Associate Professor Michael Buckland
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Associate Professor Michael Buckland

Clinical Associate Professor
Pathology, School of Medical Sciences
Phone
+61 2 9114 4009
Fax
+61 2 9114 4020
Associate Professor Michael Buckland

Michael Buckland is a Senior Staff Specialist and the Head of the Department of Neuropathology at Royal Prince Alfred Hospital. He is the founder and Director of the Australian Sports Brain Bank, Co-Director of theMultiple Sclerosis Australia Brain Bank, andHead of the Molecular Neuropathology Program at the Brain & Mind Centre. He is also a key partner in Brainstorm.

Chronic Traumatic Encephalopathy

Gliomas

Epigenetics

Neuroinflammatory diseases

Neurodegenerative diseases

Obesity, Diabetes and Cardiovascular Disease, Cancer, Neurosciences and Mental Health

Publications

Journals

  • Marinelli, T., Masters, J., Buckland, M., Lee, M., Rawlinson, W., Kim, K., Urriola, N., van Hal, S. (2024). Chronic and Neurotropic: A Paradigm-Challenging Case of Dengue Virus Encephalitis in a Patient with Advanced HIV Infection. Clinical Infectious Diseases, 79(2), 498-501. [More Information]
  • Satgunaseelan, L., Sy, J., Shivalingam, B., Sim, H., Alexander, K., Buckland, M. (2024). Prognostic and predictive biomarkers in central nervous system tumours: the molecular state of play. Pathology. [More Information]
  • Lasocki, A., Buckland, M., Molinaro, T., Xie, J., Whittle, J., Wei, H., Gaillard, F. (2023). Correlating MRI features with additional genetic markers and patient survival in histological grade 2-3 IDH-mutant astrocytomas. Neuroradiology, 65(8), 1215-1223. [More Information]

Conferences

  • Jelinek, H., Ahammer, H., Matthews, S., Succar, P., McLachlan, C., Buckland, M. (2012). Establishing a reference range for oligodendroglioma classification using Higuchi dimension analysis. 9th IASTED International Conference on Biomedical Engineering (BioMed 2012), Innsbruck: ACTA Press. [More Information]

2024

  • Marinelli, T., Masters, J., Buckland, M., Lee, M., Rawlinson, W., Kim, K., Urriola, N., van Hal, S. (2024). Chronic and Neurotropic: A Paradigm-Challenging Case of Dengue Virus Encephalitis in a Patient with Advanced HIV Infection. Clinical Infectious Diseases, 79(2), 498-501. [More Information]
  • Satgunaseelan, L., Sy, J., Shivalingam, B., Sim, H., Alexander, K., Buckland, M. (2024). Prognostic and predictive biomarkers in central nervous system tumours: the molecular state of play. Pathology. [More Information]

2023

  • Lasocki, A., Buckland, M., Molinaro, T., Xie, J., Whittle, J., Wei, H., Gaillard, F. (2023). Correlating MRI features with additional genetic markers and patient survival in histological grade 2-3 IDH-mutant astrocytomas. Neuroradiology, 65(8), 1215-1223. [More Information]
  • Pamphlett, R., Buckland, M., Bishop, D. (2023). Potentially toxic elements in the brains of people with multiple sclerosis. Scientific Reports, 13(1). [More Information]
  • Tuzusi, A., Hallal, S., Satgunaseelan, L., Buckland, M., Alexander, K. (2023). Understanding the Epitranscriptome for Avant-Garde Brain Tumour Diagnostics. Cancers, 15(4). [More Information]

