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Associate Professor Andrew Hoy

BSc MSc UOW, PhD UNSW

Robinson Fellow
School of Medical Sciences
Charles Perkins Centre

Phone

02 9351 2514

[email protected]

Details

Member of The Drug Discovery Initiative

Member of the Charles Perkins Centre

Websites

PubMed

Lipid Met Lab Twitter

Biographical details

Dr Hoy is Head of the Lipid Metabolism Laboratory in the School of Medical Sciences. His lab is a member of the Charles Perkins Centre. He is a Visiting Scientist in the Cancer Division of the Garvan Institute of Medical Research.

Research interests

Research conducted by my laboratory is focused on the regulation of lipid metabolism, predominantly fatty acid storage and utilisation, and how this may be perturbed in chronic disease states such as cancer, obesity and insulin resistance. We welcome interest in undergraduate and postgraduate research training in our lab from highly motivated students.

The lab is a team member of a Movember Foundation and Prostate Cancer Foundation of Australia-funded program focused on Lipids & Prostate Cancer .

Current Laboratory Members:

Hannah Prsa - Research Assistant
Guanming Di - BSc Hons Student, co-supervised by A/Prof Thomas Grewal and Prof Liz New

Teaching and supervision

PHSI2X08 - Exercise Physiology. Metabolic Physiology, Cardiovascular and Respiratory Physiology, fatigue, training and environmental influences

PHSI3X12 - Metabolic Diseases. Includes obesity, insulin resistance, type 2 diabetes, altered cancer behaviour

Current projects

The Lipid Metabolism Laboratory has two major research themes:

CancerMetabolism

This these has two sub-themes:

1) Cell metabolism is highly complex and there is extensive interactions between pathways that use different nutrients such as glucose, lipids and amino acids. This theme is focused on understanding these interactions and how they support a) membrane lipid synthesis, and b) mitochondrial metabolism. This project uses a genetically diverse panel of cancer cells and other models to gain new insights into cancer cell metabolism.

2) Metabolic diseases such as obesity and insulin resistance are risk factors for some cancers and have been shown to influence cancer behaviour. Tumours are characterised by a dramatic shift in their metabolic phenotype, primarily towards non-oxidative metabolism and increased lipid synthesis. That said, the role of fatty acid metabolism in the sustained growth of cancer cells has yet to be fully elucidated. This theme focuses on cancer metabolism; specifically, how intermediary metabolism and cancer behaviour is altered in an obese microenvironment and identifying novel metabolic therapeutic targets.

Lipid Metabolism and Insulin Resistance

The accumulation of lipid in tissues responsible for regulating blood glucose levels, including skeletal muscle and liver, results in development of insulin resistance. The vast majority of fatty acids are stored in the lipid droplet as triacylglycerols. Hence, the lipid droplet is at the centre of intracellular lipid homeostasis. However, triacylglycerols are not mechanistically linked to the development of insulin resistance. Other lipid species that can arise from lipid processes that occur at the lipid droplet have been proposed to instigate insulin resistance. This theme aims to understand the role of the metabolic processes that occur at the lipid droplet that are altered with insulin resistance.

Themes

Obesity, Diabetes and Cardiovascular Disease, Cancer, Healthy Ageing

Keywords

Breast cancer, Diabetes, Lipid metabolism, Obesity & overweight, Prostate cancer

Approaches

Animal Models, Cellular/Molecular, Metabolism

International links

Belgium

(KU Leuven) Professor Johan Swinnen

United States

(University of California - Berkeley) Asst Professor James Olzmann

United States

(University of Rochester, NY) Professor Michael Welte

Publications

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Book Chapters

Dehairs, J., Quek, L., Hoy, A., Swinnen, J., et al (2023). Tracer Lipidomics. Mass Spectrometry for Lipidomics: Methods and Applications, (pp. 641-655). Weinheim, Germany: Wiley-V C H Verlag Gmbh. [More Information]

