Mechanisms of Transgenerational Epigenetic inheritance

Summary

We are interested in understanding the molecular mechanisms that allow a phenomenon called epigenetic inheritance to occur: that is, the transmission of non-genetic information from parent to offspring. This project uses cutting edge technology combined with classic genetics in model organisms to try and answer this fundamental question.

Supervisor(s)

Dr Alyson Ashe

Research Location

School of Life and Environmental Sciences

Program Type

PHD

Synopsis

The project will use CRISPR/Cas9 gene editing technology to make targeted alterations to the model organism's genome. The mutants generated, combined with novel sequencing techniques, proteomics and high resolution microscopy will deliver insights into the way epigenetic inheritance works.

We will also be collaborating with other groups to perform structural biology assays to define the structure of novel proteins that we are studying.

Additional Information

HDR Inherent Requirements

In addition to the academic requirements set out in the Science Postgraduate Handbook, you may be required to satisfy a number of inherent requirements to complete this degree. Example of inherent requirement may include:

- Confidential disclosure and registration of a disability that may hinder your performance in your degree;
- Confidential disclosure of a pre-existing or current medical condition that may hinder your performance in your degree (e.g. heart disease, pace-maker, significant immune suppression, diabetes, vertigo, etc.);
- Ability to perform independently and/or with minimal supervision;
- Ability to undertake certain physical tasks (e.g. heavy lifting);
- Ability to undertake observatory, sensory and communication tasks;
- Ability to spend time at remote sites (e.g. One Tree Island, Narrabri and Camden);
- Ability to work in confined spaces or at heights;
- Ability to operate heavy machinery (e.g. farming equipment);
- Hold or acquire an Australian driver’s licence;
- Hold a current scuba diving license;
- Hold a current Working with Children Check;
- Meet initial and ongoing immunisation requirements (e.g. Q-Fever, Vaccinia virus, Hepatitis, etc.)

You must consult with your nominated supervisor regarding any identified inherent requirements before completing your application.

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Keywords

epigenetics, RNA, Genetics, gene regulation, next generation sequencing

Opportunity ID

The opportunity ID for this research opportunity is: 2493