2022

  • Alzoubi, I., Bao, G., Zhang, R., Loh, C., Zheng, Y., Cherepanoff, S., Gracie, G., Lee, M., Kuligowski, M., Alexander, K., Buckland, M., Wang, X., Graeber, M. (2022). An Open-Source AI Framework for the Analysis of Single Cells in Whole-Slide Images with a Note on CD276 in Glioblastoma. Cancers, 14(14). [More Information]
  • Nowinski, C., Bureau, S., Buckland, M., Curtis, M., Daneshvar, D., Faull, R., Grinberg, L., Hill-Yardin, E., Murray, H., Pearce, A., Suter, C., et al (2022). Applying the Bradford Hill Criteria for Causation to Repetitive Head Impacts and Chronic Traumatic Encephalopathy. Frontiers in Neurology, 13. [More Information]
  • Valenzuela, M., Duncan, T., Abey, A., Johnson, A., Boulamatsis, C., Dalton, M., Jacobson, E., Brunel, L., Child, G., Simpson, D., Buckland, M., et al (2022). Autologous skin-derived neural precursor cell therapy reverses canine Alzheimer dementia-like syndrome in a proof of concept veterinary trial. Stem Cell Research & Therapy, 13, 261-1-261-20. [More Information]

2021

  • Goire, N., Buckland, M., Cuganesan, R., Saleem, S., Lea, V., Beran, R. (2021). A diagnostic dilemma of white matter lesions and cerebral oedema without identifiable cause—A neurological conundrum. Brain Sciences, 11(9), 1238. [More Information]
  • Sim, H., McDonald, K., Lwin, Z., Barnes, E., Rosenthal, M., Foote, M., Koh, E., Back, M., Wheeler, H., Sulman, E., Buckland, M., Fisher, L., Leonard, R., Hall, M., Yip, S., Simes, R., Khasraw, M., et al (2021). A randomized phase II trial of veliparib, radiotherapy, and temozolomide in patients with unmethylated MGMT glioblastoma: The VERTU study. Neuro-Oncology, 23(10), 1736-1749. [More Information]
  • Pearce, A., Kidgell, D., Tommerdahl, M., Frazer, A., Rist, B., Mobbs, R., Batchelor, J., Buckland, M. (2021). Chronic Neurophysiological Effects of Repeated Head Trauma in Retired Australian Male Sport Athletes. Frontiers in Neurology, 12, 633320. [More Information]

2020

  • Hallal, S., Azimi, A., Wei, G., Ho, N., Lee, M., Sim, H., Sy, J., Shivalingam, B., Buckland, M., Alexander, K. (2020). A comprehensive proteomic SWATH-MS workflow for profiling blood extracellular vesicles: A new avenue for glioma tumour surveillance. International Journal of Molecular Sciences, 21(13), 1-26. [More Information]
  • De Sousa, S., Toubia, J., Hardy, T., Feng, J., Wang, P., Schreiber, A., Geoghegan, J., Hall, R., Rawlings, L., Buckland, M., et al (2020). Aberrant splicing of SDHC in families with unexplained succinate dehydrogenase-deficient paragangliomas. Journal of the Endocrine Society, 4(12). [More Information]
  • Itchins, M., Lau, B., Hudson, A., Westman, H., Xia, C., Hayes, S., Howell, V., Rodriguez, M., Cooper, W., Wei, G., Buckland, M., Li, B., Gill, A., Clarke, S., Pavlakis, N., et al (2020). ALK-Rearranged Non-Small Cell Lung Cancer in 2020: Real-World Triumphs in an Era of Multigeneration ALK-Inhibitor Sequencing Informed by Drug Resistance Profiling. The Oncologist, 25(8), 641-649. [More Information]

2019

  • Gross, C., Meyer, C., Bhatia, U., Yshii, L., Kleffner, I., Bauer, J., Troscher, A., Schulte-Mecklenbeck, A., Herich, S., Schneider-Hohendorf, T., Parratt, J., Barnett, M., Buckland, M., Hardy, T., Reddel, S., Wiendl, H., et al (2019). CD8+ T cell-mediated endotheliopathy is a targetable mechanism of neuro-inflammation in Susac syndrome. Nature Communications, 10(1), 1-19. [More Information]
  • Buckland, M., Sy, J., Lee, M., Halliday, G., Szentmariay, I., Kullen, A., Harding, A., Suter, C. (2019). Chronic traumatic encephalopathy in two former Australian National Rugby League players. Acta Neuropathologica Communications, 7(1), 1-4. [More Information]
  • Gedye, C., Sachchithananthan, M., Leonard, R., Jeffree, R., Buckland, M., Ziegler, D., Graeber, M., Day, B., McDonald, K., Lasocki, A., Nowak, A. (2019). Driving innovation through collaboration: development of clinical annotation datasets for brain cancer biobanking. Neuro-Oncology Practice, 7(1), 31-37. [More Information]

