, 113, 360-371. [More Information]
- Hallett, N., Yi, K., Dick, J., Hodge, C., Sutton, G., Wang, Y., You, J. (2020). Deep Learning Based Unsupervised and Semi-supervised Classification for Keratoconus. 2020 International Joint Conference on Neural Networks (IJCNN), Piscataway: Institute of Electrical and Electronics Engineers (IEEE). [More Information]
- Frazer, H., You, J., Chen, Z., Sayyar, S., Liu, X., Taylor, A., Hodge, C., Wallace, G., Sutton, G. (2020). Development of a platelet lysate–based printable, transparent biomaterial with regenerative potential for epithelial corneal injuries. Translational Vision Science and Technology, 9(13), 1-12. [More Information]
2018
- Chen, Z., You, J., Cooper, S., Hodge, C., Sutton, G., Crook, J., Wallace, G. (2018). Biomaterials for corneal bioengineering. Biomedical Materials, 13(3), 32002. [More Information]
- You, J., Munoz-Erazo, L., Wen, L., Hodge, C., Madigan, M., Sutton, G. (2018). In-Vitro Effects of Secreted Frizzled-Related Protein 1 (SFRP1) On Human Corneal Epithelial Cells. Current Eye Research, 43(4), 455-459. [More Information]
- You, J., Corley, S., Wen, L., Hodge, C., Hollhumer, R., Madigan, M., Wilkins, M., Sutton, G. (2018). RNA-Seq analysis and comparison of corneal epithelium in keratoconus and myopia patients. Scientific Reports, 8(1), 1-13. [More Information]
2017
- Markoulli, M., You, J., Kim, J., Duong, C., Tolentino, J., Karras, J., Lum, E. (2017). Corneal Nerve Morphology and Tear Film Substance P in Diabetes. Optometry and Vision Science, 94(7), 726-731. [More Information]
- Golebiowski, B., Badarudin, N., Eden, J., You, J., Hampel, U., Stapleton, F. (2017). Does endogenous serum oestrogen play a role in meibomian gland dysfunction in postmenopausal women with dry eye? The British Journal of Ophthalmology, 101(2), 218-222. [More Information]
- Pinheiro, L., O'Brien, H., Druce, J., Do, H., Kay, P., Daniels, M., You, J., Burke, D., Griffiths, K., Emslie, K. (2017). Interlaboratory Reproducibility of Droplet Digital Polymerase Chain Reaction Using a New DNA Reference Material Format. Analytical Chemistry, 89(21), 11243-11251. [More Information]
2016
- You, J., Willcox, M., Fitzgerald, A., Schiller, B., Cozzi, P., Russell, P., Walsh, B., Wasinger, V., Graham, P., Li, Y. (2016). Absolute quantification of human tear lactoferrin using multiple reaction monitoring technique with stable-isotopic labeling. Analytical Biochemistry, 496, 30-34. [More Information]
2015
- You, J., Wen, L., Roufas, A., Hodge, C., Sutton, G., Madigan, M. (2015). Expression of HGF and c-Met Proteins in Human Keratoconus Corneas. Journal of Ophthalmology, 2015 (Article number 852986), 1-9. [More Information]
2014
- Wen, L., Zhu, M., Madigan, M., You, J., King, N., Billson, F., McClellan, K., Sutton, G., Petsoglou, C. (2014). Immunomodulatory Effects of Bone Marrow-Derived Mesenchymal Stem Cells on Pro-Inflammatory Cytokine- Stimulated Human Corneal Epithelial Cells. PloS One, 9(7), 1-12. [More Information]
2013
- You, J., Wen, L., Roufas, A., Madigan, M., Sutton, G. (2013). Expression of SFRP Family Proteins in Human Keratoconus Corneas. PloS One, 8(6), 1-11. [More Information]
- You, J., Wilcox, M., Madigan, M., Wasinger, V., Schiller, B., Walsh, B., Graham, P., Kearsley, J., Li, Y. (2013). Tear Fluid Protein Biomarkers. Advances in Clinical Chemistry, 62, 151-196. [More Information]
- You, J., Hodge, C., Wen, L., McAvoy, J., Madigan, M., Sutton, G. (2013). Tear levels of SFRP1 are significantly reduced in keratoconus patients. Molecular Vision, 19, 509-515. [More Information]
2012
- You, J., Madigan, M., Rowe, A., Sajinovic, M., Russell, P., Jackson, P. (2012). An inverse relationship between KAI1 expression, invasive ability, and MMP-2 expression and activity in bladder cancer cell lines. Urologic Oncology: Seminars and Original Investigations, 30(4), 502-538. [More Information]
- You, J., Cozzi, P., Fitzgerald, A., Walsh, B., Russell, P., Willcox, M., Graham, P., Li, Y. (2012). Prostate cancer biomarkers and the emerging proteomic techniques used in biomarker research. In Hiroto S Watanabe (Eds.), Horizons in Cancer Research : Volume 47, (pp. 1-36). New York: Nova Science Publishers.
- Madigan, M., You, J., Wen, L., Hodge, C., Roufas, A., McAvoy, J., Sutton, G. (2012). Secreted frizzled proteins in control and keratoconus (KC) tears and corneas. Acta Ophthalmologica, 90(Supplement s249). [More Information]
Selected Grants
2024
- FMH Start-up Scheme, You J, Faculty of Medicine and Health/New Academic Staff Funding
- Collagen based biomedical research to develop new treatment in health and new technology in biomanufacturing, You J, DVC Research/Sydney Horizon Fellowship
2023
- Australian Corneal Bioengineering: Novel Therapies to Fight Blindness (BIENCO), Sutton G, You J, Hua S, Department of Health and Aged Care (Federal)/MRFF 2021 Frontier Health and Medical Research Grant Opportunity
- Collagen Bioglue for Retinal Detachment Repair, Simunovic M, You J, Fan J, The Macula Society/International Retinal Research Foundation Award
Patents:
1. Collagen Gel Formulations, 2021, WO, US, CN, AU WO2021097524A1
2. Bioengineered Endothelial Constructs, 2022, AU WO WO2022192967A1
3. Collagen IV Bioinks, 2022, AU WO WO20192966A1
4. Platelet lysate compositions and uses thereof, 2019, WO, EP, US, CN, JP, AU WO2020028944A1
5. Collagen compositions and uses thereof, 2023, AU2023903431A0
In the media
ISER YI Seminar Series 1: International Transitions
https://www.youtube.com/watch?v=JJd8PML8HQ0&t=10s
Spark Festival 2020 - commercialisation and research interview
https://www.youtube.com/watch?v=hNl5kpQKoUQ
DHIN 2020
https://dhin.net.au/five-minutes-with-dr-jingjing-you/
Insight 2019
https://www.insightnews.com.au/first-vaegan-seminar-for-2019/
Medical device fund recipients 2018 - iFix Medical
https://www.youtube.com/watch?v=OdFgKG4FU-E&t=269s