About Dr Milena Simic

Dr Simic is passionate about developing novel methods of preventing and treating knee osteoarthritis. This includes research involving exercise, biomechanics, e-health, and behaviour change.

Dr Simic is a senior lecturer in Physiotherapy and Director of the Sydney Performance Laboratory. She has expertise in the conduct of cohort studies, biomechanical evaluations, intervention studies, clinical trials, systematic reviews and meta-analyses for musculoskeletal conditions. Currently, she is investigating medication use in people with knee osteoarthritis, and developing interventions aimed at reducing their harmful use. She works on physiotherapy interventions involving exercise, physical activity, cognitive behavioural therapy, and delivery through e-health platforms. In the biomechanics field, she is working on the development of clinical evaluations, gait retraining strategies to offload the knee joint, and validation of wearable sensors.

Dr Simic has attracted over $1.9 million of funding from agencies including:  NHMRC, Medibank Health Research Fund, Dementia Collaborative Research Centres and The University of Sydney.  She is a CIB on a recently funded NHMRC project (A$1.5M) which will translate evidence and knowledge in management of top three musculoskeletal health conditions, of which she leads the knee osteoarthritis management.  She is currently working on multiple large randomised controlled trials evaluating non-invasive interventions for people with musculoskeletal disorders.

Selected publications

  1. Simic, M., Hinman, R. S., Wrigley, T. V., Bennell, K. L., & Hunt, M. A. (2011). Gait modification strategies for altering medial knee joint load: A systematic review. Arthritis Care & Research, 63(3), 405-426.
  2. Palad, Y. Y., Leaver, A. M., McKay, M. J., Baldwin, J. N., Lunar, F. R. M., Caube, F. D. M., ...Simic, M. (2018). Knee thrust prevalence and normative hip-knee-ankle angle deviation values among healthy individuals across the lifespan. Osteoarthritis and Cartilage, 26(10), 1326-1332.
  3. Fransen, M., McConnell, S., Harmer, A. R., Van der Esch, M., Simic, M., & Bennell, K. L. (2015). Exercise for osteoarthritis of the knee. Cochrane Database of Systematic Reviews(1), Art. No.: CD004376.
  4. Kobayashi, S., Pappas, E., Fransen, M., Refshauge, K., & Simic, M. (2016). The prevalence of patellofemoral osteoarthritis: a systematic review and meta-analysis. Osteoarthritis and Cartilage, 24(10), 1697-1707.
  5. Simic, M., Wrigley, T. V., Hinman, R. S., Hunt, M. A., & Bennell, K. L. (2013). Altering foot progression angle in people with medial knee osteoarthritis: the effects of varying toe-in and toe-out angles are mediated by pain and malalignment. Osteoarthritis and Cartilage, 21(9), 1272-1280.
  6. Simic, M., Hunt, M. A., Bennell, K. L., Hinman, R. S., & Wrigley, T. V. (2012). Trunk lean gait modification and knee joint load in people with medial knee osteoarthritis: The effect of varying trunk lean angles. Arthritis Care & Research, 64(10), 1545-1553. doi:10.1002/acr.21724
  7. Simic, M., Bennell, K. L., Hunt, M. A., Wrigley, T. V., & Hinman, R. S. (2011). Contralateral cane use and knee joint load in people with medial knee osteoarthritis: The effect of varying body weight support. Osteoarthritis and Cartilage, 19(11), 1330-1337. doi:10.1016/j.joca.2011.08.008
  8. Amorim, A. B., Pappas, E., Simic, M., Ferreira, M. L., Tiedemann, A., Jennings, M., & Ferreira, P. H. (2016). Integrating Mobile health and Physical Activity to reduce the burden of Chronic low back pain Trial (IMPACT): a pilot trial protocol. Bmc Musculoskeletal Disorders, 17(1), 1-8.
  9. Ismail, S. A., Simic, M., Salmon, L. J., Roe, J. P., Pinczewski, L. A., Smith, R., & Pappas, E. (2018). Side-to-Side Differences in Varus Thrust and Knee Abduction Moment in High-Functioning Individuals With Chronic Anterior Cruciate Ligament Deficiency. The American Journal of Sports Medicine, doi: 10.1177/0363546518812883.
  10. McKay, M. J., Baldwin, J. N., Ferreira, P., Simic, M., Vanicek, N., Burns, J., & Consortium, F. t. N. P. (2017). Normative reference values for strength and flexibility of 1,000 children and adults. Neurology, 88(1), 36-43.