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Throughout life, human diarthrodial joints must bear the loads associated with physical activity, a process enabled by the cartilage-bone interface, or osteochondral (OC) unit. Diseases such as osteoarthritis (OA) cause pathological changes to the OC unit, leading to cartilage destruction, sclerotic bone, and pain, often necessitating total joint arthroplasty (TJA). TJA patients face a high lifetime risk of revision surgeries, highlighting the need for alternative tissue-engineered solutions.
This project aims to use natural materials to bioengineer patient-specific OC grafts that closely mimic the architecture, zonal organization, and functional properties of native OC tissue. We will utilize 3D computer models based on native subchondral bone architecture to print high-resolution models from a bioceramic known for its toughness, strength, and osseointegrative properties. Cellular layers of hyaline and calcified cartilage will be bonded to the bioceramic base and matured in a bioreactor until they match the native tissue.
Offering:
A PhD scholarship for 3.5 years. International applicants will have their tuition fees covered.
The project is funded by the Swiss National Foundation in Collaboration with ETH-Zurich, Switzerland.
Successful candidates must:
How to Apply:
To apply, please email hala.zreiqat@sydney.edu.au the following:
The position will be available in early 2025.
The opportunity ID for this research opportunity is 3451