2018

  • Kim, J., Kong, B., Lo, T., Papadimitrous, M., Hsu, J., Fromm, P., Alexander, K., Buckland, M., Clark, G., Hart, D. (2018). A combinatory immunotherapy against brain tumour: blood dendritic cell based vaccine therapy with checkpoint inhibitor(s). Neuro-Oncology, 20(Suppl 6), vi94-vi95. [More Information]
  • Lubomski, M., Buckland, M., Sy, J., Wei, G., Tan, I., Kane, B., Spring, P. (2018). Adult-onset leukoencephalopathy with neuroaxonal spheroids and pigmented glia mimicking systemic lupus erythematosus cerebral vasculitis. Journal of the Neurological Sciences, 395, 25-28. [More Information]
  • Ebrahimkhani, S., Vafaee, F., Hallal, S., Wei, H., Lee, M., Young, P., Satgunaseelan, L., Beadnall, H., Barnett, M., Shivalingam, B., Buckland, M., Alexander, K., et al (2018). Deep sequencing of circulating exosomal microRNA allows non-invasive glioblastoma diagnosis. n p j Precision Oncology, 2, 1-9. [More Information]

2017

  • van de Nes, J., Koelsche, C., Gessi, M., Moller, I., Sucker, A., Scolyer, R., Buckland, M., Pietsch, T., Murali, R., Schadendorf, D., et al (2017). Activating CYSLTR2 and PLCB4 Mutations in Primary Leptomeningeal Melanocytic Tumors. Journal of Investigative Dermatology, 137(9), 2033-2035. [More Information]
  • Mallawaaratchy, D., Hallal, S., Russell, B., Ly, L., Ebrahimkhani, S., Wei, G., Christopherson, R., Buckland, M., Alexander, K. (2017). Comprehensive proteome profiling of glioblastoma-derived extracellular vesicles identifies markers for more aggressive disease. Journal of Neuro-Oncology, 131(2), 233-244. [More Information]
  • Chami, B., Yeung, A., Buckland, M., Liu, H., Fong, G., Tao, K., Bao, B. (2017). CXCR3 plays a critical role for host protection against Salmonellosis. Scientific Reports, 7(1), 1-10. [More Information]

2016

  • Huda, S., Yearwood, J., Jelinek, H., Hassan, M., Fortino, G., Buckland, M. (2016). A Hybrid Feature Selection with Ensemble Classification for Imbalanced Healthcare Data: A Case Study for Brain Tumor Diagnosis. IEEE Access, 4, 9145-9154. [More Information]
  • Massey, J., Buckland, M., Barnett, Y., Sutton, I. (2016). Expanding the range of immunopathology in neuromyelitis optica spectrum disorder. BMJ Case Reports, 2016, 1-4. [More Information]
  • Jukes, A., Allan, R., Rawson, R., Buckland, M. (2016). Growth hormone secreting pituitary adenoma with admixed gangliocytoma and ganglioglioma. Journal of Clinical Neuroscience, 31, 202-204. [More Information]

2015

  • Hardy, T., Beadnall, H., Sutton, I., Mohamed, A., Buckland, M., Barnett, M. (2015). Balo's concentric sclerosis and tumefactive demyelination: A shared immunopathogenesis? Journal of the Neurological Sciences, 348(1-2), 279-281. [More Information]
  • Hardy, T., O’Brien, B., Gerbis, N., Barnett, M., Reddel, S., Brewer, J., Herkes, G., Silberstein, P., Garsia, R., Watson, J., Gupta, R., Parratt, J., et al (2015). Brain histopathology in three cases of Susac's syndrome: Implications for lesion pathogenesis and treatment. Journal of Neurology, Neurosurgery and Psychiatry, 86(5), 582-584. [More Information]
  • Ramanathan, S., Fung, V., Bielich, A., Masters, L., Russo, R., Buckland, M., Sarros, S., Klug, G., Collins, S., Reddel, S. (2015). Hyperekplexia as the presenting symptom of Creutzfeldt-Jakob disease. Neurology: Clinical Practice, 5(6), 498-501. [More Information]

