Antimicrobial coatings to prevent orthopaedic implant infection

Summary

To improve treatment of bone and joint infections, this project will examine the delivery of a new antimicrobial compound via orthopaedic implants.


Supervisor(s)

Associate Professor Aaron Schindeler

Research Location

Westmead - Childrens Hospital at Westmead Clinical School

Program Type

PHD

Synopsis

Joint infection is a major source of cost and morbidity in the health systems, and is a growing concern with the emergence of multi drug-resistant microbes. Once a bone infection is present, treatment can be challenging and many pathogens are acquiring resistance to commonly used antibiotics. In particular, drug-resistant strains of staphylococcus aureus are a challenge and can lead to delayed or non-union, sepsis, amputation, and in some cases death.

We have identified a new candidate compound with dual properties as an antibiotic and as a bone repair agent. We are looking for a student to examine the functionality of this agent in joint replacement. Data from previous research projects has shown that it can prevent infection as an implant coating, however we hypothesize that delivery via different biomaterials may improve its antibiotic and bone formation effects in vivo.

This project would suit a student with a biomedical science or biomedical engineering background, particularly with an interest in preclinical translation and biomaterials.

Additional Information

PhD scholarships/APA top-ups are available and will be judged based on the strength of the applicant. For more information contact Dr Aaron Schindeler on + 61 2 9845 1451

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Keywords

Bone, infection, CSA, CSA-90, Osteomyelitis, Orthopaedics, implants, Biomaterials, drug delivery

Opportunity ID

The opportunity ID for this research opportunity is: 2239

Other opportunities with Associate Professor Aaron Schindeler