Dr Jingjing You
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Dr Jingjing You

Group Lead
Sydney Horizon Fellow
School of Medical Sciences and Save Sight Institute
Faculty of Medicine and Health
Dr Jingjing You

Jingjing You, PhD, GradCert RSCH MNGT&COMMERCIAL

Senior Lecturer in Biomedicine | Lead Tutor, Pathogenesis R.P. Cell Pathology

Head of Innovative Biomedicine Research Group

School of Medical Sciences and Save Sight Institute, University of Sydney

Other Affiliations:

Visiting Academic, School of Optometry and Vision Science, UNSW, Sydney

External Scientific Advisor, NSW Tissue Bank

Chief Scientific Advisor, iFix Medical Pty Ltd

3D bioprinting; biomaterial development; tissue engineering; advance manufacturing; machine learning; collagen; regenerative medicine, wound healing

Tissue engineering

Biomaterial

Matrix protein and cell interation

Eye Research

Machine learning

Light related clinical applications

Master/ PhD

1. Investigating the role of collagen in healthy and diseased tissues

2. Reconstruction of eye tissues using tissue engineering approach

3. Development of a sensitive platform for tear protein detction

4. Machine learning in diagnosing and monitoring diseases

5. Advance manufacturing on novel biomaterials

International Society of Eye Research

Tear Film and Ocular Surface Society

Digital Health and Informatics Network (DHIN)

ANZ Bioengineering Cornea Working Group - Founder

BIENCO (BioEngineeringCornea) - Founder

Major Funding awarded:

MRFF Frontier and Health 2023; $35Mil; CI-Project Lead for Collagen Production and bioengineering corneal endothelium

MRFF Frontier and Health 2021; near $1Mil- Stage 1CI-Project Lead for Collagen Production and bioengineering corneal endothelium

NHMRC Idea Grant 2020 - CIA; $470,000

NSW Medical Device Fund 2018 - Scientific Lead; $1.15Mil

Infection and Immunological Conditions, Neurosciences and Mental Health
Project titleResearch student
Developing the collagen-based application for corneal diseasesYuan FANG
Stem cell-derived corneal endothelial cell differentiationAlex LIN

Publications

Book Chapters

  • You, J., Cozzi, P., Fitzgerald, A., Walsh, B., Russell, P., Willcox, M., Graham, P., Li, Y. (2012). Prostate cancer biomarkers and the emerging proteomic techniques used in biomarker research. In Hiroto S Watanabe (Eds.), Horizons in Cancer Research : Volume 47, (pp. 1-36). New York: Nova Science Publishers.

Journals

  • Maher, C., Chen, Z., Zhou, Y., You, J., Sutton, G., Wallace, G. (2024). Innervation in corneal bioengineering. Acta Biomaterialia. [More Information]
  • Song, Y., Hua, S., Sayyar, S., Chen, Z., Chung, J., Liu, X., Yue, Z., Angus, C., Filippi, B., Beirne, S., Sutton, G., You, J., et al (2022). Corneal bioprinting using a high concentration pure collagen I transparent bioink. Bioprinting, 28. [More Information]
  • You, J., Frazer, H., Sayyar, S., Chen, Z., Liu, X., Taylor, A., Filippi, B., Beirne, S., Wise, I., Petsoglou, C., Hodge, C., Sutton, G., et al (2022). Development of an In Situ Printing System With Human Platelet Lysate-Based Bio-Adhesive to Treat Corneal Perforations. Translational Vision Science and Technology, 11(6). [More Information]

Conferences

  • Hallett, N., Yi, K., Dick, J., Hodge, C., Sutton, G., Wang, Y., You, J. (2020). Deep Learning Based Unsupervised and Semi-supervised Classification for Keratoconus. 2020 International Joint Conference on Neural Networks (IJCNN), Piscataway: Institute of Electrical and Electronics Engineers (IEEE). [More Information]

2024

  • Maher, C., Chen, Z., Zhou, Y., You, J., Sutton, G., Wallace, G. (2024). Innervation in corneal bioengineering. Acta Biomaterialia. [More Information]