2014

  • Gessi, M., van de Nes, J., Griewank, K., Barresi, V., Buckland, M., Kirfel, J., Caltabiano, R., Hammes, J., Lauriola, L., Pietsch, T., et al (2014). Absence of TERT promoter mutations in primary melanocytic tumours of the central nervous system. Neuropathology and Applied Neurobiology, 40(6), 794-797. [More Information]
  • Quinn, E., Merritt, T., Buckland, M., Tobin, S. (2014). An update on the epidemiology and key issues associated with the diagnosis and management of Creutzfeldt-Jakob disease cases in NSW. Public Health Research and Practice, 25(1), 1-8. [More Information]
  • Alexander, K., Ly, L., McKay, M., Mallawaaratchy, D., Mactier, S., Crossett, B., Molloy, M., Buckland, M., McDonald, K., Christopherson, R. (2014). Comprehensive proteomic profiling of bevacizumab-resistant glioblastoma multiforme. Neuro-Oncology, 16(Suppl 2), ii98-ii98.

2013

  • Parker, N., Correia, N., Crossley, B., Buckland, M., Howell, V., Wheeler, H. (2013). Correlation of MicroRNA 132 Up-regulation with an Unfavorable Clinical Outcome in Patients with Primary Glioblastoma Multiforme Treated with Radiotherapy Plus Concomitant and Adjuvant Temozolomide Chemotherapy. Translational Oncology, 6(6), 742-748. [More Information]
  • Gupta, R., Flanagan, S., Li, C., Lee, M., Shivalingham, B., Maleki, S., Wheeler, H., Buckland, M. (2013). Expanding the spectrum of IDH1 mutations in gliomas. Modern Pathology, 26(5), 619-625. [More Information]
  • Li, C., Eaton, S., Young, P., Lee, M., Shuttleworth, R., Humphreys, D., Grau, G., Combes, V., Bebawy, M., Gong, J., Buckland, M., et al (2013). Glioma microvesicles carry selectively packaged coding and non-coding RNAs which alter gene expression in recipient cells. RNA Biology, 10(8), 1333-1344. [More Information]

2012

  • Tan, K., Brewer, J., Rowe, D., Jenkins, B., Powers, J., Buckland, M. (2012). Adult onset leucodystrophy with neuroaxonal spheroids and pigmented glia (ALSP): report of a new kindred. Neuropathology and Applied Neurobiology, 38(1), 95-100. [More Information]
  • Buckland, M., Salim, A., Wilson, P., Cherukuri, R., McKenzie, S. (2012). An unusual association of calcifying pseudoneoplasm of the neuraxis with interhemispheric lipoma and agenesis of corpus callosum. Pathology, 44(7), 657-659. [More Information]
  • Matthews, S., Succar, P., Jelinek, H., McParland, B., Buckland, M., McLachlan, C. (2012). Diagnosis of oligodendroglioma: Molecular and classical histological assessment in the twenty-first century. Asia-Pacific Journal of Clinical Oncology, 8(3), 213-216. [More Information]

2011

  • Ahmed, R., Buckland, M., Davies, L., Halmagyi, G., Rogers, S., Oberste, M., Barnett, M. (2011). Enterovirus 71 meningoencephalitis complicating rituximab therapy. Journal of the Neurological Sciences, 305(1-2), 149-151. [More Information]
  • Chang, F., Berman, Y., Buckland, M., MacKinlay, N., McGlade, A., Collins, S., Ng, K. (2011). Genetic prion disease-associated myelodysplasia and SIADH in siblings. European Journal of Neurology, 18(12), e149-e150. [More Information]
  • Lee, L., Sevastos, J., Rainer, S., Buckland, M. (2011). Giant cell tubulitis and tubular basement membrane immune deposits. Pathology, 43(4), 383-386. [More Information]

