Immuno-metabolism of macrophages in inflammatory diseases

Summary

In metabolic organs like the liver and fat, macrophage infiltration plays a pivotal role in driving low-grade chronic inflammation that results in many of the consequences of obesity such as type 2 diabetes, heart and liver disease, and cancer. Our work suggests that alterations in macrophage metabolism are a key driver of the inflammatory state that ultimately contributes to the development of these diseases. This project investigates the link between glycolysis in macrophages and the glycolysis-dependent switch of macrophages to an inflammatory phenotype. Completion of this project will shed light on the metabolism of inflammatory cells as well as of cancer cells. The project will involve experiments on mice and in vitro studies on human monocyte derived macrophages.

Supervisor(s)

Professor Jacob George

Research Location

Westmead - Westmead Institute for Medical Research

Program Type

N/A

Synopsis

It will be suitable for an Honors project or PhD studies.

Additional Information

Associate Supervisor - Dr Saeed ESMAILI

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Keywords

Liver, macrophages, Obesity

Opportunity ID

The opportunity ID for this research opportunity is: 1911

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