2022

  • Song, Y., Hua, S., Sayyar, S., Chen, Z., Chung, J., Liu, X., Yue, Z., Angus, C., Filippi, B., Beirne, S., Sutton, G., You, J., et al (2022). Corneal bioprinting using a high concentration pure collagen I transparent bioink. Bioprinting, 28. [More Information]
  • You, J., Frazer, H., Sayyar, S., Chen, Z., Liu, X., Taylor, A., Filippi, B., Beirne, S., Wise, I., Petsoglou, C., Hodge, C., Sutton, G., et al (2022). Development of an In Situ Printing System With Human Platelet Lysate-Based Bio-Adhesive to Treat Corneal Perforations. Translational Vision Science and Technology, 11(6). [More Information]
  • Meganathan, I., Pachaiyappan, M., Aarthy, M., Radhakrishnan, J., Mukherjee, S., Shanmugam, G., You, J., Ayyadurai, N. (2022). Recombinant and genetic code expanded collagen-like protein as a tailorable biomaterial. Materials Horizons, 9(11), 2698-2721. [More Information]

2021

  • Song, Y., Overmass, M., Fan, J., Hodge, C., Sutton, G., Lovicu, F., You, J. (2021). Application of Collagen I and IV in Bioengineering Transparent Ocular Tissues. Frontiers in Surgery, 8, 639500. [More Information]
  • Petsoglou, C., Wen, L., Hoque, M., Zhu, M., Valtink, M., Sutton, G., You, J. (2021). Effects of human platelet lysate on the growth of cultured human corneal endothelial cells. Experimental Eye Research, 208, 108613. [More Information]

2020

  • Chen, Z., Liu, X., You, J., Song, Y., Tomaskovic-Crook, E., Sutton, G., Crook, J., Wallace, G. (2020). Biomimetic corneal stroma using electro-compacted collagen. Acta Biomaterialia, 113, 360-371. [More Information]
  • Hallett, N., Yi, K., Dick, J., Hodge, C., Sutton, G., Wang, Y., You, J. (2020). Deep Learning Based Unsupervised and Semi-supervised Classification for Keratoconus. 2020 International Joint Conference on Neural Networks (IJCNN), Piscataway: Institute of Electrical and Electronics Engineers (IEEE). [More Information]
  • Frazer, H., You, J., Chen, Z., Sayyar, S., Liu, X., Taylor, A., Hodge, C., Wallace, G., Sutton, G. (2020). Development of a platelet lysate–based printable, transparent biomaterial with regenerative potential for epithelial corneal injuries. Translational Vision Science and Technology, 9(13), 1-12. [More Information]

2018

  • Chen, Z., You, J., Cooper, S., Hodge, C., Sutton, G., Crook, J., Wallace, G. (2018). Biomaterials for corneal bioengineering. Biomedical Materials, 13(3), 32002. [More Information]
  • You, J., Munoz-Erazo, L., Wen, L., Hodge, C., Madigan, M., Sutton, G. (2018). In-Vitro Effects of Secreted Frizzled-Related Protein 1 (SFRP1) On Human Corneal Epithelial Cells. Current Eye Research, 43(4), 455-459. [More Information]
  • You, J., Corley, S., Wen, L., Hodge, C., Hollhumer, R., Madigan, M., Wilkins, M., Sutton, G. (2018). RNA-Seq analysis and comparison of corneal epithelium in keratoconus and myopia patients. Scientific Reports, 8(1), 1-13. [More Information]

2017

  • Markoulli, M., You, J., Kim, J., Duong, C., Tolentino, J., Karras, J., Lum, E. (2017). Corneal Nerve Morphology and Tear Film Substance P in Diabetes. Optometry and Vision Science, 94(7), 726-731. [More Information]
  • Golebiowski, B., Badarudin, N., Eden, J., You, J., Hampel, U., Stapleton, F. (2017). Does endogenous serum oestrogen play a role in meibomian gland dysfunction in postmenopausal women with dry eye? The British Journal of Ophthalmology, 101(2), 218-222. [More Information]
  • Pinheiro, L., O'Brien, H., Druce, J., Do, H., Kay, P., Daniels, M., You, J., Burke, D., Griffiths, K., Emslie, K. (2017). Interlaboratory Reproducibility of Droplet Digital Polymerase Chain Reaction Using a New DNA Reference Material Format. Analytical Chemistry, 89(21), 11243-11251. [More Information]

