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Metal Ion Sensors for Medicinal and Environmental Applications

Metal cations like Zn(II), Cu and K(I) play a raft of important signalling roles in our bodies; others such as Hg(II), Cd(II) and Pb(II) are toxic pollutants in the environment. more...

Supervisor(s): Rutledge, Peter (Professor), Canning, John (Honorary Professor)

Function and regulation of P-type ATPase ion pumps

The project aims to understand at the atomic level how the Na+,K+-ATPase and related ion pumps function and how they are regulated. more...

Supervisor(s): Clarke, Ron (Associate Professor)

Synaptic signalling therapies for anti-acetylcholine receptor myasthenia gravis

This project will use a mouse model to test potential treatments for the autoimmune disease, anti-acetylcholine receptor myasthenia gravis. more...

Supervisor(s): Phillips, William (Bill) (Associate Professor)

Muscle specific kinase in synaptic adaptation

This project will investigate the role of postsynaptic Muscle specific Kinase (MuSK) in regulating presynaptic neurotransmitter release at the neuromuscular junction. more...

Supervisor(s): Phillips, William (Bill) (Associate Professor), Protti, Dario (Dr)

Turbulence-chemistry interactions in piloted premixed flames

The objective of the project is to improve current capabilities to compute the structure of turbulent premixed flames where the interactions between turbulence and chemistry are hig more...

Supervisor(s): Masri, Assaad (Professor)

A cell culture model for Muscle Specific Kinase myasthenia gravis

The postsynaptic membrane of the neuromuscular junction (NMJ) is organized by Muscle specific tyrosine kinase (MuSK). This project will investigate the mechanisms that organize the more...

Supervisor(s): Phillips, William (Bill) (Associate Professor)

How do herpes simplex viruses interact with dendritic cells in human skin: clues for vaccine development

Herpes Simplex Virus (HSV) can cause cold sores, genital herpes, keratitis, encephalitis and neonatal herpes. 70-80% of human population is infected with HSV-1 and 22% with HSV-2. O more...

Supervisor(s): Cunningham, Tony (Professor), Kim, Min (Dr)

Phosphate homeostasis and fungal virulence

Inorganic phosphate (Pi) is an important macronutrient for all living organisms including yeast, and is essential for ATP, phospholipid and protein synthesis, metabolism and signall more...

Supervisor(s): Djordjevic, Julianne (Dr), Sorrell, Tania (Professor)

Design of new metal-based anti-cancer drugs

This project aims to investigate the mode of action of metal anti-cancer drugs, including both anti-metastatic and cytotocities against a range of different cancer cell lines.  more...

Supervisor(s): Lay, Peter (Professor)

Targeting melanoma secretory pathways.

Cancer cells secrete a variety of factors that induce tumour growth, metastasis, angiogenesis, and alter the tumour stroma to create a more favourable microenviroment. This project more...

Supervisor(s): Weninger , Wolfgang (Professor), Beaumont, Kimberley (Dr)