Prostate cancer metabolism – investigating the role of lipid metabolism and the microenvironment

Summary

This project aims to investigate potential interaction the different cell types near the prostate gland and how changes in androgen signalling alters this relationship. It also aims to investigate the intra-prostate cancer metabolism and the role that lipid metabolism pathways play. The lab is located in the Charles Perkins Centre providing the opportunity to perform this project in a state of the art research environment.

Supervisor(s)

Dr Andrew Hoy

Research Location

Camperdown - School of Medical Sciences - Bosch Institute

Program Type

Masters/PHD

Synopsis

There is growing evidence of a potential role for metabolic processes regulating and/or sustaining cancer cell growth. This is evident as cancer cells are characterised by a dramatic change in their metabolic profile. Metabolic diseases such as obesity and type diabetes are also characterised by changes in metabolic processes but also changes in inter-tissue signals where the profile of cytokines and hormones released from organs that signal to other organs is deleterious in nature.Along these lines this project will investigate the relationship between adipocytes and prostate cancer. The project will involve cell culture (including primary and immortalised lines), human tumour explants and animal models with outputs including assessment of cellular metabolism by a variety of biochemical and radiometric techniques, and metabolomics/lipidomics approaches.

Additional Information

The lab is located in the Charles Perkins Centre providing the opportunity to perform this project in a state of the art research environment

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Keywords

Cancer, Lipid, Adipose, Prostate Cancer, metabolism

Opportunity ID

The opportunity ID for this research opportunity is: 435

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