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Computational approaches to elucidate Multiple Sclerosis and Contact Dermatitis pathogenesis, and its treatment through ultraviolet light exposure

Allergies and autoimmunity are complex immune system aberrations. Both involve multiple immune cell populations coordinating across several organs of the body. The growing prevalenc more...

Supervisor(s): Read, Mark (Dr)

Control of complement cascade by labile disulphide bonds

The complement system is a key component of innate immunity that offers sophisticated protection against threats to the host organism. Complement is also an important component of t more...

Supervisor(s): Chiu, Joyce (Dr)

The Gene Environment Interaction

-Interrogating how different diets interact with genetics in different inbred mouse strains -Examining the genetic and environmental influence on tissue specific metabolomics -Exam more...

Supervisor(s): James, David (Professor)

Regulation of Lipid Turnover in the body

The project involves characterisation of a novel lipolysis regulator in adipocytes. more...

Supervisor(s): James, David (Professor)

The role of redox in signalling: assessing the requirement of reactive oxygen species in signal transduction

Define the role of ROS in insulin signal transduction and explore how loss of control of this process causes diseases such as diabetes and cancer more...

Supervisor(s): James, David (Professor)

Design of Novel Biosensors and Microfluidic Devices for Interrogating the Insulin Signalling Pathway

The aim of this project is to design, engineer and validate novel biosensors that can be used to interrogate the insulin signalling pathway in live cells. more...

Supervisor(s): James, David (Professor)

Control of immune cell activity via a redox switch in integrin

Our immune system protects us from invasion of pathogens and toxic materials. Immune cells such as monocytes and neutrophils circulate in the blood to monitor foreign materials and more...

Supervisor(s): Chiu, Joyce (Dr)

Display of Viral Surface Glycoprotein on Virus like particles (VPLS) for Structure and Immune Epitope Discovery

Unanchored recombinant soluble monomers are often the proteins used in many structure analyses and immunologic testing. But in reality viral surface glycoproteins are orientated, te more...

Supervisor(s): Lynch, Garry (Dr)

STUDIES OF VARIABLE OR CONSERVED SURFACE PROTEIN SITES OF NEISSERIA MENINGITIDIS AS EPITOPES FOR STRAIN-SPECIFIC VACCINES OR BROAD-STRAIN (UNIVERSAL) VACCINES

The gram-negative Neisseria Meningititis (NM) remains a significant microbial problem and particularly lethal for the very young. Serogroup B strains are particularly troublesome an more...

Supervisor(s): Lynch, Garry (Dr)