Journals

Scott, J., Quek, L., Hoy, A., Swinnen, J., Nassar, Z., Butler, L. (2024). Fatty acid elongation regulates mitochondrial β-oxidation and cell viability in prostate cancer by controlling malonyl-CoA levels. Biochemical and Biophysical Research Communications, 691, 149273-1-149273-7. [More Information]
Mah, C., Don, A., Mills, I., Swinnen, J., Lynn, D., Nassar, Z., Butler, L., Nguyen, A., Niijima, T., Helm, M., Quek, L., Hoy, A., et al (2024). Peroxisomal β-oxidation enzyme, DECR2, regulates lipid metabolism and promotes treatment resistance in advanced prostate cancer. British Journal of Cancer, 130, 741-754. [More Information]
Jose, J., Hoque, M., Engel, J., Beevi, S., Wahba, M., Georgieva, M., Murphy, K., Hughes, W., Cochran, B., Lu, A., Hoy, A., Grewal, T., et al (2022). Annexin A6 and NPC1 regulate LDL-inducible cell migration and distribution of focal adhesions. Scientific Reports, 12(1), 596. [More Information]
Zipinotti dos Santos, D., Santos Guimaraes, I., Hakeem-Sanni, M., Cochran, B., Rye, K., Grewal, T., Hoy, A., Rangel, L. (2022). Atorvastatin improves cisplatin sensitivity through modulation of cholesteryl ester homeostasis in breast cancer cells. Discover Oncology, 13(1). [More Information]
Mak, B., Lin, H., Kwan, E., Fettke, H., Tran, B., Davis, I., Mahon, K., Stockler, M., Briscoe, K., Marx, G., Hoy, A., Horvath, L., et al (2022). Combined impact of lipidomic and genetic aberrations on clinical outcomes in metastatic castration-resistant prostate cancer. BMC Medicine, 20(1), 112-1-112-14. [More Information]
Quek, L., van Geldermalsen, M., Guan, Y., Wahi, K., Mayoh, C., Balaban, S., Pang, A., Wang, Q., Cowley, M., Brown, K., Hoy, A., et al (2022). Glutamine addiction promotes glucose oxidation in triple-negative breast cancer. Oncogene, 41(34), 4066-4078. [More Information]
Nguyen, M., Jose, J., Wahba, M., Bernaus-Esqué, M., Hoy, A., Enrich, C., Rentero, C., Grewal, T. (2022). Linking Late Endosomal Cholesterol with Cancer Progression and Anticancer Drug Resistance. International Journal of Molecular Sciences, 23(13). [More Information]
Mak, B., Lin, H., Duong, T., Mahon, K., Joshua, A., Stockler, M., Gurney, H., Parnis, F., Zhang, A., Scheinberg, T., Hoy, A., Horvath, L., et al (2022). Modulation of Plasma Lipidomic Profiles in Metastatic Castration-Resistant Prostate Cancer by Simvastatin. Cancers, 14(19). [More Information]
Gillis, J., Hinneh, J., Ryan, N., Irani, S., Moldovan, M., Quek, L., Shrestha, R., Hanson, A., Xie, J., Hoy, A., et al (2021). A feedback loop between the 1 androgen receptor and 6-phosphogluoconate dehydrogenase (6PGD) drives prostate cancer growth: Cooperativity between 6PGD and AR drives prostate cancer growth. eLife, 10, e62592 - 1-e62592 - 27. [More Information]
Kwan, K., Burvenich, I., Centenera, M., Goh, Y., Rigopoulos, A., Dehairs, J., Swinnen, J., Raj, G., Hoy, A., Butler, L., et al (2021). Synthesis and fluorine-18 radiolabeling of a phospholipid as a PET imaging agent for prostate cancer. Nuclear Medicine and Biology, 93, 37-45. [More Information]
Nagarajan, S., Butler, L., Hoy, A. (2021). The diversity and breadth of cancer cell fatty acid metabolism. Cancer and Metabolism, 9(1), 2. [More Information]
Hoy, A., Nagarajan, S., Butler, L. (2021). Tumour fatty acid metabolism in the context of therapy resistance and obesity. Nature Reviews Cancer, 21(12), 753-766. [More Information]
Miladinovic, D., Cusick, T., Mahon, K., Haynes, A., Cortie, C., Meyer, B., Stricker, P., Wittert, G., Butler, L., Horvath, L., Hoy, A. (2020). Assessment of periprostatic and subcutaneous adipose tissue lipolysis and adipocyte size from men with localized prostate cancer. Cancers, 12(6), 1385. [More Information]
Nassar, Z., Mah, C., Centenera, M., Irani, S., Sadowski, M., Scott, J., Nguyen, E., Nagarajan, S., Moldovan, M., Lynn, D., Hoy, A., et al (2020). Fatty Acid Oxidation Is an Adaptive Survival Pathway Induced in Prostate Tumors by HSP90 Inhibition. Molecular Cancer Research, 18(10), 1500-1511. [More Information]
Nassar, Z., Mah, C., Dehairs, J., Burvenich, I., Irani, S., Centenera, M., Helm, M., Shrestha, R., Moldovan, M., Don, A., Horvath, L., Hoy, A., et al (2020). Human decr1 is an androgen-repressed survival factor that regulates pufa oxidation to protect prostate tumor cells from ferroptosis. eLife, 9, 1-34. [More Information]
Krycer, J., Quek, L., Francis, D., Zadoorian, A., Weiss, F., Cooke, K., Nelson, M., Diaz Vegas, A., Humphrey, S., Scalzo, R., Varney, B., Nagarajan, S., Hoy, A., Cooney, G., Fazakerley, D., James, D., et al (2020). Insulin signaling requires glucose to promote lipid anabolism in adipocytes. Journal of Biological Chemistry, 295(38), 13250-13266. [More Information]
Nerstedt, A., Kurhe, Y., Cansby, E., Caputo, M., Gao, L., Vorontsov, E., Ståhlman, M., Nuñez-Durán, E., Borén, J., Marschall, H., Hoy, A., et al (2020). Lipid Droplet-Associated Kinase STK25 Regulates Peroxisomal Activity and Metabolic Stress Response in Steatotic Liver. Journal of Lipid Research, 61(2), 178-191. [More Information]
Balaban, S., Nassar, Z., Zhang, A., Hosseini Beheshti, E., Centenera, M., Schreuder, M., Lin, H., Aishah, A., Varney, B., Liu-Fu, F., Lee, L., Nagarajan, S., Hardie, R., Raftopulos, N., Kakani, M., Holst, J., Horvath, L., Hoy, A., et al (2019). Extracellular Fatty Acids Are the Major Contributor to Lipid Synthesis in Prostate Cancer. Molecular Cancer Research, 17(4), 949-962. [More Information]
Nagarajan, S., Paul-Heng, M., Krycer, J., Fazakerley, D., Sharland, A., Hoy, A. (2019). Lipid and Glucose Metabolism in Hepatocyte Cell Lines and Primary Mouse Hepatocytes: A comprehensive resource for in vitro studies of hepatic metabolism. American Journal of Physiology - Endocrinology and Metabolism, 316(4), E578-E589. [More Information]
