Analysis of Human Responses to Intermittent Fasting

Summary

Analysis of human samples generated from intervention-based clinical trials of intermittent fasting. Our aim is to understand the molecular mechanisms mediating the beneficial phenotypes generated by intermittent fasting.

Supervisor(s)

Dr Mark Larance

Research Location

Charles Perkins Centre – the Judith and David Coffey Life Lab

Program Type

PHD

Synopsis

Though collaborations we have access to both blood plasma and tissues derived from patients who have undergone intermittent fasting. Samples were collected before and after the intermittent fasting intervention, allowing a longitudinal analysis. This project will include method development in sample preparation for the enhanced detection of hormones thought to be important for the response to intermittent fasting. These samples will be analysed in our lab by mass spectrometry-based proteomics. These data will be subsequently processed for large-scale data analysis. Such datasets will provide the first unbiased insights into the intermittent fasting response in humans. The importance of novel targets detected will then be further characterised in animal models.

Additional Information

In addition to the academic requirements set out in the Science Postgraduate Handbook, you may be required to satisfy a number of inherent requirements to complete this degree. Example of inherent requirement may include:

  • Confidential disclosure and registration of a disability that may hinder your performance in your degree;
  • Confidential disclosure of a pre-existing or current medical condition that may hinder your performance in your degree (e.g. heart disease, pace-maker, significant immune suppression, diabetes, vertigo, etc.);
  • Ability to perform independently and/or with minimal supervision;
  • Ability to undertake certain physical tasks (e.g. heavy lifting);
  • Ability to undertake observatory, sensory and communication tasks;
  • Ability to spend time at remote sites (e.g. One Tree Island, Narrabri and Camden);
  • Ability to work in confined spaces or at heights;
  • Ability to operate heavy machinery (e.g. farming equipment);
  • Hold or acquire an Australian driver’s licence;
  • Hold a current scuba diving license;
  • Hold a current Working with Children Check;
  • Meet initial and ongoing immunisation requirements (e.g. Q-Fever, Vaccinia virus, Hepatitis, etc.)

You must consult with your nominated supervisor regarding any identified inherent requirements before completing your application.

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Keywords

human, fasting, Proteomics, Biochemistry, nutrition, metabolism, blood, clinical trial

Opportunity ID

The opportunity ID for this research opportunity is: 2449

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