About Dr Damian Holsinger

The drive behind my research activities is to understand mechanisms by which complex neurological disorders arise and methods of treating these diseases.

Dr Holsinger is an accomplished neuroscientist and was the first to demonstrate that a pivotal enzyme involved in Alzheimer's disease (AD), referred to as beta-secretase (BACE1), was increased in AD brain.

Damian Holsinger is a Lecturer in Neuroscience and Head of the Laboratory of Molecular Neuroscience at the Brain & Mind Research Institute at the University of Sydney. Damian graduated with a B.Sc. (Hons) in Neuroscience from the University of Toronto and a M.Sc. degree in Neurobiology from McMaster University in Canada. Following this he obtained a Ph.D. in Neuroscience from The University of Melbourne in Australia. After completing research studies investigating neurophysiological events underlying epilepsy at the University of Toronto Damian changed his field of research to molecular biology during his M.Sc. studies investigating mRNA and proteins levels of Brain Derived Neurotrophic Factor (BDNF) in Alzheimer’s disease subjects. Continuing the theme of molecular neuroscience, Damian commenced a Ph.D. investigating a recently identified enzyme that is known to contribute to the pathology associated with Alzheimer’s disease (AD). Damian was the first to demonstrate that protein levels of this enzyme, BACE1, were significantly elevated in AD brain, a finding that has now led to therapeutic attempts for treating this devastating form of dementia. Damian joined the University of Sydney in January 2006 and has established The Laboratory of Molecular Neuroscience and The Laboratory of Receptor Protein Biology at the Brain & Mind Research Institute where he actively pursues his research interests. He currently supervises five postgraduate students as well as an honours student. Damian currently serves as an Academic Board Nominee for the University of Sydney, a grant reviewer for the Alzheimer’s Association USA and a reviewer for the Human Protein Reference Database.

Selected publications

For a comprehensive list of Dr Holsinger's publicatons, please visit his Sydney Medical School profile page.