About Dr Thomas J Hugh

• Clinical outcomes following resection of Colorectal Liver Metastases. • Quality of Life after major liver surgery for malignant tumours. • Effect of regular surveillance investigations on Quality of Life after cancer surgery. • Markers of early tumour recurrence in patients with malignant hepato-biliary and pancreatic cancer

The Hepato-Biliary and Pancreatic Surgical Unit at Royal North Shore Hospital performs a large volume of complex hepato-biliary and pancreatic surgery mainly for malignant disease. There are two Consultant Surgeons working in this unit and both have a major interest in clinical and laboratory-based research. Within the unit, there is a large clinical database as well as a cancer tumour bank containing more than 300 samples of frozen resected tumour specimens. This serves as a platform for clinical and laboratory research regarding outcomes in patients with hepato-biliary and pancreatic cancer malignancy. Our unit has a full-time Data Manager to assist with statistical analysis and database design and maintenance as well as numerous administrative staff. Other areas of research interest include clinical outcomes following inguinal and incisional hernia surgery, particularly minimally invasive, day-only surgery. Our unit has a close affiliation with the Kolling Institute and, in conjunction with several research scientists, we undertake research into the molecular biology of hepato-biliary and pancreatic tumours.

Both clinically active HPB surgeons have higher degrees (cellular oncology and biochemistry).  The third senior member of the unit (Professor Ross Smith) also has a higher degree and has pursued a major interest in clinical and laboratory-based research throughout his career, specifically in the field of protein metabolism and nutrition.  More recently, our unit has been investigating the role of biomarkers in hepatobiliary and pancreatic cancer using proteonomics. Each year the unit publishes 3-4 papers in peer-reviewed journal.

Selected publications

For a comprehensive list of Dr Hugh's publicatons, please visit his Sydney Medical School profile page.