student profile: Mr Yori Yuliandra


Thesis work

Thesis title: Design, Synthesis and Testing of New Anti-Bacterial Agents by Targeting FtsZ Protein

Supervisors: David HIBBS , Paul GROUNDWATER

Thesis abstract:

FtsZ (Filamenting temperature-sensitive mutant Z) is an essential protein in bacterial cell division encoded by ftsZ gene. This protein is considered as a tubulin homolog and is highly conserved among pathogenic bacteria. This situation makes FtsZ as a promising target for the new development of antibacterial agents in the treatment of infectious diseases. Some potential substances have been developed and reported to exhibit inhibitory activity on FtsZ. The search for more potent inhibitor agents is encouraged through natural products-based and synthetic drug discovery programs.

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