Imaging atherogenesis in a zebrafish model

Summary

This project will characterise immune cell dynamics during atherogenesis by live imaging, and investigate the importance of vascular remodelling and leakage in fuelling atheroma pathology.

Supervisor(s)

Dr Stefan Oehlers, Professor Warwick J Britton

Research Location

Camperdown - Centenary Institute

Program Type

Masters/PHD

Synopsis

Atherosclerosis and complications from atherosclerotic plaques are a leading cause of death and disability in Australia. The paradigm of foamy macrophages and lipid accumulation in the walls of blood vessels is well known. However, our understanding of the basic cellular dynamics that take place in atherogenesis has been limited by our ability to image the vessels in which these processes take place with appropriate resolution.
The zebrafish model of atherosclerosis is a visually accessible model of an intact animal that forms spontaneous atheromas. Using live imaging and experimental tools that have transformed our understanding of the tuberculosis granuloma, this project will study the immune cell interactions that occur during early atherosclerosis and test interventions to prevent atherogenesis.

Additional Information

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Keywords

inflammation, Immunology, Cardiovascular diseases, Vascular biology, Cell biology, Infection and immunity, tuberculosis

Opportunity ID

The opportunity ID for this research opportunity is: 2522

Other opportunities with Dr Stefan Oehlers

Other opportunities with Professor Warwick J Britton