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Novel therapy to prevent and treat kidney fibrosis

Progressive kidney disease is a global health burden most commonly caused by diabetes and obesity, which are dramatically on the rise. In Australia, 1 in 3 adults are at risk of dev more...

Supervisor(s): Saad, Sonia (Dr), Pollock, Carol (Professor)

Predicting the future risk of chronic kidney disease in offspring of obese mothers with and without type 2 diabetes

Chronic kidney disease (CKD) is a major health burden driven mostly by obesity and type 2 diabetes mellitus. 1/3 of diabetic patients are at risk of CKD progression for unknown reas more...

Supervisor(s): Saad, Sonia (Dr), Pollock, Carol (Professor)

Function and regulation of P-type ATPase ion pumps

The project aims to understand at the atomic level how the Na+,K+-ATPase and related ion pumps function and how they are regulated. more...

Supervisor(s): Clarke, Ron (Associate Professor)

The role of key driver genes in the pathogenesis of acute renal allograft rejection

This is a PhD project. The successful applicant will be top up scholarship. This study will lead to publish high quality of papers and apply a new NHMRC project grant. more...

Supervisor(s): O'Connell, Philip (Professor), Hu, Min (Dr)

Mitochondial DNA damage, potential target to reduce the development of renal disorders induced by maternal smoking .

Smoking rates are disproportionately high in disadvantaged populations, particularly in emerging economies, and increasing in women of child bearing age. more...

Supervisor(s): Saad, Sonia (Dr)

Mechanism of the effect of diabetes on the inflammation and subsequent fibrosis

In our laboratory we are investigating the effects of diabetes on the inflammatory response and the initiation of fibrosis and the relationship between these changes and the develop more...

Supervisor(s): McLennan, Susan (Dr)

Studies of a novel cancer gene with links to transcription

This project will investigate how a tumour suppressor implicated in a number of different malignancies functions to cause cancer. more...

Supervisor(s): Marsh, Deborah (Associate Professor)

Structure-based drug design with Soluble Epoxide Hydrolase

Soluble Epoxide Hydrolase (sEH), and more importantly its inhibition, may form the basis of a number of therapies due to anti-inflammatory more...

Supervisor(s): Church, W Bret (Dr)

Interactions between porcine ligands and the human lymphocyte activating receptor NKG2D

Role of NKG2D in the human cellular immune response against porcine xenotransplants. more...

Supervisor(s): Sharland, Alexandra (Dr)