Structure, Function, Gene Therapy and Surgery in Retinal Dystrophies

Summary

Structure, Function, Gene Therapy and Surgery in Retinal Dystrophies

Supervisor(s)

Associate Professor Matthew Simunovic

Research Location

Camperdown - Central Clinical School - Save Sight Institute

Program Type

Masters/PHD

Synopsis

Hereditary diseases of the retina affect up to 1 in 3,000 individuals and are now the commonest cause of blindness registration in persons of working age. This project is aimed at:
1. Assessing the effects of hereditary retinal diseases on vision and retinal structure in patients with known genotypes.
2. Modelling different modes of surgical delivery of therapeutic substances into the sub-retinal space.
3. Assessing expression of viral vectors in human retinal explants.
4. Developing novel optogenetic approaches to vision restoration in pre-clinical (including human retinal explant) and clinical models.This is a multi-facetted project with clinical and bench-side components. Accordingly, it could be tailored to the interests and background of prospective applicants.

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Keywords

ophthalmology, retina, Vision, Gene therapy, surgery

Opportunity ID

The opportunity ID for this research opportunity is: 2266

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