Nutrient regulation of the stem cell compartment

Summary

Australia is among the countries with the fastest growing rates of overweight and obesity, which by 2025 will affect >70% of the population. Chronic diseases linked to obesity include type 2 diabetes, cardiovascular disease, cancer and fatty liver. In all these diseases, the metabolic milieu is characterized by low-grade inflammation that is ultimately modulated by nutrient intake. Macrophages play a pivotal role in this obesity-mediated inflammation. Our recent work suggests that cholesterol in the diet can change the rate of release of hematopoietic stem cells and progenitor cells (HSPCs) from the bone marrow. These cells can we believe, subsequently differentiate to inflammatory cells. This project will investigate the mechanisms by which the cholesterol content of the diet affects the function of the bone marrow stem cell niche that leads to the mobilization of stem cells.

Supervisor(s)

Professor Jacob George

Research Location

Westmead - Westmead Institute for Medical Research

Program Type

PHD

Synopsis

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Additional Information

Associate Supervisor - Dr Saeed ESMAILIThe study will be suitable for an Honors project or PhD studies.

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Keywords

Obesity, chronic disease, macrophages

Opportunity ID

The opportunity ID for this research opportunity is: 1910

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