2016

  • You, J., Willcox, M., Fitzgerald, A., Schiller, B., Cozzi, P., Russell, P., Walsh, B., Wasinger, V., Graham, P., Li, Y. (2016). Absolute quantification of human tear lactoferrin using multiple reaction monitoring technique with stable-isotopic labeling. Analytical Biochemistry, 496, 30-34. [More Information]

2015

  • You, J., Wen, L., Roufas, A., Hodge, C., Sutton, G., Madigan, M. (2015). Expression of HGF and c-Met Proteins in Human Keratoconus Corneas. Journal of Ophthalmology, 2015 (Article number 852986), 1-9. [More Information]

2014

  • Wen, L., Zhu, M., Madigan, M., You, J., King, N., Billson, F., McClellan, K., Sutton, G., Petsoglou, C. (2014). Immunomodulatory Effects of Bone Marrow-Derived Mesenchymal Stem Cells on Pro-Inflammatory Cytokine- Stimulated Human Corneal Epithelial Cells. PloS One, 9(7), 1-12. [More Information]

2013

  • You, J., Wen, L., Roufas, A., Madigan, M., Sutton, G. (2013). Expression of SFRP Family Proteins in Human Keratoconus Corneas. PloS One, 8(6), 1-11. [More Information]
  • You, J., Wilcox, M., Madigan, M., Wasinger, V., Schiller, B., Walsh, B., Graham, P., Kearsley, J., Li, Y. (2013). Tear Fluid Protein Biomarkers. Advances in Clinical Chemistry, 62, 151-196. [More Information]
  • You, J., Hodge, C., Wen, L., McAvoy, J., Madigan, M., Sutton, G. (2013). Tear levels of SFRP1 are significantly reduced in keratoconus patients. Molecular Vision, 19, 509-515. [More Information]

2012

  • You, J., Madigan, M., Rowe, A., Sajinovic, M., Russell, P., Jackson, P. (2012). An inverse relationship between KAI1 expression, invasive ability, and MMP-2 expression and activity in bladder cancer cell lines. Urologic Oncology: Seminars and Original Investigations, 30(4), 502-538. [More Information]
  • You, J., Cozzi, P., Fitzgerald, A., Walsh, B., Russell, P., Willcox, M., Graham, P., Li, Y. (2012). Prostate cancer biomarkers and the emerging proteomic techniques used in biomarker research. In Hiroto S Watanabe (Eds.), Horizons in Cancer Research : Volume 47, (pp. 1-36). New York: Nova Science Publishers.
  • Madigan, M., You, J., Wen, L., Hodge, C., Roufas, A., McAvoy, J., Sutton, G. (2012). Secreted frizzled proteins in control and keratoconus (KC) tears and corneas. Acta Ophthalmologica, 90(Supplement s249). [More Information]

Selected Grants

2024

  • FMH Start-up Scheme, You J, Faculty of Medicine and Health/New Academic Staff Funding
  • Collagen based biomedical research to develop new treatment in health and new technology in biomanufacturing, You J, DVC Research/Sydney Horizon Fellowship

2023

  • Australian Corneal Bioengineering: Novel Therapies to Fight Blindness (BIENCO), Sutton G, You J, Hua S, Department of Health and Aged Care (Federal)/MRFF 2021 Frontier Health and Medical Research Grant Opportunity
  • Collagen Bioglue for Retinal Detachment Repair, Simunovic M, You J, Fan J, The Macula Society/International Retinal Research Foundation Award

Patents:

1. Collagen Gel Formulations, 2021, WO, US, CN, AU WO2021097524A1

2. Bioengineered Endothelial Constructs, 2022, AU WO WO2022192967A1

3. Collagen IV Bioinks, 2022, AU WO WO20192966A1

4. Platelet lysate compositions and uses thereof, 2019, WO, EP, US, CN, JP, AU WO2020028944A1

5. Collagen compositions and uses thereof, 2023, AU2023903431A0

In the media

ISER YI Seminar Series 1: International Transitions

https://www.youtube.com/watch?v=JJd8PML8HQ0&t=10s

Spark Festival 2020 - commercialisation and research interview

https://www.youtube.com/watch?v=hNl5kpQKoUQ

DHIN 2020

https://dhin.net.au/five-minutes-with-dr-jingjing-you/

Insight 2019

https://www.insightnews.com.au/first-vaegan-seminar-for-2019/

Medical device fund recipients 2018 - iFix Medical

https://www.youtube.com/watch?v=OdFgKG4FU-E&t=269s