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Dissecting the architecture of the Insulin Signaling Pathway

The aim of this pathway is to understand how the insulin signalling pathway regulates metabolic homeostasis.The Lead Supervisor for this project is David James. This project will a more...

Supervisor(s): James, David (Professor)

Define regulatory control pathways delivering NPF (nitrate) and AMT (ammonium) transport activities across root types and cell profiles

We have previously identified the tissue expression patterns of ZmNPF6;6 and ZmNPF6;4 in maize root tips (Wen, Z., et al., The Plant Cell, 2017) and used qPCR as well as custom arra more...

Supervisor(s): Kaiser, Brent (Professor)

PhD project(s) in the intersection between obesity and eating disorders

We are seeking a motivated and enthusiastic health researcher to undertake a full time or part-time PhD based at The Children's Hospital at Westmead and enrolled through the Univers more...

Supervisor(s): Lister, Natalie (Dr), Baur, Louise (Professor), Garnett, Sarah (Dr), Maguire, Sarah (Dr), Jebeile, Hiba (Dr)

Molecular Mechanism of Insulin Resistance

Insulin resistance is a major physiological problem that is associated with an inability of insulin to regulate glucose and lipid metabolism. We now know that metabolism is central more...

Supervisor(s): James, David (Professor)

Ageing Blood Vessels

Techniques: high resolution imaging, use of new imaging platforms such as ImageStream, molecular biology, tissue culture, in vitro models of disease, flow cytometry, establishment o more...

Supervisor(s): Gamble, Jennifer (Professor)

UNDERSTANDING GENETIC VARIATIONS IN BONE

Functional genomics is a field that is undergoing major changes in practice due to the accessibility of gene editing technologies. Our team has developed methods for gene editing in more...

Supervisor(s): Schindeler, Aaron (Associate Professor), Munns, Craig (Associate Professor)

GENE THERAPY FOR GENETIC BONE DISEASES

Gene therapy is becoming a practical approach to treat severe genetic conditions and in recent years conditions such as Spinal Muscular Atrophy (SMA) have been success stories. Our more...

Supervisor(s): Schindeler, Aaron (Associate Professor), Munns, Craig (Associate Professor)

PRECLINICAL AND CLINICAL DEVELOPMENT OF NOVEL BONE-BINDING ANTIMICROBIALS

Our team has spent several years developing and testing new a new class of drugs termed bone-binding antimicrobials (BBAs). Our lead compound (BBA-1) has been shown to have antimicr more...

Supervisor(s): Schindeler, Aaron (Associate Professor), Little, David (Professor)

Development of Tissue-Targeted Vectors for Musculoskeletal Gene Therapy

A unique opportunity is available for an outstanding PhD scholar to conduct research in developing tissue-targeted AAV vectors for gene delivery and CRISPR gene editing. more...

Supervisor(s): Schindeler, Aaron (Associate Professor)