Cairns, R., Fischer, A., Blanco-Munoz, P., Alvarez-Guaita, A., Meneses-Salas, E., Egert, A., Buechler, C., Hoy, A., Heeren, J., Enrich, C., Grewal, T., et al (2018). Altered hepatic glucose homeostasis in AnxA6-KO mice fed a high-fat diet. PloS One, 13(8), 1-26. [More Information]
Balaban, S., Lee, L., Varney, B., Aishah, A., Gao, Q., Shearer, R., Saunders, D., Grewal, T., Hoy, A. (2018). Heterogeneity of fatty acid metabolism in breast cancer cells underlies differential sensitivity to palmitate-induced apoptosis. Molecular Oncology, 12(9), 1623-1638. [More Information]
Attane, C., Milhas, D., Hoy, A., Muller, C. (2018). Metabolic remodeling induced by adipocytes: a new Achille heels in invasive breast cancer? Current Medicinal Chemistry, 25, 1-15. [More Information]
Nassar, Z., Aref, A., Miladinovic, D., Mah, C., Raj, G., Hoy, A., Butler, L. (2018). Peri-prostatic adipose tissue: the metabolic microenvironment of prostate cancer. BJU International, 121(S3), 9-21. [More Information]
Aref, A., Vincent, A., O'Callaghan, M., Martin, S., Sutherland, P., Hoy, A., Butler, L., Wittert, G. (2018). The inverse relationship between prostate specific antigen (PSA) and obesity. Endocrine-Related Cancer, 25(11), 933-941. [More Information]
Lin, H., Mahon, K., Weir, J., Mundra, P., Spielman, C., Briscoe, K., Gurney, H., Mallesara, G., Marx, G., Stockler, M., Hoy, A., Horvath, L., et al (2017). A distinct plasma lipid signature associated with poor prognosis in castration-resistant prostate cancer. International Journal of Cancer, 141(10), 2112-2120. [More Information]
Balaban, S., Shearer, R., Lee, L., van Geldermalsen, M., Schreuder, M., Shtein, H., Cairns, R., Cooke, K., Fazakerley, D., Grewal, T., Holst, J., Hoy, A., et al (2017). Adipocyte lipolysis links obesity to breast cancer growth: adipocyte-derived fatty acids drive breast cancer cell proliferation and migration. Cancer and Metabolism, 5(1). [More Information]
Hoy, A., Balaban, S., Saunders, D. (2017). Adipocyte-Tumor Cell Metabolic Crosstalk in Breast Cancer. Trends in Molecular Medicine, 23(5), 381-392. [More Information]
Nagarajan, S., Brandon, A., McKenna, J., Shtein, H., Nguyen, T., Suryana, E., Poronnik, P., Cooney, G., Saunders, D., Hoy, A. (2017). Insulin and diet-induced changes in the ubiquitin-modified proteome of rat liver. PloS One, 12(3), 1-14. [More Information]
Hardie, R., van Dam, E., Cowley, M., Han, T., Balaban, S., Pajic, M., Pinese, M., Iconomou, M., Shearer, R., McKenna, J., Hoy, A., et al (2017). Mitochondrial mutations and metabolic adaptation in pancreatic cancer. Cancer and Metabolism, 5, 1-15. [More Information]
Cairns, R., Alvarez-Guaita, A., Martínez-Saludes, I., Wason, S., Hanh, J., Nagarajan, S., Hosseini Beheshti, E., Monastyrskaya, K., Hoy, A., Buechler, C., Grewal, T., et al (2017). Role of hepatic Annexin A6 in fatty acid-induced lipid droplet formation. Experimental Cell Research, 358(2), 397-410. [More Information]
Meier, E., Rein-Fischboeck, L., Pohl, R., Wanninger, J., Hoy, A., Grewal, T., Eisinger, K., Krautbauer, S., Liebisch, G., Weiss, T., et al (2016). Annexin A6 protein is downregulated in human hepatocellular carcinoma. Molecular and Cellular Biochemistry, 418(1-2), 81-90. [More Information]
Meex, R., Hoy, A., Mason, R., Martin, S., McGee, S., Bruce, C., Watt, M. (2015). ATGL-mediated triglyceride turnover and the regulation of mitochondrial capacity in skeletal muscle. American Journal of Physiology - Endocrinology and Metabolism, 308(11), E960-E970. [More Information]
Meex, R., Hoy, A., Morris, A., Brown, R., Lo, J., Burke, M., Goode, R., Kingwell, B., Kraakman, M., Febbraio, M., et al (2015). Fetuin B Is a Secreted Hepatocyte Factor Linking Steatosis to Impaired Glucose Metabolism. Cell Metabolism, 22(6), 1078-1089. [More Information]
Gao, Q., Hanh, J., Varadi, L., Cairns, R., Sjoestroem, H., Liao, V., Wood, P., Balaban, S., Ong, J., Lin, H., Lai, F., Hoy, A., Grewal, T., Groundwater, P., Hibbs, D. (2015). Identification of dual PPARÎ±/Î³ agonists and their effects on lipid metabolism. Bioorganic and Medicinal Chemistry, 23(24), 7676-7684. [More Information]
Balaban, S., Lee, L., Schreuder, M., Hoy, A. (2015). Obesity and cancer progression: Is there a role of fatty acid metabolism? BioMed Research International, 2015, 1-7. [More Information]
Wang, Q., Hardie, R., Hoy, A., van Geldermalsen, M., Gao, D., Fazli, L., Sadowski, M., Balaban, S., Schreuder, M., Nagarajah, R., Wong, J., Metierre, C., Pinello, N., Otte, N., Bailey, C., Ritchie, W., Rasko, J., Holst, J., et al (2015). Targeting ASCT2-Mediated Glutamine Uptake Blocks Prostate Cancer Growth and Tumour Development. Journal of Pathology, 236(3), 278-289. [More Information]
Kamili, A., Roslan, N., Frost, S., Cantrill, L., Wang, D., Austin, D., Bright, R., Groblewski, G., Straub, B., Hoy, A., Chen, Y., Byrne, J. (2015). TPD52 expression increases neutral lipid storage within cultured cells. Journal of Cell Science, 128(17), 3223-3238. [More Information]
Briggs, D., Lockie, S., Benzler, J., Wu, Q., Stark, R., Reichenbach, A., Hoy, A., Lemus, M., Coleman, H., Parkington, H., et al (2014). Evidence That Diet-Induced Hyperleptinemia, but Not Hypothalamic Gliosis, Causes Ghrelin Resistance in NPY/AgRP Neurons of Male Mice. Endocrinology, 155(7), 2411-2422. [More Information]
Abboud, M., Gordon-Thomson, C., Hoy, A., Balaban, S., Rybchyn, M., Cole, L., Su, Y., Brennan-Speranza, T., Fraser, D., Mason, R. (2014). Uptake of 25-Hydroxyvitamin D by muscle and fat cells. Journal of Steroid Biochemistry and Molecular Biology, 144(Part A), 232-236. [More Information]
Peoples, G., Hoy, A., Henry, R., McLennan, P. (2013). Autologous pump-perfused rat hind limb preparation for investigating muscle function and metabolism in vivo. Microcirculation, 20(6), 511-523. [More Information]
