About Associate Professor Brett Hambly

My research goal is to understand the biochemical and molecular mechanisms underlying muscle contraction, and how defects at the molecular level can lead to muscle diseases such as cardiomyopathy and atherosclerosis.

My research focuses on cardiovascular disease, in particular familial hypertrophic cardiomyopathy and atherosclerosis.

Significant Contributions: Dr Hambly has over 20 years experience in cardiovascular disease research, encomp-assing basic muscle biochemistry through to the pathology of cardiovascular disease. He was the first to dem-onstrate experimentally that the myosin head generates force by “bending” near its centre [Biophys. J. (1991) 59:127], work which continues to today [Biophys. J. (2004) 86:3030]. He was involved in the discovery of the most common cause of Familial Hypertrophic Cardio-myopathy - mutations in the cardiac regulatory protein, myosin binding protein C [J. Med. Genet. (1998) 35:205] and biophysical studies of this protein remain a focus [eg Int J Biochem Cell Biol (2007) in press]. In the area of I/R injury, in collaboration with SI Cordwell, he has gener-ated novel data that has shifted the paradigm for the aetiology of injury away from the concept of a single cause, to our current understanding that I/R is a consequence of damage to multiple proteins. Awards and Honours: Dr Hambly is the program leader for Cardiovascular Research in the Bosch Institute at the University of Sydney. He is also an Honorary Adjunct Professor of Biology (Molecular Biophysics) at the Florida State University, Tallahassee, U.S.A. He has supervised 15 PhD students and 30 Honours students. He has won several awards for his research from the NHF (2002 and 2004). Invited and Plenary Presentations: Recognition of the international standing of Dr Hambly's research is provided by several recent invitations to speak at national and international conferences and seminars, including the annual meetings of the Australian Society for Biophysics, the Chinese Academy of Sciences, Shanghai (2002), the Australian Electrophoresis and Proteomics Society (2002), the Centenary Research Institute, Sydney (2002), Children’s Medical Research Institute, Sydney (2002), Florida State University (2003), and the American Heart Association (2004-2006). Scientific Community: Dr Hambly is currently the President of the Australian Society for Biophysics. Other: Guest Editor, Electrophoresis (2000), regularly reviews manuscripts for Electrophoresis, Eur J Biochem, J Biomolec NMR, Biochemistry (USA), Cell Research, as well as providing peer review for grants submitted to the Wellcome Trust, NHMRC, ARC, and NHF.

Selected publications

For a comprehensive list of Associate Professor Hambly's publicatons, please visit his Sydney Medical School profile page.