2010

  • Li, D., Brennan, J., Buckland, M., Parkinson, J. (2010). Bronchogenic carcinoid metastasis to the intramedullary spinal cord. Journal of Clinical Neuroscience, 17(9), 1196-1198. [More Information]

2009

  • Sim, R., Leecy, T., Buckland, M., Fagan, P. (2009). Axonal numbers in the greater auricular nerve: is there enough to go round? Otology & Neurotology, 30(3), 398-401. [More Information]
  • Bobryshev,, Y., Tran, D., Killingsworth, M., Buckland, M., Lord,, R. (2009). Dendritic Cell-Associated Immune Inflammation of Cardiac Mucosa: A Possible Factor in the Formation of Barrett's Esophagus. Journal of Gastrointestinal Surgery, 13(3), 442-450. [More Information]
  • Bobryshev,, Y., Tran, D., Killingsworth, M., Buckland, M., Lord, R. (2009). Dendritic Cells in Barrett's Esophagus and Esophageal Adenocarcinoma. Journal of Gastrointestinal Surgery, 13(1), 44-53. [More Information]

2008

  • Ismail, A., Milliken, S., Buckland, M. (2008). Acute neutropenic diverticulitis: a case report. Pathology, 40(4), 423-5. [More Information]
  • Leecy, T., Buckland, M., Turner, J., Earls, P. (2008). The use of immunohistochemistry in the diagnosis of primary salivary duct carcinoma: three case reports. Pathology, 40(4), 434-7. [More Information]

2007

  • Newland, L., Walsh, A., Gilbert, D., Buckland, M. (2007). Selective internal radiation therapy: a case of SIR-Sphere associated duodenal ulceration. Pathology, 39(5), 526-528. [More Information]

2006

  • Buckland, M., Leahy, B., Lukeis, R., Suter, M., Turner, J., Morey, A. (2006). Molecular testing for paraffin embedded material. Pathology, 38(6), 602. [More Information]

Selected Grants

2022

  • Supporting Australian Brain Cancer Research with an integrated network of platforms, Jeffree R, Day B, Gedye C, Koh E, Leonard R, Sim H, Varikatt W, Hansen D, Cossio D, Harrup R, Gan H, Zalcberg J, Simes R, O'Brien T, Drummond K, Pinkham M, Ormsby R, Gomez G, Alexander K, Buckland M, Good N, Sachchithananthan M, Scott A, Whittle J, Gately L, Ziegler D, Vajdic C, Lipworth W, Dickinson J, Quinn L, Aitken J, Lwin Z, Hansford J, Yuile A, Agar M, Kichenadasse G, Truran D, Francois G, Chin W, Kong B, Gabriel J, Lee A, Turner C, Evans S, Ng W, Sullivan R, Pitson S, Nguyen A, Department of Health and Aged Care (Federal - administered by NHMRC)/2022 MRFF Australian Brain Cancer Research Infrastructure
  • Targeting TREM2 on microglia to modulate lipid metabolism and enhance remyelination in multiple sclerosis, Piccio L, Goldsbury C, Don A, Buckland M, Multiple Sclerosis Australia/Project Grant

2020

  • Role of TREM2 in myelin clearance in multiple sclerosis lesions, Buckland M, Piccio L, Trish Multiple Sclerosis Research Foundation/Incubator Grant

In the media

https://insightplus.mja.com.au/2022/13/concussion-in-sport-conflicts-of-interest-drive-scandal/

https://www.theguardian.com/sport/2022/feb/28/concussion-in-sport-cte-found-in-more-than-half-of-sportspeople-who-donated-brains

https://www.theguardian.com/sport/2022/mar/17/he-was-just-a-baby-cte-robbed-footy-player-of-his-brain-and-then-his-life

https://www.theguardian.com/sport/2021/apr/30/damage-found-after-late-aflw-player-jacinda-barclay-donates-brain-for-concussion-research

https://www.theage.com.au/sport/afl/cte-discovered-in-polly-farmer-s-brain-in-landmark-afl-first-20200226-p544oq.html

https://www.smh.com.au/sport/nrl/rugby-league-rocked-by-first-proof-of-former-players-with-cte-20190626-p521ng.html