The effect of assisted reproductive technologies on embryo development and postnatal health.

Summary

Postgraduate research studentship in the analysis of the effects of assisted reproductive technology on the normal development of the embryo. The host lab is a pioneer in the development of all modern forms of assisted reproductive technology. A priority is to now understand the extent to which these technologies perturb the normal molecular and cellular processes of embryo development. The implications of these changes for the subsequent normal health of the postnatally is a further important priority. The research program will investigate how assisted reproductive technologies influence normal patterns of histone and DNA methylation deposition within the nuclei within the gametes and early embryo and how this influences the normal processes of gene expression, cell growth and survival, and the normal processes of cellular differentiation.

Supervisor(s)

Professor Chris O'Neill

Research Location

North Shore - Kolling Institute of Medical Research

Program Type

Masters/PHD

Synopsis

This research program investigate how the major components of assisted reproductive technology, including in vitro fertilisation, cryopreservation, and embryo biopsy influences the normal processes of embryo development. This is done in collaboration with clinical assisted reproductive technology programs and provides direct insight into the optimal processes for use of these technologies.
Research will involve detailed molecular analysis of embryo development in model systems as well detailed statistical analysis of clinical embryo development outcomes following the use of various forms of assisted reproductive technology. The research program will provide an ideal introduction and training in modern forms of assisted reproductive technology.

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Keywords

embryo, epigenetic, gene expression, stem cell, embryonic stem cell, sperm, oocyte, fertilisation, Differentiation, genetic, DNA, methylation, Transcription, in vitro fertilisation, assisted reproductive technology, developmental origins of disease, chromatin, histone, Bioinformatics

Opportunity ID

The opportunity ID for this research opportunity is: 2322

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