Fluorescent sensors for oxidative stress

Summary

Oxidative stress is associated with all diseases of ageing, and there is therefore a need for better tools to identify and quantify the condition. We are developing novel fluorescent sensors of oxidative stress.

Supervisor(s)

Associate Professor Elizabeth New

Research Location

School of Chemistry

Program Type

Masters/PHD

Synopsis

This project will involve the design, synthesis and application of small molecule redox sensors based on organic molecules. Sensors will contain a fluorophore (or multiple fluorophores) tethered to both a redox-sensitive group and a targeting domain. Following synthesis of these molecules, we will study the photophysical properties of our systems, which will enable us to improve upon our probe design. Promising probes will be used to study models of disease in cultured cells. We will then work with collaborators to use our probes in more complex biological systems.

Additional Information

This project is suited to students with an interest in the applications of chemistry in biology. Research will involve chemical synthesis, spectroscopy and simple cellular studies, with collaborations in place for the study of more complex biological systems.

In addition to the academic requirements set out in the Science Postgraduate Handbook, you may be required to satisfy a number of inherent requirements to complete this degree. Example of inherent requirement may include:

  • Confidential disclosure and registration of a disability that may hinder your performance in your degree; Confidential disclosure of a pre-existing or current medical condition that may hinder your performance in your degree (e.g. heart disease, pace-maker, significant immune suppression, diabetes, vertigo, etc.);
  • Ability to perform independently and/or with minimal supervision;
  • Ability to undertake certain physical tasks (e.g. heavy lifting);
  • Ability to undertake observatory, sensory and communication tasks;
  • Ability to spend time at remote sites (e.g. One Tree Island, Narrabri and Camden);
  • Ability to work in confined spaces or at heights;
  • Ability to operate heavy machinery (e.g. farming equipment);
  • Hold or acquire an Australian driver’s licence;
  • Hold a current scuba diving license;
  • Hold a current Working with Children Check;
  • Meet initial and ongoing immunisation requirements (e.g. Q-Fever, Vaccinia virus, Hepatitis, etc.)

You must consult with your nominated supervisor regarding any identified inherent requirements before completing your application.

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Keywords

Molecular imaging, oxidative stress, fluorescent sensor, live cell imaging, ratiometric probe

Opportunity ID

The opportunity ID for this research opportunity is: 1514

Other opportunities with Associate Professor Elizabeth New