Postgraduate Research Stipend to develop cannabinoids as potential therapeutics to treat myasthenia gravis

Summary

This Scholarship will provide a stipend towards the living expenses of a PhD student to learn to use intracellular electrophysiological recordings to develop cannabinoid compounds as potential new drugs to restore synaptic function in mouse models of myasthenia gravis.

Supervisor(s)

Associate Professor William (Bill) Phillips

Research Location

Camperdown - Boden Institute of Obesity, Nutrition, Exercise & Eating Disorders

Program Type

PHD

Synopsis

Myasthenia gravis is a neuromuscular disease in which muscle weakness is caused by failure of synaptic transmission at the neuromuscular junction. Current treatments aim to reduce the levels of harmful autoimmune antibodies and to improve synaptic function, but additional new treatment options are needed. This Scholarship is available for a PhD student to undertake a specific project: using intracellular electrophysiological recordings to develop and test cannabinoid-like compounds as potential future drugs to treat diseases of the neuromuscular synapse. The project will build upon recent work of the supervisors (Morsch, Protti, Cheng, Braet, Chung, Reddel & Phillips. 2018. Sci Rep 8, 4685). The candidate will be based in the Discipline of Physiology, University of Sydney. The scholarship will help support the living costs of the student while they complete their studies.

Additional Information

• The candidate will learn to master intracellular electrophysiology and pharmacology
• An experienced electrophysiologist will train you during 2019
• Applicants must hold an Honours degree (First Class) or a Master's degree in a related field with a substantial research component, or equivalent.
• This Stipend Scholarship will provide an annual stipend allowance equivalent to the minimum RTP rate. The recipient may apply for an extension of up to 6 months.
• The Scholarship is for commencement in early 2019 and cannot be deferred or transferred to another area of research.

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Keywords

neurology, synapse, Myasthenia gravis, neuromuscular disease, Electrophysiology

Opportunity ID

The opportunity ID for this research opportunity is: 2506

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