Boon, J., Hoy, A., Stark, R., Brown, R., Meex, R., Henstridge, D., Schenk, S., Meikle, P., Horowitz, J., Kingwell, B., et al (2013). Ceramides contained in LDL are elevated in type 2 diabetes and promote inflammation and skeletal muscle insulin resistance. Diabetes, 62(2), 401-410. [More Information]
Kim, M., Lee, K., Iseli, T., Hoy, A., George, J., Grewal, T., Roufogalis, B. (2013). Compound K modulates fatty acid-induced lipid droplet formation and expression of proteins involved in lipid metabolism in hepatocytes. Liver International, 33(10), 1583-1593. [More Information]
Bell-Anderson, K., Funnell, A., Williams, H., Jusoh, H., Scully, T., Lim, W., Burdach, J., Mak, K., Knights, A., Hoy, A., Nicholas, H., Salis (nee Sainsbury), A., et al (2013). Loss of Kruppel-Like Factor 3 (KLF3/BKLF) Leads to Upregulation of the Insulin-Sensitizing Factor Adipolin (FAM132A/CTRP12/C1qdc2). Diabetes, 62(8), 2728-2737. [More Information]
Watt, M., Hoy, A., Muoio, D., Coleman, R. (2012). Distinct roles of specific fatty acids in cellular processes: implications for interpreting and reporting experiments. American Journal of Physiology - Endocrinology and Metabolism, 302(1), E1-E3. [More Information]
Watt, M., Hoy, A. (2012). Lipid metabolism in skeletal muscle: generation of adaptive and maladaptive intracellular signals for cellular function. American Journal of Physiology - Endocrinology and Metabolism, 302(11), e1315-e1328. [More Information]
Watt, M., Barnett, A., Bruce, C., Schenk, S., Horowitz, J., Hoy, A. (2012). Regulation of plasma ceramide levels with fatty acid oversupply: evidence that the liver detects and secretes de novo synthesised ceramide. Diabetologia, 55(10), 2741-2746. [More Information]
Turpin, S., Hoy, A., Brown, R., Rudaz, C., Honeyman, J., Matzaris, M., Watt, M. (2011). Adipose triacylglycerol lipase is a major regulator of hepatic lipid metabolism but not insulin sensitivity in mice. Diabetologia, 54(1), 146-156. [More Information]
Hoy, A., Bruce, C., Turpin, S., Morris, A., Febbraio, M., Watt, M. (2011). Adipose triglyceride lipase-null mice are resistant to high-fat diet-induced insulin resistance despite reduced energy expenditure and ectopic lipid accumulation. Endocrinology, 152(1), 48-58. [More Information]
Wright, L., Brandon, A., Hoy, A., Forsberg, G., Lelliott, C., Reznick, J., LÃ¶fgren, L., Oscarsson, J., StrÃ¶mstedt, M., Cooney, G., et al (2011). Amelioration of lipid-induced insulin resistance in rat skeletal muscle by overexpression of Pgc-1(beta) involves reductions in long-chain acyl-CoA levels and oxidative stress. Diabetologia, 54(6), 1417-1426. [More Information]
Brandon, A., Hoy, A., Wright, L., Turner, N., Hegarty, B., Iseli, T., Xu, J., Cooney, G., Saha, A., Ruderman, N., et al (2011). The evolution of insulin resistance in muscle of the glucose infused rat. Archives of Biochemistry and Biophysics, 509(2), 133-141. [More Information]
Hoehn, K., Turner, N., Swarbrick, M., Wilks, D., Preston, E., Phua, Y., Hoy, A., James, D., Cooney, G., et al (2010). Acute or chronic upregulation of mitochondrial fatty acid oxidation has no net effect on whole-body energy expenditure or adiposity. Cell Metabolism, 11(1), 70-76. [More Information]
Hoehn, K., Salmon, A., Hohnen-Behrens, C., Turner, N., Hoy, A., Maghzal, G., Stocker, R., Van Remmen, H., Kraegen, E., Cooney, G., et al (2009). Insulin resistance is a cellular antioxidant defense mechanism. Proceedings of the National Academy of Sciences of the United States of America, 106(42), 17787-17792. [More Information]
Hoy, A., Brandon, A., Turner, N., Watt, M., Bruce, C., Cooney, G., Kraegen, E. (2009). Lipid and insulin infusion-induced skeletal muscle insulin resistance is likely due to metabolic feedback and not changes in IRS-1, Akt, or AS160 phosphorylation. American Journal of Physiology - Endocrinology and Metabolism, 297(1), E67-E75. [More Information]
Hoy, A., Watt, M. (2009). Lipid Partitioning and Insulin Sensitivity: Lessons learntfrom Genetic Models. Asia-Pacific Journal of Endocrinology (APJOE), 1(1), 35-47.
Bruce, C., Hoy, A., Turner, N., Watt, M., Allen, T., Carpenter, K., Cooney, G., Febbraio, M., Kraegen, E. (2009). Overexpression of carnitine palmitoyltransferase-1 in skeletal muscle is sufficient to enhance fatty acid oxidation and improve high-fat diet-induced insulin resistance. Diabetes, 58(3), 550-558. [More Information]
Hoy, A., Peoples, G., McLennan, P. (2009). The effect of vasoconstrictors on oxygen consumption in resting and contracting skeletal muscle of the autologous pump-perfused rat hindlimb. Journal of Physiology and Pharmacology, 60(3), 155-160. [More Information]
Hoy, A., Turner, N. (2008). New insight into the mechanism by which acute physical exercise ameliorates insulin resistance. Journal of Physiology, 586(9), 2251-2252. [More Information]
Hoy, A., Bruce, C., Cederberg, A., Turner, N., James, D., Cooney, G., Kraegen, E. (2007). Glucose infusion causes insulin resistance in skeletal muscle of rats without changes in Akt and AS160 phosphorylation. American Journal of Physiology - Endocrinology and Metabolism, 293(5), e1358-e1364. [More Information]
Kraegen, E., Saha, A., Preston, E., Wilks, D., Hoy, A., Cooney, G., Ruderman, N. (2006). Increased malonyl-CoA and diacylglycerol content and reduced AMPK activity accompany insulin resistance induced by glucose infusion in muscle and liver of rats. American Journal of Physiology - Endocrinology and Metabolism, 290, e471-e479. [More Information]
Ye, J., Dzamko, N., Hoy, A., Iglesias, M., Kemp, B., Kraegen, E. (2006). Rosiglitazone treatment enhances acute AMP-activated protein kinase-mediated muscle and adipose tissue glucose uptake in high-fat-fed rats. Diabetes, 55(10), 2797-2804. [More Information]

