About Dr Mark Graham

Dr Mark Graham works at the interface of chemistry and biology, since many of the greatest breakthroughs in biology have been driven by improved molecular analysis. His work is guided by the principal that disease prevention will require a greater understanding of molecular mechanisms and cellular signalling pathways.

Dr Graham’s main interest is revealing cellular signalling mechanisms. Dr Graham uses both large-scale proteomics analysis and targeted functional studies to identify the molecular basis for normal brain function and to identify new therapeutic targets for neurological diseases.

Dr Graham has been working for over fifteen years in the field of neurochemistry. He has published over thirty-five research articles, many of which were in high impact journals, including Science, Nature Cell Biology and Nature Neuroscience. Using his expertise in phosphoproteomics and synaptic biology, he has revealed in extraordinary detail, the pathways and master regulators of neuronal activity in a recent article in PLOS Biology. This involved the optimisation of workflows for global phosphoproteomics and the development of tools for bioinformatics. This expertise is now being applied to models of synaptic plasticity, underlying learning and memory, and to epilepsy models.

Selected publications

For a comprehensive list of Dr Graham's publicatons, please visit his Sydney Medical School profile page.