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Chronic pain & endogenous cannabinoids.

Endogenous cannabinoids represent a potential therapeutic target for intractable pain states, this project will focus on how these agents produce their actions at the cellular level more...

Supervisor(s): Vaughan, Christopher (Dr)

Refining cell-based therapies to cure diabetes

The most promising route for a cure for type 1 diabetes is the use of insulin-secreting cells to replace those that have died. more...

Supervisor(s): Thorn, Peter (Professor)

Discovery and Development of Allosteric Modulators of Glycine Transporters and Glycine Receptors for the Treatment of Chronic Pain

We offer a variety projects around the discovery and development of new allosteric modulators of glycine transporters and receptors for the treatment of chronic pain. We use a compr more...

Supervisor(s): Vandenberg, Robert (Professor)

Computational investigation of high affinity ligand binding to proteins

Design of high-affinity ligands for protein targets using docking, molecular dynamics simulations and quantitative structure-activity relations. more...

Supervisor(s): Kuyucak, Serdar (Associate Professor)

Phosphoproteomics in early T-cell signalling

Using phospho-proteomics to understand T-cell signalling/signal transduction. more...

Supervisor(s): Manolios, Nicholas (Professor)

A Novel Approach of Inhibiting Pancreatic Cancer Metastasis via Targeting Tumour Micro-Environment Induced Autophagy

Targeting autophagy and metastasis in pancreatic cancer via NDRG1 Pancreatic Cancer (PC) is highly metastatic with the highest mortality of all cancers (~93%). The pancreatic tu more...

Supervisor(s): Sahni, Sumit (Dr)

Mechanisms of T cell migration and interactions in the tumor microenvironment

The project will use intravital two-photon microscopy to determine the molecules involved in interstitial T cell migration and the molecular mechanisms of T cell interactions with t more...

Supervisor(s): Weninger , Wolfgang (Professor)

Biology of Dipeptidyl Peptidase IV and related proteins

Research projects centre on mouse models of liver disease and obesity and on the delineation of inhibitors, substrates, biochemistry and in vivo expression and function of the Dipep more...

Supervisor(s): Gorrell, Mark (Associate Professor)

Proteomic Mapping and Molecular Modelling of Avian H5N1 Influenza Antigen Epitopes Targeted by Human Antibodies

In studying Avian H5N1 Influenza specific Antibodies within Humans the aim is to clearly and definitively identify the respective viral proteins and epitopes targeted by neutralizin more...

Supervisor(s): Lynch, Garry (Dr)

Interactions between porcine ligands and the human lymphocyte activating receptor NKG2D

Role of NKG2D in the human cellular immune response against porcine xenotransplants. more...

Supervisor(s): Sharland, Alexandra (Dr)