Molecular dynamics simulations of ion channels and transporters

Summary

Understanding the function of ion channels and transporters using molecular dynamics simulations

Supervisor(s)

Associate Professor Serdar Kuyucak

Research Location

School of Physics

Program Type

Masters/PHD

Synopsis

Ion channels and transporters are formed by proteins in cell membranes.  They play key roles in creation and propagation of action potentials in nerves and muscles, which form the basis of all movement, sensation and thought processes.  Recent determination of the crystal structure of several channel and transporter proteins has enabled construction of models that can relate their function to the underlying molecular structure—necessary for understanding their operation and seeking cures for diseases caused by their dysfunction.  This project aims to develop molecular-level description of the function of channels or transporters using stochastic and molecular dynamics simulation methods.  After understanding their normal operation, effect of genetic mutations will be investigated, and therapeutic interventions that may ameliorate the operation of dysfunctional proteins will be sought.

Additional Information

HDR Inherent Requirements

In addition to the academic requirements set out in the Science Postgraduate Handbook, you may be required to satisfy a number of inherent requirements to complete this degree. Example of inherent requirement may include:

- Confidential disclosure and registration of a disability that may hinder your performance in your degree;
- Confidential disclosure of a pre-existing or current medical condition that may hinder your performance in your degree (e.g. heart disease, pace-maker, significant immune suppression, diabetes, vertigo, etc.);
- Ability to perform independently and/or with minimal supervision;
- Ability to undertake certain physical tasks (e.g. heavy lifting);
- Ability to undertake observatory, sensory and communication tasks;
- Ability to spend time at remote sites (e.g. One Tree Island, Narrabri and Camden);
- Ability to work in confined spaces or at heights;
- Ability to operate heavy machinery (e.g. farming equipment);
- Hold or acquire an Australian driver’s licence;
- Hold a current scuba diving license;
- Hold a current Working with Children Check;
- Meet initial and ongoing immunisation requirements (e.g. Q-Fever, Vaccinia virus, Hepatitis, etc.)

You must consult with your nominated supervisor regarding any identified inherent requirements before completing your application.

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Keywords

physics, Biophysics, computational biology, molecular dynamics, ion channels, transporters

Opportunity ID

The opportunity ID for this research opportunity is: 907

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