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2024

Scott, J., Quek, L., Hoy, A., Swinnen, J., Nassar, Z., Butler, L. (2024). Fatty acid elongation regulates mitochondrial β-oxidation and cell viability in prostate cancer by controlling malonyl-CoA levels. Biochemical and Biophysical Research Communications, 691, 149273-1-149273-7. [More Information]
Mah, C., Don, A., Mills, I., Swinnen, J., Lynn, D., Nassar, Z., Butler, L., Nguyen, A., Niijima, T., Helm, M., Quek, L., Hoy, A., et al (2024). Peroxisomal β-oxidation enzyme, DECR2, regulates lipid metabolism and promotes treatment resistance in advanced prostate cancer. British Journal of Cancer, 130, 741-754. [More Information]

2023

Dehairs, J., Quek, L., Hoy, A., Swinnen, J., et al (2023). Tracer Lipidomics. Mass Spectrometry for Lipidomics: Methods and Applications, (pp. 641-655). Weinheim, Germany: Wiley-V C H Verlag Gmbh. [More Information]

2022

Jose, J., Hoque, M., Engel, J., Beevi, S., Wahba, M., Georgieva, M., Murphy, K., Hughes, W., Cochran, B., Lu, A., Hoy, A., Grewal, T., et al (2022). Annexin A6 and NPC1 regulate LDL-inducible cell migration and distribution of focal adhesions. Scientific Reports, 12(1), 596. [More Information]
Zipinotti dos Santos, D., Santos Guimaraes, I., Hakeem-Sanni, M., Cochran, B., Rye, K., Grewal, T., Hoy, A., Rangel, L. (2022). Atorvastatin improves cisplatin sensitivity through modulation of cholesteryl ester homeostasis in breast cancer cells. Discover Oncology, 13(1). [More Information]
Mak, B., Lin, H., Kwan, E., Fettke, H., Tran, B., Davis, I., Mahon, K., Stockler, M., Briscoe, K., Marx, G., Hoy, A., Horvath, L., et al (2022). Combined impact of lipidomic and genetic aberrations on clinical outcomes in metastatic castration-resistant prostate cancer. BMC Medicine, 20(1), 112-1-112-14. [More Information]
Quek, L., van Geldermalsen, M., Guan, Y., Wahi, K., Mayoh, C., Balaban, S., Pang, A., Wang, Q., Cowley, M., Brown, K., Hoy, A., et al (2022). Glutamine addiction promotes glucose oxidation in triple-negative breast cancer. Oncogene, 41(34), 4066-4078. [More Information]
Nguyen, M., Jose, J., Wahba, M., Bernaus-Esqué, M., Hoy, A., Enrich, C., Rentero, C., Grewal, T. (2022). Linking Late Endosomal Cholesterol with Cancer Progression and Anticancer Drug Resistance. International Journal of Molecular Sciences, 23(13). [More Information]
Mak, B., Lin, H., Duong, T., Mahon, K., Joshua, A., Stockler, M., Gurney, H., Parnis, F., Zhang, A., Scheinberg, T., Hoy, A., Horvath, L., et al (2022). Modulation of Plasma Lipidomic Profiles in Metastatic Castration-Resistant Prostate Cancer by Simvastatin. Cancers, 14(19). [More Information]

show 3 more

2021

Gillis, J., Hinneh, J., Ryan, N., Irani, S., Moldovan, M., Quek, L., Shrestha, R., Hanson, A., Xie, J., Hoy, A., et al (2021). A feedback loop between the 1 androgen receptor and 6-phosphogluoconate dehydrogenase (6PGD) drives prostate cancer growth: Cooperativity between 6PGD and AR drives prostate cancer growth. eLife, 10, e62592 - 1-e62592 - 27. [More Information]
Kwan, K., Burvenich, I., Centenera, M., Goh, Y., Rigopoulos, A., Dehairs, J., Swinnen, J., Raj, G., Hoy, A., Butler, L., et al (2021). Synthesis and fluorine-18 radiolabeling of a phospholipid as a PET imaging agent for prostate cancer. Nuclear Medicine and Biology, 93, 37-45. [More Information]
Nagarajan, S., Butler, L., Hoy, A. (2021). The diversity and breadth of cancer cell fatty acid metabolism. Cancer and Metabolism, 9(1), 2. [More Information]
Hoy, A., Nagarajan, S., Butler, L. (2021). Tumour fatty acid metabolism in the context of therapy resistance and obesity. Nature Reviews Cancer, 21(12), 753-766. [More Information]

