About Dr Lifeng Kang

Drug delivery and tissue engineering

Dr. Kang develops precision medicine by using engineering tools including microscale technology and three-dimensional printing. He works closely with clinicians to find the unmet needs from patients. He also works with biologists to understand the mechanisms underlying each disease. For example, he fabricates curved microneedle patches conforming with body contour to deliver therapeutics through skin non-invasively. By utilizing 3D printing technology and biomaterials, he builds testing systems for drug delivery via skin and lung to enable patient-specific evaluation of drug candidates. For tissue engineering, he fabricated microgel systems to create human cardiac microtissues to treat heart disease. In addition, he also works on stem cells for hair follicle regeneration

Lifeng Kang is a Lecturer at the University of Sydney, School of Pharmacy. His laboratory is focused on microscale technologies for drug delivery and tissue engineering. In drug delivery, drug carriers can be precisely designed and fabricated with built-in micro-scale features to facilitate the controlled release of drugs into human tissue. In tissue engineering, micro-scale technologies are used to fabricate scaffolds with increased complexity to control the cellular microenvironment and enhance cell-cell, cell-matrix and cell-soluble factor interactions. Dr. Kang has published 2 books, 53 peer-reviewed papers (44 as the main author), 74 abstracts and filed 8 patent applications (2 granted). His work has been published in leading journals such as Advanced Drug Delivery Review, Journal of Controlled release, Molecular Pharmaceutics, Advanced Functional Materials, Biofabrication, Journal of Materials Chemistry.
He is highly interested in innovation. One of his patents on miniaturized skin permeation testing device has been licensed to a local start-up company. The company is now actively raising funds to commercialize the device for cosmeceutical compound skin permeation testing.

He is committed in training students. In his laboratory, he has supervised 8 postgraduate students. He teaches both undergraduate and postgraduate courses. He is also investigating the formative assessment and mastery learning in university educations.Dr. Kang obtained his Ph.D. from the National University of Singapore in 2006 on drug delivery. Afterwards he went to the Massachusetts Institute of Technology to study tissue engineering by using microfabricated hydro-gels. He returned to the National University of Singapore in 2009 to work as a lecturer. In the summer of 2017, He joined University of Sydney, School of Pharmacy as a lecturer. He also studied hydro-gel as drug carriers for his M.S. degree in China Pharmaceutical University where he completed his undergraduate education as well. More information can be found at his web site: kanglab.net

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Selected publications

1. Lim SH, Kathuria H, Tan JJY, Kang L. Nov 2018. 3D printed drug delivery and testing systems. Advanced Drug Delivery Reviews. 132: 139-168. DOI: 10.1016/j.addr.2018.05.006
2. Tan JJY, Tee JK, Chou KO, Yong SYA, Pan J, Ho HK, Ho PCL, Kang L. May 2018. Impact of substrate stiffness on dermal papilla aggregates in microgels. Biomaterials Science. 6(6):1347-1357. DOI: 10.1039/c8bm00248g. (Journal cover)
3. Lim SH, Ng JY, Kang L. Jan 2017. 3-dimensional printing of a microneedle array on personalized curved surface for dual prong treatment of trigger finger. Biofabrication. 9(1):015010. DOI: 10.1088/1758-5090/9/1/015010.
4. Li H, Bao H, Bok KX, Lee CY, Li B, Zin MT, Kang L. Jan 2016. High durability and low toxicity antimicrobial coatings fabricated by quaternary ammonium silane copolymers. Biomaterials Science. 4:299-309. DOI: 10.1039/C5BM00353A
5. Nguyen DV, Li F, Li H, Wong BS, Low CY, Liu XY, Kang L. Feb 2015. Drug permeation through skin is inversely correlated with carrier gel rigidity. Molecular Pharmaceutics. 12(2):444-452. DOI: 10.1021/mp500542a
6. Kochhar JS, Anbalagan P, Shelar SB, Neo JK, Iliescu C, Kang L. Jul 2014. Direct microneedle array fabrication off a photomask to deliver collagen through skin. Pharmaceutical Research. 31(7):1724-1734. DOI: 10.1007/s11095-013-1275-1. (Featured by Reuters, http://uk.reuters.com/video/2014/10/18/microneedle-patch-promises-painless-pric?videoId=346623719&videoChannel=4000).
7. Kochhar JS, Lim WX S, Zou S, Foo WY, Pan J, Kang L. Nov 2013. Microneedle integrated transdermal patch for fast onset and sustained delivery of lidocaine. Molecular Pharmaceutics. 10 (11): 4272-4280. DOI: 10.1021/mp400359w. (Featured by NUS Research Highlights, http://www.science.nus.edu.sg/research-highlights/979-microneedles-for-fast-onset-and-sustained-delivery-of-a-pain-killer)
8. Kang L, Chung B, Langer R, Khademhosseini A. Jan. 2008. Microfluidics for drug discovery and development: From target selection to product lifecycle management. Drug Discovery Today. 13:1-13. DOI: 10.1016/j.drudis.2007.10.003
9. Kang L, Yap CW, Lim PF, Chen YZ, Ho PC, Chan YW, Wong GP, Chan SY. Jul. 2007. Formulation development of transdermal dosage forms: Quantitative structure-activity relationship model for predicting activities of terpenes that enhance drug penetration through human skin. Journal of Controlled Release. 31(3):211-219. DOI: 10.1016/j.jconrel.2007.05.006
10. Kang L, Liu XY, Sawant PD, Ho PC, Chan YW, Chan SY. Aug. 2005. SMGA gels for the skin permeation of haloperidol. Journal of Controlled Release 106:89-98. DOI: 10.1016/j.jconrel.2005.04.017