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UNDERSTANDING GENETIC VARIATIONS IN BONE

Functional genomics is a field that is undergoing major changes in practice due to the accessibility of gene editing technologies. Our team has developed methods for gene editing in more...

Supervisor(s): Schindeler, Aaron (Associate Professor), Munns, Craig (Associate Professor)

GENE THERAPY FOR GENETIC BONE DISEASES

Gene therapy is becoming a practical approach to treat severe genetic conditions and in recent years conditions such as Spinal Muscular Atrophy (SMA) have been success stories. Our more...

Supervisor(s): Schindeler, Aaron (Associate Professor), Munns, Craig (Associate Professor)

Defining the genetic link between nitrate and ammonium transport proteins and root architecture in Maize and Barley

We have previously tested two contrasting maize inbred lines on their inherent nitrate transport rates and respective responses to growth at low nitrogen supply. The lines were sele more...

Supervisor(s): Kaiser, Brent (Professor)

Genetics of Healthy Ageing

By exploiting the vast genetic landscape of an outbred mouse population we aim to explore the molecular cause of a range of diseases that limit healthy ageing in humans. This includ more...

Supervisor(s): James, David (Professor)

A Novel Role in Stabilizing Vulnerable Atherosclerotic Plaque

Atherosclerosis is the leading cause of cardiovascular deaths, accounting for ~30% of all deaths in Australia in 2018. Atherosclerotic plaque rupture leads to heart failure and stro more...

Supervisor(s): Misra, Ashish (Dr)

Define regulatory control pathways delivering NPF (nitrate) and AMT (ammonium) transport activities across root types and cell profiles

We have previously identified the tissue expression patterns of ZmNPF6;6 and ZmNPF6;4 in maize root tips (Wen, Z., et al., The Plant Cell, 2017) and used qPCR as well as custom arra more...

Supervisor(s): Kaiser, Brent (Professor)

A structural view and understanding of NPF (nitrate transport) protein activity in maize

This PhD project will develop and analyse high quality crystallised proteins of the nitrate/chloride transport proteins ZmNPF6;4, ZmNPF6;4 (Y370H) and ZmNPF6;6. The goal will be to more...

Supervisor(s): Kaiser, Brent (Professor)

Modulating coronary atherosclerosis through perivascular fat (PVAT)

Background: Organ-to-organ communications are vital for living systems and play critical roles in cellular homeostasis. Various studies have demonstrated the existence and significa more...

Supervisor(s): Misra, Ashish (Dr)

PRECLINICAL AND CLINICAL DEVELOPMENT OF NOVEL BONE-BINDING ANTIMICROBIALS

Our team has spent several years developing and testing new a new class of drugs termed bone-binding antimicrobials (BBAs). Our lead compound (BBA-1) has been shown to have antimicr more...

Supervisor(s): Schindeler, Aaron (Associate Professor), Little, David (Professor)

Curing antibiotic resistance plasmid from Enterobacteriaceae

The project includes to understand the biology of antibiotic resistance plasmids and develop effective strategy to cure them more...

Supervisor(s): Kamruzzaman, Muhammad (Dr), Iredell, Jon (Professor)