Our initiative focuses on designing and developing innovative tools and techniques to identify novel therapeutic targets, delivery mechanisms, and bioactive molecules with high potential for industry uptake and clinical translation. It is built on collective expertise in drug discovery research from across the University, underpinned by state-of-the-art infrastructure and input from industry and clinical advisory groups.
This multidisciplinary and collaborative approach will drive research in early-stage drug discovery by:
Through Sydney Analytical, we have a suite of facilities to support and accelerate early-stage drug discovery including:
While therapies and prognoses for most cancers have improved drastically over the last two decades, there is still huge potential for further improvement through the development of targeted interventions and treatments, and a better understanding of the genetic and molecular mechanisms of cancers. We are working to develop bioactive molecules that enhance the understanding, prevention, and treatment of cancers.
With incidences of drug resistance increasing across many infectious diseases, there is a pressing need to develop new and more effective treatments. Our researchers are working to overcome disease resistance by discovering new targets and lead compounds to tackle diseases such as tuberculosis, malaria and fungal infections.
Regulating the body’s inflammatory responses for treating pain and inflammation have applications in a growing list of disorders. Our research focuses on the identification and validation of novel targets implicated in pain, inflammation and autoimmunity, with potential applications in the understanding and treatment of cancers, central nervous system, metabolic and cardiovascular disorders.
Neurodegenerative and central nervous system disorders such as dementia and systemic pain, are becoming increasingly prevalent with increasing life-spans. We are working to identify targets and develop lead compounds that selectively modulate the central nervous system.
Diseases relating to metabolic and cardiovascular disorder, such as diabetes and obesity, represent a rapidly growing health problem in Australia and globally. Our researchers are pursuing therapeutic leads to target such diseases.
We work closely with the following centres and initiatives across these five disease focus areas:
The Drug Discovery Initiative is supported by its team, members, and partners, underpinned by the University of Sydney’s Research Portfolio.
We are a point of contact for internal researchers looking to connect with complementary capability in the area of drug discovery research, or for external stakeholders looking to engage with our researchers.