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Targeting Rab7 and TBC1D15 to overcome mitochondrial dysfunction in neurological diseases

Pharmacological manipulation of contacts between mitochondria and LE/Lys could provide opportunities to improve PD, CMT2B and NPC disease. Virtual screening of compound libraries wi more...

Supervisor(s): Grewal , Thomas (Associate Professor), Groundwater, Paul (Professor), Hibbs, David (Dai) (Professor)

Ageing Blood Vessels

Techniques: high resolution imaging, use of new imaging platforms such as ImageStream, molecular biology, tissue culture, in vitro models of disease, flow cytometry, establishment o more...

Supervisor(s): Gamble, Jennifer (Professor)

Alzheimer’s Disease and Blood Vessels

Techniques: single cell RNAsequencing and gene expression analysis, high resolution imaging, molecular biology, tissue culture, in vitro models of disease, flow cytometry, some anim more...

Supervisor(s): Gamble, Jennifer (Professor)

Artificial Intelligence in Ion Channel Drug Discovery

Application of machine learning and artificial intelligence methods to develop models predictive of drug activity, selectivity, stability and distribution. The project will be condu more...

Supervisor(s): Balle, Thomas (Associate Professor)

Fluorescent Tools for Super-resolution Imaging

This PhD project will involve the synthesis and characterization of innovative fluorescent sensors for specific amyloid proteins implicated in neurodegenerative disorders. The devel more...

Supervisor(s): Kaur, Amandeep (Dr), Sunde, Margaret (Associate Professor)