Nanosensors and separators of enantimeric drug molecules

Summary

Bulk production and purity control of chiral drugs are severley limited by the complexity and laboriousness of current sensing and resolution techniques.  It is possible to overcome these limitations usuing mechanical and optical effects produced by chiral light on chrial molecules and chiral inorganic nanoparticles to develop essentially new concepts of sensing and purification of drug enantiomers.  This multidisciplinary project aims at exploiting the recently discovered giant optical activity of chiral inorganic nanoparticles to simplify the analysis of chiral synthetic drugs and unify enantioseperation methods, which can potentially transform the pharmaceutical industry with regard to drug recognition and racemate resolution.

Supervisor(s)

Dr Ivan Rukhlenko

Research Location

School of Physics

Program Type

PHD

Synopsis

Recently discovered giant optical activity of chiral inorganic nanostructures offers new opportunities for applications beyond the traditional field of molecular systems.  These include chiral molecular sensing, seperation and synthesis of enantiomers, super-resolution imaging, nanorobotics, and ultrathin broadband optical components for chiral light.  This multidisciplinary project aims to employ the fundamental physical advantages of chiral inorganic nanostructures to develop novel concepts of sensing and seperation of chirality on the nanoscale.  The theory will be supported by experimental demonstrations of luminescent sensors of enantiomeric molecules enabling fast quantification of minor impurities in chiral drugs.

Additional Information

Additional supervisors:  Dr Anvar Baimuratov, LMU Munich, Germany

HDR Inherent Requirements

In addition to the academic requirements set out in the Science Postgraduate Handbook, you may be required to satisfy a number of inherent requirements to complete this degree. Example of inherent requirement may include:

- Confidential disclosure and registration of a disability that may hinder your performance in your degree;
- Confidential disclosure of a pre-existing or current medical condition that may hinder your performance in your degree (e.g. heart disease, pace-maker, significant immune suppression, diabetes, vertigo, etc.);
- Ability to perform independently and/or with minimal supervision;
- Ability to undertake certain physical tasks (e.g. heavy lifting);
- Ability to undertake observatory, sensory and communication tasks;
- Ability to spend time at remote sites (e.g. One Tree Island, Narrabri and Camden);
- Ability to work in confined spaces or at heights;
- Ability to operate heavy machinery (e.g. farming equipment);
- Hold or acquire an Australian driver’s licence;
- Hold a current scuba diving license;
- Hold a current Working with Children Check;
- Meet initial and ongoing immunisation requirements (e.g. Q-Fever, Vaccinia virus, Hepatitis, etc.)

You must consult with your nominated supervisor regarding any identified inherent requirements before completing your application.

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Keywords

Chiral semiconductor nanocrystals, optical activity, enantiomorphism, Sensing, enantioseparation

Opportunity ID

The opportunity ID for this research opportunity is: 2639

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