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Mining genomic data to understand diseases

In this project, we aim to develop, apply ,and enhance bioinformatics and statistical tools to effectively collate, query, and mine public data repositories of transcription factor more...

Supervisor(s): Khushi, Matloob (Dr)

Whole genome CRISPR screening to define drug mechanism of action

This project will involve new whole genome CRISPR editing strategies, coupled with bioinformatics analysis, to identify the complete molecular mechanism of action for relevant human more...

Supervisor(s): Neely, Greg (Associate Professor)

Machine learning of -omic data for discovery of disease processes.

This project builds on a number of recent findings and aims to bring together omics data related to disease and machine learning for the prediction of transcriptional regulators inv more...

Supervisor(s): Waardenberg, Ashley (Dr), Arthur , Jonathan (Associate Professor)

The HAMLET molecular species with anticancer properties

We are interested to determine how the anti-cancer properties of this family of molecules can be translated into cancer treatment. We believe there may be a delivery system which n more...

Supervisor(s): Church, W Bret (Dr)

Pathways to therapies in blinding genetic retinal eye diseases

In this project, novel disease genes and variants are identified that cause blinding retinal eye diseases. Cellular, gene editing, proteomic and animal model approaches are taken to more...

Supervisor(s): Jamieson, Robyn (Associate Professor)

Discovery and analysis of signalling pathways and mechanisms underlying learning and memory

This project will aim to discover and validate new molecular mechanisms of how synaptic plasticity is regulated by proteins interactions at the neurotransmitter releases sites and p more...

Supervisor(s): Graham, Mark (Dr)

Genomic medicine for unravelling the challenges of pathogenesis and treatment of blindness due to childhood cataract and glaucoma

Novel disease genes and variants are identified that contribute to the blinding eye diseases of childhood cataract and glaucoma.  In this project further novel variants will be more...

Supervisor(s): Jamieson, Robyn (Associate Professor)

The regulation of neurotransmitter release by active zone proteins

This project will aim to discover and validate new molecular mechanisms of how neurotransmitter release and synaptic plasticity is regulated by active zone protein interactions and more...

Supervisor(s): Graham, Mark (Dr)

Computational Modeling of Immune Cell Chemotaxis and Swarming

 Using computational simulation to form and evaluate hypotheses concerning the factors that drive immune cell motility, such as neutrophil swarming, during inflammation. more...

Supervisor(s): Read, Mark (Dr)

Conserved mechanisms of chronic pain

This project involves combining human genomics data for chronic pain disease with high throughput behavioral genomics techniques in fruit fly in order to better understand how chron more...

Supervisor(s): Neely, Greg (Associate Professor)