show 1 more

2020

Miladinovic, D., Cusick, T., Mahon, K., Haynes, A., Cortie, C., Meyer, B., Stricker, P., Wittert, G., Butler, L., Horvath, L., Hoy, A. (2020). Assessment of periprostatic and subcutaneous adipose tissue lipolysis and adipocyte size from men with localized prostate cancer. Cancers, 12(6), 1385. [More Information]
Nassar, Z., Mah, C., Centenera, M., Irani, S., Sadowski, M., Scott, J., Nguyen, E., Nagarajan, S., Moldovan, M., Lynn, D., Hoy, A., et al (2020). Fatty Acid Oxidation Is an Adaptive Survival Pathway Induced in Prostate Tumors by HSP90 Inhibition. Molecular Cancer Research, 18(10), 1500-1511. [More Information]
Nassar, Z., Mah, C., Dehairs, J., Burvenich, I., Irani, S., Centenera, M., Helm, M., Shrestha, R., Moldovan, M., Don, A., Horvath, L., Hoy, A., et al (2020). Human decr1 is an androgen-repressed survival factor that regulates pufa oxidation to protect prostate tumor cells from ferroptosis. eLife, 9, 1-34. [More Information]
Krycer, J., Quek, L., Francis, D., Zadoorian, A., Weiss, F., Cooke, K., Nelson, M., Diaz Vegas, A., Humphrey, S., Scalzo, R., Varney, B., Nagarajan, S., Hoy, A., Cooney, G., Fazakerley, D., James, D., et al (2020). Insulin signaling requires glucose to promote lipid anabolism in adipocytes. Journal of Biological Chemistry, 295(38), 13250-13266. [More Information]
Nerstedt, A., Kurhe, Y., Cansby, E., Caputo, M., Gao, L., Vorontsov, E., Ståhlman, M., Nuñez-Durán, E., Borén, J., Marschall, H., Hoy, A., et al (2020). Lipid Droplet-Associated Kinase STK25 Regulates Peroxisomal Activity and Metabolic Stress Response in Steatotic Liver. Journal of Lipid Research, 61(2), 178-191. [More Information]

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2019

Balaban, S., Nassar, Z., Zhang, A., Hosseini Beheshti, E., Centenera, M., Schreuder, M., Lin, H., Aishah, A., Varney, B., Liu-Fu, F., Lee, L., Nagarajan, S., Hardie, R., Raftopulos, N., Kakani, M., Holst, J., Horvath, L., Hoy, A., et al (2019). Extracellular Fatty Acids Are the Major Contributor to Lipid Synthesis in Prostate Cancer. Molecular Cancer Research, 17(4), 949-962. [More Information]
Nagarajan, S., Paul-Heng, M., Krycer, J., Fazakerley, D., Sharland, A., Hoy, A. (2019). Lipid and Glucose Metabolism in Hepatocyte Cell Lines and Primary Mouse Hepatocytes: A comprehensive resource for in vitro studies of hepatic metabolism. American Journal of Physiology - Endocrinology and Metabolism, 316(4), E578-E589. [More Information]

2018

Cairns, R., Fischer, A., Blanco-Munoz, P., Alvarez-Guaita, A., Meneses-Salas, E., Egert, A., Buechler, C., Hoy, A., Heeren, J., Enrich, C., Grewal, T., et al (2018). Altered hepatic glucose homeostasis in AnxA6-KO mice fed a high-fat diet. PloS One, 13(8), 1-26. [More Information]
Balaban, S., Lee, L., Varney, B., Aishah, A., Gao, Q., Shearer, R., Saunders, D., Grewal, T., Hoy, A. (2018). Heterogeneity of fatty acid metabolism in breast cancer cells underlies differential sensitivity to palmitate-induced apoptosis. Molecular Oncology, 12(9), 1623-1638. [More Information]
Attane, C., Milhas, D., Hoy, A., Muller, C. (2018). Metabolic remodeling induced by adipocytes: a new Achille heels in invasive breast cancer? Current Medicinal Chemistry, 25, 1-15. [More Information]
Nassar, Z., Aref, A., Miladinovic, D., Mah, C., Raj, G., Hoy, A., Butler, L. (2018). Peri-prostatic adipose tissue: the metabolic microenvironment of prostate cancer. BJU International, 121(S3), 9-21. [More Information]
Aref, A., Vincent, A., O'Callaghan, M., Martin, S., Sutherland, P., Hoy, A., Butler, L., Wittert, G. (2018). The inverse relationship between prostate specific antigen (PSA) and obesity. Endocrine-Related Cancer, 25(11), 933-941. [More Information]

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2017

Lin, H., Mahon, K., Weir, J., Mundra, P., Spielman, C., Briscoe, K., Gurney, H., Mallesara, G., Marx, G., Stockler, M., Hoy, A., Horvath, L., et al (2017). A distinct plasma lipid signature associated with poor prognosis in castration-resistant prostate cancer. International Journal of Cancer, 141(10), 2112-2120. [More Information]
Balaban, S., Shearer, R., Lee, L., van Geldermalsen, M., Schreuder, M., Shtein, H., Cairns, R., Cooke, K., Fazakerley, D., Grewal, T., Holst, J., Hoy, A., et al (2017). Adipocyte lipolysis links obesity to breast cancer growth: adipocyte-derived fatty acids drive breast cancer cell proliferation and migration. Cancer and Metabolism, 5(1). [More Information]
Hoy, A., Balaban, S., Saunders, D. (2017). Adipocyte-Tumor Cell Metabolic Crosstalk in Breast Cancer. Trends in Molecular Medicine, 23(5), 381-392. [More Information]
Nagarajan, S., Brandon, A., McKenna, J., Shtein, H., Nguyen, T., Suryana, E., Poronnik, P., Cooney, G., Saunders, D., Hoy, A. (2017). Insulin and diet-induced changes in the ubiquitin-modified proteome of rat liver. PloS One, 12(3), 1-14. [More Information]
Hardie, R., van Dam, E., Cowley, M., Han, T., Balaban, S., Pajic, M., Pinese, M., Iconomou, M., Shearer, R., McKenna, J., Hoy, A., et al (2017). Mitochondrial mutations and metabolic adaptation in pancreatic cancer. Cancer and Metabolism, 5, 1-15. [More Information]
Cairns, R., Alvarez-Guaita, A., Martínez-Saludes, I., Wason, S., Hanh, J., Nagarajan, S., Hosseini Beheshti, E., Monastyrskaya, K., Hoy, A., Buechler, C., Grewal, T., et al (2017). Role of hepatic Annexin A6 in fatty acid-induced lipid droplet formation. Experimental Cell Research, 358(2), 397-410. [More Information]

