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Understanding the role of novel genes in disease

From mRNA arrays we have identified a number of ‘novel’ genes that influence tissue function. Our studies are investigating the biochemical basis for the mechanism of ac more...

Supervisor(s): Gamble, Jennifer (Professor)

Unravelling mechanisms determining the balance between tolerance and immunity in the liver

Role of primary T cell activation in the liver in CD8 T cell tolerance more...

Supervisor(s): Bertolino, Patrick (Dr)

Gene therapy for genetic and acquired diseases of the liver and haematopoietic system.

We are working on developing new therapies for the treatment of genetic and acquired diseases of the liver and haematopoietic system. The Gene Therapy Research Unit has a diverse se more...

Supervisor(s): Alexander, Ian (Professor), Ginn, Samantha (Dr), Logan, Grant (Dr)

The Role of Extracellular Matrix Metalloprotease Inducer (EMMPRIN) in Liver Disease

The role of the hepatocyte in progressive liver injury. more...

Supervisor(s): Shackel, Nicholas (Dr)

LDL-cholesterol controls the role of integrins in cancer cell migration

This project explores the role of LDL-cholesterol in integrin trafficking and signalling, which is relevant for cancer cell migration. more...

Supervisor(s): Grewal , Thomas (Associate Professor)

Targeting Rab7 and TBC1D15 to overcome mitochondrial dysfunction in neurological diseases

Pharmacological manipulation of contacts between mitochondria and LE/Lys could provide opportunities to improve PD, CMT2B and NPC disease. Virtual screening of compound libraries wi more...

Supervisor(s): Grewal , Thomas (Associate Professor), Groundwater, Paul (Professor), Hibbs, David (Dai) (Professor)

Characterization of the biological role of ARL6IP5 in HCV-induced liver cancer

This project suits someone with the intention to work towards PhD or Master's degrees. more...

Supervisor(s): Qiao, Liang (Dr), George, Jacob (Professor)

Link between ATP supply and consumption in the maintenance of the shape of the red blood cell in normal and disease states

The link between the main energy supply (ATP from glycolysis) and its consumption by the cytoskeleton will be studied by using nuclear magnetic resonance (NMR) spectroscopy, compute more...

Supervisor(s): Kuchel, Philip (Emeritus Professor)