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The role of a novel mutant gene in dementia and motor neuron disease

We have identified a new gene that when mutated causes dementia and motor neuron disease (MND), diseases that are currently incurable. This project will examine how this mutated gen more...

Supervisor(s): Dobson-Stone, Carol (Dr)

Investigating novel molecular mechanisms in motor neuron disease.

This project will use molecular and cell biology approaches to investigate known and novel motor neuron disease genes and the functional consequences of disease causing mutations. more...

Supervisor(s): Nicholson, Garth (Professor)

Muscle specific kinase in synaptic adaptation

This project will investigate the role of postsynaptic Muscle specific Kinase (MuSK) in regulating presynaptic neurotransmitter release at the neuromuscular junction. more...

Supervisor(s): Phillips, William (Bill) (Associate Professor), Protti, Dario (Dr)

Molecular Dynamics of Glutamate Transporters

The aim of this project is to develop a molecular model for the mechanism of glutamate transport and through this we expect to identify novel means of pharmacologically manipulating more...

Supervisor(s): Ryan, Renae (Associate Professor)

Cannabinoid regulation of neuromuscular transmission

Cannabinoid drugs are under active consideration for treatment of a wide range of health conditions. This electrophysiology project will investigate the influence of specific endoca more...

Supervisor(s): Phillips, William (Bill) (Associate Professor), Protti, Dario (Dr)

Determining the functional significance of non-coding DNA variants in genes for complex traits involving gene-environmental interactions

To identify non-protein coding DNA changes in genes that interact with the environment using 2 models – sporadic amyotrophic lateral sclerosis for the vulnerability to environ more...

Supervisor(s): Yu, Bing (Associate Professor)