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2016

Meier, E., Rein-Fischboeck, L., Pohl, R., Wanninger, J., Hoy, A., Grewal, T., Eisinger, K., Krautbauer, S., Liebisch, G., Weiss, T., et al (2016). Annexin A6 protein is downregulated in human hepatocellular carcinoma. Molecular and Cellular Biochemistry, 418(1-2), 81-90. [More Information]

2015

Meex, R., Hoy, A., Mason, R., Martin, S., McGee, S., Bruce, C., Watt, M. (2015). ATGL-mediated triglyceride turnover and the regulation of mitochondrial capacity in skeletal muscle. American Journal of Physiology - Endocrinology and Metabolism, 308(11), E960-E970. [More Information]
Meex, R., Hoy, A., Morris, A., Brown, R., Lo, J., Burke, M., Goode, R., Kingwell, B., Kraakman, M., Febbraio, M., et al (2015). Fetuin B Is a Secreted Hepatocyte Factor Linking Steatosis to Impaired Glucose Metabolism. Cell Metabolism, 22(6), 1078-1089. [More Information]
Gao, Q., Hanh, J., Varadi, L., Cairns, R., Sjoestroem, H., Liao, V., Wood, P., Balaban, S., Ong, J., Lin, H., Lai, F., Hoy, A., Grewal, T., Groundwater, P., Hibbs, D. (2015). Identification of dual PPARÎ±/Î³ agonists and their effects on lipid metabolism. Bioorganic and Medicinal Chemistry, 23(24), 7676-7684. [More Information]
Balaban, S., Lee, L., Schreuder, M., Hoy, A. (2015). Obesity and cancer progression: Is there a role of fatty acid metabolism? BioMed Research International, 2015, 1-7. [More Information]
Wang, Q., Hardie, R., Hoy, A., van Geldermalsen, M., Gao, D., Fazli, L., Sadowski, M., Balaban, S., Schreuder, M., Nagarajah, R., Wong, J., Metierre, C., Pinello, N., Otte, N., Bailey, C., Ritchie, W., Rasko, J., Holst, J., et al (2015). Targeting ASCT2-Mediated Glutamine Uptake Blocks Prostate Cancer Growth and Tumour Development. Journal of Pathology, 236(3), 278-289. [More Information]
Kamili, A., Roslan, N., Frost, S., Cantrill, L., Wang, D., Austin, D., Bright, R., Groblewski, G., Straub, B., Hoy, A., Chen, Y., Byrne, J. (2015). TPD52 expression increases neutral lipid storage within cultured cells. Journal of Cell Science, 128(17), 3223-3238. [More Information]

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2014

Briggs, D., Lockie, S., Benzler, J., Wu, Q., Stark, R., Reichenbach, A., Hoy, A., Lemus, M., Coleman, H., Parkington, H., et al (2014). Evidence That Diet-Induced Hyperleptinemia, but Not Hypothalamic Gliosis, Causes Ghrelin Resistance in NPY/AgRP Neurons of Male Mice. Endocrinology, 155(7), 2411-2422. [More Information]
Abboud, M., Gordon-Thomson, C., Hoy, A., Balaban, S., Rybchyn, M., Cole, L., Su, Y., Brennan-Speranza, T., Fraser, D., Mason, R. (2014). Uptake of 25-Hydroxyvitamin D by muscle and fat cells. Journal of Steroid Biochemistry and Molecular Biology, 144(Part A), 232-236. [More Information]

2013

Peoples, G., Hoy, A., Henry, R., McLennan, P. (2013). Autologous pump-perfused rat hind limb preparation for investigating muscle function and metabolism in vivo. Microcirculation, 20(6), 511-523. [More Information]
Boon, J., Hoy, A., Stark, R., Brown, R., Meex, R., Henstridge, D., Schenk, S., Meikle, P., Horowitz, J., Kingwell, B., et al (2013). Ceramides contained in LDL are elevated in type 2 diabetes and promote inflammation and skeletal muscle insulin resistance. Diabetes, 62(2), 401-410. [More Information]
Kim, M., Lee, K., Iseli, T., Hoy, A., George, J., Grewal, T., Roufogalis, B. (2013). Compound K modulates fatty acid-induced lipid droplet formation and expression of proteins involved in lipid metabolism in hepatocytes. Liver International, 33(10), 1583-1593. [More Information]
Bell-Anderson, K., Funnell, A., Williams, H., Jusoh, H., Scully, T., Lim, W., Burdach, J., Mak, K., Knights, A., Hoy, A., Nicholas, H., Salis (nee Sainsbury), A., et al (2013). Loss of Kruppel-Like Factor 3 (KLF3/BKLF) Leads to Upregulation of the Insulin-Sensitizing Factor Adipolin (FAM132A/CTRP12/C1qdc2). Diabetes, 62(8), 2728-2737. [More Information]

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2012

Watt, M., Hoy, A., Muoio, D., Coleman, R. (2012). Distinct roles of specific fatty acids in cellular processes: implications for interpreting and reporting experiments. American Journal of Physiology - Endocrinology and Metabolism, 302(1), E1-E3. [More Information]
Watt, M., Hoy, A. (2012). Lipid metabolism in skeletal muscle: generation of adaptive and maladaptive intracellular signals for cellular function. American Journal of Physiology - Endocrinology and Metabolism, 302(11), e1315-e1328. [More Information]
Watt, M., Barnett, A., Bruce, C., Schenk, S., Horowitz, J., Hoy, A. (2012). Regulation of plasma ceramide levels with fatty acid oversupply: evidence that the liver detects and secretes de novo synthesised ceramide. Diabetologia, 55(10), 2741-2746. [More Information]

