Bio-functional Porous Materials as Efficient Platforms for Stem Cell Expansion

Summary

A PhD project in the area of Stem Cell Biotechnology is available in the Charles Perkins Centre at the University of Sydney. The successful applicant will join a multi-disciplinary international research team focused on the development of high surface-area-to-volume functional materials for biomedical applications. 
A complimentary scholarship for this project is available. To find out more, refer to the Postgraduate Research Scholarship in Biotechnology.

Supervisor(s)

Dr Giselle Yeo, Professor Marcela Bilek

Research Location

School of Life and Environmental Sciences

Program Type

PHD

Synopsis

Regenerative stem cells are increasingly being used as new therapeutics in the clinic, but current technologies to expand these cells and to direct their behaviour are still very limited. In this project, you will develop biofunctionalized porous materials for stem cell culture and manipulation. You will evaluate the viability, spatial distribution, proliferation, and differentiation of human bone marrow-derived mesenchymal stem cells within these materials. You will also explore the effects of spatially-structured biomolecules on stem cell responses. You will learn a broad range of stem cell culture and characterisation techniques, including cell assays, histochemical analyses, confocal imaging, and flow cytometry. This project will be conducted at the Charles Perkins Centre in collaboration with the Applied Plasma and Surface Engineering group at the University of Sydney.

Additional Information

A complimentary scholarship for this project is available. To find out more, refer to the Postgraduate Research Scholarship in Biotechnology.
HDR Inherent Requirements

In addition to the academic requirements set out in the Science Postgraduate Handbook, you may be required to satisfy a number of inherent requirements to complete this degree. Example of inherent requirement may include:

- Confidential disclosure and registration of a disability that may hinder your performance in your degree;
- Confidential disclosure of a pre-existing or current medical condition that may hinder your performance in your degree (e.g. heart disease, pace-maker, significant immune suppression, diabetes, vertigo, etc.);
- Ability to perform independently and/or with minimal supervision;
- Ability to undertake certain physical tasks (e.g. heavy lifting);
- Ability to undertake observatory, sensory and communication tasks;
- Ability to spend time at remote sites (e.g. One Tree Island, Narrabri and Camden);
- Ability to work in confined spaces or at heights;
- Ability to operate heavy machinery (e.g. farming equipment);
- Hold or acquire an Australian driver’s licence;
- Hold a current scuba diving license;
- Hold a current Working with Children Check;
- Meet initial and ongoing immunisation requirements (e.g. Q-Fever, Vaccinia virus, Hepatitis, etc.)

You must consult with your nominated supervisor regarding any identified inherent requirements before completing your application.

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Keywords

stem cell, Biotechnology, Materials Engineering, surface modification

Opportunity ID

The opportunity ID for this research opportunity is: 2538

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