2011

Turpin, S., Hoy, A., Brown, R., Rudaz, C., Honeyman, J., Matzaris, M., Watt, M. (2011). Adipose triacylglycerol lipase is a major regulator of hepatic lipid metabolism but not insulin sensitivity in mice. Diabetologia, 54(1), 146-156. [More Information]
Hoy, A., Bruce, C., Turpin, S., Morris, A., Febbraio, M., Watt, M. (2011). Adipose triglyceride lipase-null mice are resistant to high-fat diet-induced insulin resistance despite reduced energy expenditure and ectopic lipid accumulation. Endocrinology, 152(1), 48-58. [More Information]
Wright, L., Brandon, A., Hoy, A., Forsberg, G., Lelliott, C., Reznick, J., LÃ¶fgren, L., Oscarsson, J., StrÃ¶mstedt, M., Cooney, G., et al (2011). Amelioration of lipid-induced insulin resistance in rat skeletal muscle by overexpression of Pgc-1(beta) involves reductions in long-chain acyl-CoA levels and oxidative stress. Diabetologia, 54(6), 1417-1426. [More Information]
Brandon, A., Hoy, A., Wright, L., Turner, N., Hegarty, B., Iseli, T., Xu, J., Cooney, G., Saha, A., Ruderman, N., et al (2011). The evolution of insulin resistance in muscle of the glucose infused rat. Archives of Biochemistry and Biophysics, 509(2), 133-141. [More Information]

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2010

Hoehn, K., Turner, N., Swarbrick, M., Wilks, D., Preston, E., Phua, Y., Hoy, A., James, D., Cooney, G., et al (2010). Acute or chronic upregulation of mitochondrial fatty acid oxidation has no net effect on whole-body energy expenditure or adiposity. Cell Metabolism, 11(1), 70-76. [More Information]

2009

Hoehn, K., Salmon, A., Hohnen-Behrens, C., Turner, N., Hoy, A., Maghzal, G., Stocker, R., Van Remmen, H., Kraegen, E., Cooney, G., et al (2009). Insulin resistance is a cellular antioxidant defense mechanism. Proceedings of the National Academy of Sciences of the United States of America, 106(42), 17787-17792. [More Information]
Hoy, A., Brandon, A., Turner, N., Watt, M., Bruce, C., Cooney, G., Kraegen, E. (2009). Lipid and insulin infusion-induced skeletal muscle insulin resistance is likely due to metabolic feedback and not changes in IRS-1, Akt, or AS160 phosphorylation. American Journal of Physiology - Endocrinology and Metabolism, 297(1), E67-E75. [More Information]
Hoy, A., Watt, M. (2009). Lipid Partitioning and Insulin Sensitivity: Lessons learntfrom Genetic Models. Asia-Pacific Journal of Endocrinology (APJOE), 1(1), 35-47.
Bruce, C., Hoy, A., Turner, N., Watt, M., Allen, T., Carpenter, K., Cooney, G., Febbraio, M., Kraegen, E. (2009). Overexpression of carnitine palmitoyltransferase-1 in skeletal muscle is sufficient to enhance fatty acid oxidation and improve high-fat diet-induced insulin resistance. Diabetes, 58(3), 550-558. [More Information]
Hoy, A., Peoples, G., McLennan, P. (2009). The effect of vasoconstrictors on oxygen consumption in resting and contracting skeletal muscle of the autologous pump-perfused rat hindlimb. Journal of Physiology and Pharmacology, 60(3), 155-160. [More Information]

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2008

Hoy, A., Turner, N. (2008). New insight into the mechanism by which acute physical exercise ameliorates insulin resistance. Journal of Physiology, 586(9), 2251-2252. [More Information]

2007

Hoy, A., Bruce, C., Cederberg, A., Turner, N., James, D., Cooney, G., Kraegen, E. (2007). Glucose infusion causes insulin resistance in skeletal muscle of rats without changes in Akt and AS160 phosphorylation. American Journal of Physiology - Endocrinology and Metabolism, 293(5), e1358-e1364. [More Information]

2006

Kraegen, E., Saha, A., Preston, E., Wilks, D., Hoy, A., Cooney, G., Ruderman, N. (2006). Increased malonyl-CoA and diacylglycerol content and reduced AMPK activity accompany insulin resistance induced by glucose infusion in muscle and liver of rats. American Journal of Physiology - Endocrinology and Metabolism, 290, e471-e479. [More Information]
Ye, J., Dzamko, N., Hoy, A., Iglesias, M., Kemp, B., Kraegen, E. (2006). Rosiglitazone treatment enhances acute AMP-activated protein kinase-mediated muscle and adipose tissue glucose uptake in high-fat-fed rats. Diabetes, 55(10), 2797-2804. [More Information]

Selected Grants

2023

Androgen receptor: A master regulator of lipid metabolism, Hoy A, Australian Research Council (ARC)/Discovery Projects (DP)
Exploiting Prostate Cancer Metabolic Dependencies to Develop New Therapeutics and Circulating Prognostic and Predictive Biomarkers, Hoy A, Horvath L, US Department of Defence (USA)/Research Grants

2022

Targeting Rab7 and TBC1D15 to normalize cellular cholesterol distribution in NPC1 disease, Grewal T, Hibbs D, Groundwater P, Hoy A, University of Notre Dame/Ara Parseghian Medical Research Fund (APMRF)

2019

Unravelling the Metabolic Link between the Host and Breast Cancer Disease Progression, Hoy A, University of Sydney/Sydney Catalyst Pilot - Seed Funding Grant

2018

Cellular Lipid Biology, Hoy A, DVC Research/Robinson Fellowships (SIF)

2017

Unravelling the link between liver lipid droplet metabolism and insulin resistance, Hoy A, Sydney Medical School Foundation/SMS Interim Support Scheme

2016

Lipid and prostate cancer, Hoy A, DVC Research/Bridging Support Grant
Targeting Glutamine metabolism to starve triple-negative breast cancer, Holst J, Beith J, Hoy A, Quek L, University of Sydney - Sydney Catalyst Translational Cancer Research/Pilot and Seed Funding

2015

Exploiting alterations in lipid metabolism to improve diagnosis, treatment and molecular imaging of prostate cancer, Butler L, Hoy A, Prostate Cancer Foundation of Australia/Movember Revolutionary Team Awards

2014

Linking Cancer Progression to Altered Lipid Metabolism in Obesity, Hoy A, Sydney Medical School/Helen and Robert Ellis Postdoctoral Research Fellowship
Fat cells in obesity and breast cancer - fatty acids metabolism as a potential link, Hoy A, DVC Research/Bridging Support Grant